Results 61 to 70 of about 34,648 (287)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

DNA barcoding as a complementary tool for conservation and valorisation of forest resources

ZooKeys, 2013
Since the pre-historic era, humans have been using forests as a food, drugs and handcraft reservoir. Today, the use of botanical raw material to produce pharmaceuticals, herbal remedies, teas, spirits, cosmetics, sweets, dietary supplements, special ...
Angeliki Laiou, Luca Aconiti Mandolini, Roberta Piredda, Rosanna Bellarosa, Marco Cosimo Simeone   +4 more
doaj   +1 more source

Evaluating the Utility of Single-Locus DNA Barcoding for the Identification of Ribbon Worms (Phylum Nemertea). [PDF]

PLoS ONE, 2016
Whereas many nemerteans (ribbon worms; phylum Nemertea) can be identified from external characters if observed alive, many are still problematic. When it comes to preserved specimens (as in e.g.
Per Sundberg, Sebastian Kvist, Malin Strand   +2 more
doaj   +1 more source

Finding needles in haystacks: linking scientific names, reference specimens and molecular data for Fungi [PDF]

, 2014
DNA phylogenetic comparisons have shown that morphology-based species recognition often underestimates fungal diversity. Therefore, the need for accurate DNA sequence data, tied to both correct taxonomic names and clearly annotated specimen data, has ...
Abarenkov, K, Aime, MC, Ariyawansa, HA, Bidartondo, M, Boekhout, T, Buyck, B, Cai, Q, Cardinali, G, Chen, J, Crespo, A, Crous, PW, Damm, U, De Beer, ZW, Dentinger, BTM, Dieguez Uribeondo, J, Divakar, PK, Duenas, M, Duong, V, Feau, N, Federhen, S, Fliegerova, K, Garcia, MA, Ge, Z-W, Griffith, G, Groenewald, JZ, Groenewald, M, Grube, M, Gryzenhout, M, Gueidan, C, Guo, L, Hambleton, S, Hamelin, R, Hansen, K, Hofstetter, V, Hong, S-B, Houbraken, J, Hughes, K, Hyde, KD, Inderbitzin, P, Irinyi, L, Johnston, PR, Karunarathna, SC, Kirk, PM, Koljalg, U, Kovacs, GM, Kraichak, E, Krizsan, K, Kurtzman, CP, Larsson, K-H, Leavitt, S, Letcher, PM, Liimatainen, K, Liu, J-K, Lodge, DJ, Luangsa-ard, JJ, Lumbsch, HT, Maharachchikumbura, SSN, Manamgoda, D, Martin, MP, Meyer, W, Miller, AN, Minnis, AM, Moncalvo, J-M, Mule, G, Nakasone, KK, Nilsson, RH, Niskanen, T, Olariaga, I, Papp, T, Petkovits, T, Pino-Bodas, R, Powell, MJ, Raja, HA, Redecker, D, Robbertse, B, Robert, V, Sarmiento-Ramirez, JM, Schoch, CL, Seifert, KA, Shrestha, B, Stenroos, S, Stielow, B, Subbarao, KV, Suh, S-O, Tanaka, K, Tedersoo, L, Teresa Telleria, M, Udayanga, D, Untereiner, WA, Vagvoelgyi, C, Visagie, C, Voigt, K, Walker, DM, Weir, BS, Weiss, M, Wijayawardene, NN, Wingfield, MJ, Xu, JP, Yang, ZL, Zhang, N, Zhuang, W-Y   +100 more
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Taxonomic rank of Indian tortoise: revisit with DNA barcoding perspective

DNA Barcodes, 2013
Taxonomic rank of terrestrial tortoise inhabiting in India and adjacent countries has been an unresolved issue. Wild living species of Manouria and Indotestudo genera have been classiied through conventional taxonomy, but not adequately discriminated by mitochondrial cytochrome b gene.
Shantanu Kundu, Kulendra Chandra Das, Sankar Kumar Ghosh   +2 more
openaire   +1 more source

Taxonomic, DNA Barcoding and Phylogenetic Reassessment of the Egyptian Ephedra L. (Ephedraceae) [PDF]

Catrina: The International Journal of Environmental Sciences, 2018
This study attempts to carry out a critical revision for the genus Ephedra in Egypt based on morpholo-gical characters for leaf, stem and flower. DNA sequencing data used for the first time for DNA barcoding of the family Ephedraceae in Egypt. One chloroplast marker-intergenic spacer trn-H/psb-A and another nuclear Internal Transcribed Spacer (ITS ...
Ahmed Faried, Ahmed EL-Banhawy, Mesfer Elqahtani   +2 more
openaire   +1 more source

Genomic islands of divergence in the Yellow Tang and the Brushtail Tang Surgeonfishes. [PDF]

, 2018
The current ease of obtaining thousands of molecular markers challenges the notion that full phylogenetic concordance, as proposed by phylogenetic species concepts, is a requirement for defining species delimitations.
Avise J. C., Bauchot M. L., De Queiroz K., Kuiter R. H., Ma T., Randall J. E., Randall J. E., Weir B. S., Wiley E. O.   +8 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

PROTAX-GPU: a scalable probabilistic taxonomic classification system for DNA barcodes

Philosophical Transactions of the Royal Society B: Biological Sciences
DNA-based identification is vital for classifying biological specimens, yet methods to quantify the uncertainty of sequence-based taxonomic assignments are scarce. Challenges arise from noisy reference databases, including mislabelled entries and missing taxa.
Roy Li, Sujeevan Ratnasingham, Iuliia Zarubiieva, Panu Somervuo, Graham W. Taylor   +4 more
openaire   +3 more sources