Results 61 to 70 of about 66,386 (283)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

DNA barcoding of commercially important reef fishes in Weh Island, Aceh, Indonesia

PeerJ, 2020
Knowledge on the precise identification of fish resources is critical for sustainable fisheries management. This study employs the DNA barcoding approach to generate a molecular taxonomic catalogue of commercially important reef fishes in the waters of ...
N. Fadli, Siti Azizah Mohd Nor, A. S. Othman, H. Sofyan, Z. Muchlisin   +4 more
semanticscholar   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

DNA barcoding deep-water zooplankton from the Gulf of Alaska, North Pacific Ocean

Frontiers in Marine Science
DNA barcoding is a method of identifying individual organisms using short DNA fragments matched to a database of reference sequences. For metazoan plankton, a high proportion of species that reside in the deep ocean still lack reliable reference ...
Jennifer M. Questel, Caitlin A. Smoot, Allen G. Collins, Allen G. Collins, Dhugal J. Lindsay, Russell R. Hopcroft   +5 more
doaj   +1 more source

Identification of Amazonian trees with DNA barcodes. [PDF]

PLoS ONE, 2009
BACKGROUND:Large-scale plant diversity inventories are critical to develop informed conservation strategies. However, the workload required for classic taxonomic surveys remains high and is particularly problematic for megadiverse tropical forests ...
Mailyn Adriana Gonzalez, Christopher Baraloto, Julien Engel, Scott A Mori, Pascal Pétronelli, Bernard Riéra, Aurélien Roger, Christophe Thébaud, Jérôme Chave   +8 more
doaj   +1 more source

A DNA Barcoding Survey of an Arctic Arthropod Community: Implications for Future Monitoring

Insects, 2020
Accurate and cost-effective methods for tracking changes in arthropod communities are needed to develop integrative environmental monitoring programs in the Arctic.
Mikko Pentinsaari, G. Blagoev, I. Hogg, V. Levesque-Beaudin, K. Perez, Crystal N. Sobel, Bryan Vandenbrink, A. Borisenko   +7 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Highlighting Astyanax Species Diversity through DNA Barcoding. [PDF]

PLoS ONE, 2016
DNA barcoding has been used extensively to solve taxonomic questions and identify new species. Neotropical fishes are found in a wide variety of shapes and sizes, with a large number of species yet to be described, many of which are very difficult to ...
Bruno César Rossini, Carlos Alexandre Miranda Oliveira, Filipe Augusto Gonçalves de Melo, Vinicius de Araújo Bertaco, Juan M Díaz de Astarloa, Juan J Rosso, Fausto Foresti, Claudio Oliveira   +7 more
doaj   +1 more source

Mitochondrial plastid DNA can cause DNA barcoding paradox in plants

Scientific Reports, 2020
The transfer of ancestral plastid genomes into mitochondrial genomes to generate mitochondrial plastid DNA (MTPT) is known to occur in plants, but its impacts on mitochondrial genome complexity and the potential for causing a false-positive DNA barcoding
Hyun-Seung Park, Murukarthick Jayakodi, S. Lee, Jae-Hyeon Jeon, Hyun-Oh Lee, J. Park, B. Moon, Chang-Kug Kim, R. Wing, S. Newmaster, J. Y. Kim, Tae-Jin Yang   +11 more
semanticscholar   +1 more source