Results 11 to 20 of about 353,576 (232)

Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer. [PDF]

PLoS ONE, 2012
BACKGROUND: Genomic instability with frequent DNA copy number alterations is one of the key hallmarks of carcinogenesis. The chromosomal regions with frequent DNA copy number gain and loss in human gastric cancer are still poorly defined.
Biao Fan, Somkid Dachrut, Ho Coral, Siu Tsan Yuen, Kent Man Chu, Simon Law, Lianhai Zhang, Jiafu Ji, Suet Yi Leung, Xin Chen   +9 more
doaj   +8 more sources

Reconstructing DNA copy number by joint segmentation of multiple sequences [PDF]

BMC Bioinformatics, 2012
Background Variations in DNA copy number carry information on the modalities of genome evolution and mis-regulation of DNA replication in cancer cells. Their study can help localize tumor suppressor genes, distinguish different populations of cancerous ...
Zhang Zhongyang, Lange Kenneth, Sabatti Chiara   +2 more
doaj   +6 more sources

Accuracy of expanded noninvasive prenatal testing for maternal copy number variations: A comparative study with CNV-seq of maternal lymphocyte DNA

Taiwanese Journal of Obstetrics & Gynecology
Objective: To evaluate the accuracy of expanded noninvasive prenatal testing (NIPT) for maternal copy number variations. Materials and methods: Expanded NIPT was used to detect CNVs ≥2 Mb at a whole-genome scale.
Honglei Duan, Wanjun Wang, Ying Zhang, Xuemei Chen, Zihan Jiang, Jie Li   +5 more
doaj   +2 more sources

Association of Mitochondrial DNA Copy Number Variations with Triple-Negative Breast Cancer: A Potential Biomarker Study [PDF]

Diseases
Background/Objectives: Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited therapeutic options, and identifying reliable biomarkers for diagnosis and prognosis is crucial for improving patient outcomes.
Karin Manto, Sevdican Ustun Yilmaz, Zeliha Pala Kara, Halil Kara, Fatma Tokat, Cemaliye B. Akyerli, Cihan Uras, Meltem Muftuoglu, Ugur Özbek   +8 more
doaj   +2 more sources

Copy number variation at leptin receptor gene locus associated with metabolic traits and the risk of type 2 diabetes mellitus [PDF]

BMC Genomics, 2010
Background Recent efforts have been made to link complex human traits and disease susceptibility to DNA copy numbers. The leptin receptor (LEPR) has been implicated in obesity and diabetes.
Kim Hyung-Lae, Hong Eun-Jung, Ryu Gil-Mi, Nam Hye-Young, Shim Sung-Mi, Jeon Jae-Pil, Han Bok-Ghee   +6 more
doaj   +4 more sources

DNA copy number, including telomeres and mitochondria, assayed using next-generation sequencing

BMC Genomics, 2010
Background DNA copy number variations occur within populations and aberrations can cause disease. We sought to develop an improved lab-automatable, cost-efficient, accurate platform to profile DNA copy number.
Jackson Stuart, Misura Kira, Chen Ronghua, Xie Tao, Bouzek Heather, Biery Matthew, Castle John C, Armour Christopher D, Johnson Jason M, Rohl Carol A, Raymond Christopher K   +10 more
doaj   +2 more sources

Cell-Free DNA From Metastatic Pancreatic Neuroendocrine Tumor Patients Contains Tumor-Specific Mutations and Copy Number Variations

Frontiers in Oncology, 2018
Background: Detection of tumor-specific alterations in cell-free DNA (cfDNA) has proven valuable as a liquid biopsy for several types of cancer. So far, use of cfDNA remains unexplored for pancreatic neuroendocrine tumor (PNET) patients.Methods: From 10 ...
Gitta Boons, Gitta Boons, Timon Vandamme, Timon Vandamme, Timon Vandamme, Timon Vandamme, Marc Peeters, Marc Peeters, Matthias Beyens, Matthias Beyens, Ann Driessen, Katrien Janssens, Karen Zwaenepoel, Geert Roeyen, Guy Van Camp, Ken Op de Beeck, Ken Op de Beeck   +16 more
doaj   +2 more sources

Advances of nanopore direct sequencing technology and bioinformatics analysis for cell-free DNA detection and its clinical applications in cancer liquid biopsy [PDF]

Frontiers in Molecular Biosciences
Cell-free DNA (cfDNA) containing cancer information has become a key biomarker for cancer liquid biopsy. Current next-generation sequencing (NGS) technology for cfDNA detection often fail to capture multiomics information, such as fragmentomics ...
Jiaxin Tan, Jiaxin Tan, Zetong Wu, Yunya Zhu, Biyuan Miao, Biyuan Miao, Daofeng Xu, Jia Gu, Maohong Hu, Pingping Xu, Shaogui Wan   +10 more
doaj   +2 more sources

mtDNA copy number/miR663/AATF axis in invasive ductal carcinoma of the breast [PDF]

BioImpacts
Introduction: Mitochondrial DNA (mtDNA) copy number variations have been reported in multiple human cancers. Previous studies indicate that mitochondrial retrograde signaling regulates miR663, which plays a key role in tumorigenesis, including regulating
Farzaneh Dahi, Shirin Shahbazi, Loabat Geranpayeh   +2 more
doaj   +2 more sources

DNA copy number variations characterize benign and malignant thyroid tumors.

J Clin Endocrinol Metab, 2013
Liu Y, Cope L, Sun W, Wang Y, Prasad N, Sangenario L, Talbot K, Somervell H, Westra W, Bishop J, Califano J, Zeiger M, Umbricht C.   +12 more
europepmc   +2 more sources