Results 141 to 150 of about 5,698,803 (355)

The concerted roles of FANCM and Rad52 in the protection of common fragile sites

Nature Communications, 2018
Fanconi anemia core proteins have been linked to common fragile site stability. Here the authors shed light into the role of FANCM in common fragile site protection by suppressing double-strand break formation and mitotic recombination.
Hailong Wang, Shibo Li, Joshua Oaks, Jianping Ren, Lei Li, Xiaohua Wu   +5 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands [PDF]

, 2011
Heather M. O’Hagan, Wei Wang, Subhojit Sen, Christina E. DeStefano Shields, Stella S. Lee, Yang W. Zhang, Eriko G. Clements, Yi Cai, Leander Van Neste, Hariharan Easwaran, Robert A. Casero, Cynthia L. Sears, Stephen B. Baylin   +12 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Rad51 replication fork recruitment is required for DNA damage tolerance [PDF]

, 2013
Román González‐Prieto, Ana M. Muñoz-Cabello, María J. Cabello-Lobato, Félix Prado   +3 more
openalex   +1 more source

Opioid induces increased DNA damage in prefrontal cortex and nucleus accumbens

, 2023
Yunwanbin Wang, Archana Singh, Guohui Li, Shuwen Yue, Kegan Hertel, Zijun Wang   +5 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

The Influence of Clustered DNA Damage Containing Iz/Oz and ^OXOdG on the Charge Transfer through the Double Helix: A Theoretical Study

Molecules
The genome—the source of life and platform of evolution—is continuously exposed to harmful factors, both extra- and intra-cellular. Their activity causes different types of DNA damage, with approximately 80 different types of lesions having been ...
Bolesław T. Karwowski
doaj   +1 more source

The DNA-damage response in human biology and disease

Nature, 2009
S. Jackson, J. Bartek
semanticscholar   +1 more source