Results 171 to 180 of about 1,589,396 (359)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Genome stability of infants as measured by the Cytokinesis block micronucleus cytome assay and influence of type of feeding

Journal of Nutrition & Intermediary Metabolism, 2016
M. Singh, P. Thomas, M. Hor, W. Hague, J. Owens, M. Fenech   +5 more
doaj   +1 more source

Different rate-limiting steps in excision repair of ultraviolet- and N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human fibroblasts.

, 1977
Fahad Ahmed, R. B. Setlow
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Action Spectrum of Ultraviolet Light-Induced Damage to Nuclear Dna In Vivo**From the Department of Experimental Pathology and the Division of Dermatology, Scripps Clinic and Research FoundatiOn, La Jolla, California 92037 and the Department of Pathology, University of Texas, Southwestern Medical School, Dallas, Texas 75235.

, 1970
Eng M. Tan, Robert G. Freeman, Richard B. Stoughton   +2 more
openalex   +1 more source

Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium. [PDF]

, 1987
Gisela Storz, M F Christman, Helmut Sies, B N Ames   +3 more
openalex   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Hydroxyl radical production and DNA damage induced by anthracycline‐iron complex [PDF]

, 1984
Josephia R. Muindi, Birandra K. Sinha, Luca Gianni, Charles E. Myers   +3 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Repair of Ultraviolet Light Damage to the DNA of Cultured Human Epidermal Keratinocytes and Fibroblasts

, 1979
Lorne B. Taichman, R. B. Setlow
openalex   +1 more source