Results 311 to 320 of about 1,557,993 (359)

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors. [PDF]

Oncotarget
Qian H, Ali H, Karri V, Low JT, Ashley DM, Heimberger AB, Godley LA, Sonabend AM, Dmello C.   +8 more
europepmc   +1 more source

TIMELESS deficiency sensitizes thyroid cancer to cisplatin treatment via the DNA damage repair pathway. [PDF]

Transl Oncol
Wang C, Yuan P, Yang D, Liu B, Liang J.
europepmc   +1 more source

AlphaMissense for Identifying Pathogenic Missense Mutations in DNA Damage Repair Genes in Cancer. [PDF]

JCO Precis Oncol
Yazaki S, Pei X, Powell S, Khan A, Setton J, Riaz N.   +5 more
europepmc   +1 more source

Impact of cryopreservation on DNA damage in Acer platanoides L. seeds evaluated by the comet assay. [PDF]

Sci Rep
Plitta-Michalak BP, Ramos AA, Trusiak M, Ratajczak E, Michalak M.   +4 more
europepmc   +1 more source

DNA Damage by Fasicularin [PDF]

Journal of the American Chemical Society, 2005
Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5'-32P-labeled DNA duplex with fasicularin in pH 7.0 ...
Hideki Abe, Sakae Aoyagi, Sanjay Dutta, Chihiro Kibayashi, Kent S. Gates   +4 more
openaire   +2 more sources

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The DNA damaging revolution

Critical Reviews in Oncology/Hematology, 2020
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that plays a critical role in the repair of single-strand DNA damage via the base excision repair pathway. PARP inhibitors have substantial single-agent antitumor activity by inducing synthetic lethality.
Bulent Cetin, Chiara A. Wabl, Ozge Gumusay   +2 more
openaire   +3 more sources