Results 321 to 330 of about 1,557,993 (359)
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DNA Methyltransferases and DNA Damage
2022Ever since the discovery of depletion of CG sites in mammalian genomes it has been clear that cytosine DNA methyltransferases (DNMTs) are linked to the rate at which mutations accumulate in DNA. Research in the intervening decades has shown that DNMTs influence mutation rates through the indirect consequences of methylation on the mechanism of mutation
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Photochemistry and Photobiology, 1988
Abstract— The direct photomodification of DNA by ultraviolet light or the photo‐induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes.
Francis P. Gasparro, Regina M. Santella
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Abstract— The direct photomodification of DNA by ultraviolet light or the photo‐induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes.
Francis P. Gasparro, Regina M. Santella
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Current Opinion in Cell Biology, 2016
Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks.
Ivan Psakhye, Dana Branzei
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Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks.
Ivan Psakhye, Dana Branzei
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Mechanisms of Ageing and Development, 2004
The hypothesis discussed here is that a major component of aging in metazoans is oxidative damage to nuclear DNA. Such a viewpoint would be consistent with the fact that all of the thus far identified premature aging syndromes in mammals involve mutations in nuclear proteins.
Michael R. Lieber, Zarir E Karanjawala
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The hypothesis discussed here is that a major component of aging in metazoans is oxidative damage to nuclear DNA. Such a viewpoint would be consistent with the fact that all of the thus far identified premature aging syndromes in mammals involve mutations in nuclear proteins.
Michael R. Lieber, Zarir E Karanjawala
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2012
Carotenoids are among the best known antioxidant phytochemicals, and are widely believed to contribute to the health-promoting properties of fruits and vegetables. Investigations of the effects of carotenoids have been carried out at different levels: in cultured cells, in experimental animals, and in humans.
Andrew Collins, Amaya Azqueta
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Carotenoids are among the best known antioxidant phytochemicals, and are widely believed to contribute to the health-promoting properties of fruits and vegetables. Investigations of the effects of carotenoids have been carried out at different levels: in cultured cells, in experimental animals, and in humans.
Andrew Collins, Amaya Azqueta
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Current Opinion in Genetics & Development, 1996
DNA strand breaks are potentially mutagenic and must, therefore, be recognized and repaired. Recent work has identified DNA polymerase epsilon, Ku, and proteins such as DNA-PKcs, Mec1 and Tel1 as key players in DNA damage recognition pathways. Studies on these and other factors have provided important insights into the mechanisms of DNA repair and how ...
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DNA strand breaks are potentially mutagenic and must, therefore, be recognized and repaired. Recent work has identified DNA polymerase epsilon, Ku, and proteins such as DNA-PKcs, Mec1 and Tel1 as key players in DNA damage recognition pathways. Studies on these and other factors have provided important insights into the mechanisms of DNA repair and how ...
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DNA Damage and Polyploidization
2010A growing body of evidence indicates that polyploidization triggers chromosomal instability and contributes to tumorigenesis. DNA damage is increasingly being recognized for its roles in promoting polyploidization. Although elegant mechanisms known as the DNA damage checkpoints are responsible for halting the cell cycle after DNA damage, agents that ...
Chow, Jeremy Pak Hong +1 more
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Sperm DNA damage and its relation with leukocyte DNA damage
Reproductive Toxicology, 2010DNA fragmentation in human sperm has been related to endogenous and exogenous factors. Exogenous factors can also affect leukocyte DNA integrity. This study evaluated the relation between sperm DNA damage and leukocyte DNA integrity, as a predictor of exogenous factors.
Zahra Babazadeh +5 more
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DNA damage, repair and chromosomal damage
International Journal of Radiation Biology, 1997An important question in radiobiology is the relationship between primary DNA damage and chromosomal aberrations. What determines the chromosomal aberration frequency, especially in radiosensitive cells? Much evidence points to the double-strand break (dsb) as the critical lesion, however there is controversy over whether it is the initial induction ...
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1991
Some of the background to radiation chemical studies of DNA damage is presented, followed by a review of measurements of such damage and its repair in mammalian cells. While most effort has been placed on the measurement of radiation-induced strand breaks (because assays can be used in the biologically relevant dose range), the radiation-altered bases ...
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Some of the background to radiation chemical studies of DNA damage is presented, followed by a review of measurements of such damage and its repair in mammalian cells. While most effort has been placed on the measurement of radiation-induced strand breaks (because assays can be used in the biologically relevant dose range), the radiation-altered bases ...
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