Results 51 to 60 of about 5,698,803 (355)

Autophagy in DNA Damage Response [PDF]

, 2015
DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska, Janusz Blasiak, Jolanta Bialkowska-Warzecha, Kai Kaarniranta, Piotr Czarny   +4 more
core   +2 more sources

A qPCR-based assay to quantify oxidized guanine and other FPG-sensitive base lesions within telomeric DNA

BioTechniques, 2011
Telomere shortening is an important risk factor for cancer and accelerated aging. However, it is becoming evident that oxidatively damaged DNA within the telomere sequence may also cause telomere dysfunction.
Nathan O'Callaghan, Natalie Baack, Razinah Sharif, Michael Fenech   +3 more
doaj   +1 more source

Decreased MCM2-6 in Drosophila S2 cells does not generate significant DNA damage or cause a marked increase in sensitivity to replication interference. [PDF]

, 2011
A reduction in the level of some MCM proteins in human cancer cells (MCM5 in U20S cells or MCM3 in Hela cells) causes a rapid increase in the level of DNA damage under normal conditions of cell proliferation and a loss of viability when the cells are ...
A Ibarra, A Woodward, C Tsao, Christelle de Renty, D Cortez, Deanna Koepp, E Dorn, G Crevel, G Crevel, G Crevel, Gilles Crevel, H Mahbubani, Isabelle Crevel, M Edwards, M Lei, M Oehlmann, M Pacek, R Burkhart, R Laskey, R Marton, S Donovan, S Forsburg, Sue Cotterill, T Takahashi, Thierry Gostan, Vincent Coulon, X Ge, X Michalet, Y Daigaku, Y Ishimi   +29 more
core   +7 more sources

Radiation Type- and Dose-Specific Transcriptional Responses across Healthy and Diseased Mammalian Tissues

Antioxidants, 2022
Ionizing radiation (IR) is a genuine genotoxic agent and a major modality in cancer treatment. IR disrupts DNA sequences and exerts mutagenic and/or cytotoxic properties that not only alter critical cellular functions but also impact tissues proximal and
Eftychia Sagkrioti, Gökay Mehmet Biz, Işıl Takan, Seyedehsadaf Asfa, Zacharenia Nikitaki, Vassiliki Zanni, Rumeysa Hanife Kars, Christine E. Hellweg, Edouard I. Azzam, Stella Logotheti, Athanasia Pavlopoulou, Alexandros G. Georgakilas   +11 more
doaj   +1 more source

The 2Ih and ^OXOG Proximity Consequences on Charge Transfer through ds-DNA: Theoretical Studies of Clustered DNA Damage

Molecules, 2023
Genetic information is continuously exposed to harmful factors, both intra- and extracellular. Their activity can lead to the formation of different types of DNA damage. Clustered lesions (CDL) are problematic for DNA repair systems.
Boleslaw T. Karwowski
doaj   +1 more source

Pyrimido[1,2-a]-purin-10(3H)-one, M(1)G, is less prone to artifact than base oxidation [PDF]

, 2005
Pyrimido[1,2-a]-purin-10(3H)-one (M(1)G) is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose.
Jeong, Yo-Chan, Nakamura, Jun, Swenberg, James A., Upton, Patricia B.   +3 more
core   +3 more sources

DNA Damage/Repair Management in Cancers

Cancers, 2020
DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand.
Jehad F Alhmoud, J. Woolley, A. Al Moustafa, M. I. Malki   +3 more
semanticscholar   +1 more source

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Nature, 2017
Inflammatory gene expression following genotoxic cancer therapy is well documented, yet the events underlying its induction remain poorly understood. Inflammatory cytokines modify the tumour microenvironment by recruiting immune cells and are critical ...
S. Harding, Joseph L. Benci, J. Irianto, D. Discher, A. Minn, R. Greenberg   +5 more
semanticscholar   +1 more source

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]

, 2017
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie, Gilbertson, Matthew, Goldfarb, David S., Madrey, Joe, Millen, Jonathan, Nitiss, John L., Piazza, Gary A., Polevoda, Bogdan, Rapaport, Matan, Rasmussen, Lynn, Tombline, Gregory, Van Meter, Michael, Wennerberg, Kirster, White, E. Lucile   +13 more
core   +2 more sources

DNA Damage: From Threat to Treatment

Cells, 2020
DNA is the source of genetic information, and preserving its integrity is essential in order to sustain life. The genome is continuously threatened by different types of DNA lesions, such as abasic sites, mismatches, interstrand crosslinks, or single ...
Antonio Carusillo, C. Mussolino
semanticscholar   +1 more source