Results 51 to 60 of about 1,589,396 (359)

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]

, 2017
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie, Gilbertson, Matthew, Goldfarb, David S., Madrey, Joe, Millen, Jonathan, Nitiss, John L., Piazza, Gary A., Polevoda, Bogdan, Rapaport, Matan, Rasmussen, Lynn, Tombline, Gregory, Van Meter, Michael, Wennerberg, Kirster, White, E. Lucile   +13 more
core   +2 more sources

The Influence of 5′,8-Cyclo-2′-Deoxyguanosine on ds-DNA Charge Transfer Depends on Its Diastereomeric Form: A Theoretical Study

Antioxidants, 2023
The genetic information stored in the nucleobase sequence is continuously exposed to harmful extra- and intra-cellular factors, which can lead to different types of DNA damage, with more than 70 lesion types identified so far.
Bolesław T. Karwowski
doaj   +1 more source

“Tempe” Reduces Dna Damage in Rats Irradiated with Ultraviolet Ray [PDF]

, 2011
‘Tempe' is a popular Javanese-Indonesian tradisional food made of fermentedsoyabean. This study aims to examine whether ‘tempe', used as a strong anti-free,has the ability to decrease DNA damage induced by ultraviolet ray irirradiation inthe Wistar rats ...
Agus Bagiada, I Nyoman, Astawa, N. M. (Nyoman), Djelantik, A. A. (A), Maryam, S. (Siti)   +3 more
core  

Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]

, 2009
Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K., Davis, Molly L., Merino, Edward J.   +2 more
core   +2 more sources

How Clustered DNA Damage Can Change the Electronic Properties of ds-DNA—Differences between GAG, GA^OXOG, and ^OXOGA^OXOG

Biomolecules, 2023
Every 24 h, roughly 3 × 1017 incidences of DNA damage are generated in the human body as a result of intra- or extra-cellular factors. The structure of the formed lesions is identical to that formed during radio- or chemotherapy.
Boleslaw Karwowski
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

A sophisticated mechanism governs Pol ζ activity in response to replication stress

Nature Communications
DNA polymerase ζ (Pol ζ) plays an essential role in replicating damaged DNA templates but contributes to mutagenesis due to its low fidelity. Therefore, ensuring tight control of Pol ζ’s activity is critical for continuous and accurate DNA replication ...
Chun Li, Shuchen Fan, Pan Li, Yuzhen Bai, Ye Wang, Yueyun Cui, Mengdi Li, Ruru Wang, Yuan Shao, Yingying Wang, Shuo Zheng, Rong Wang, Lijun Gao, Miaomiao Li, Yuanyuan Zheng, Fengting Wang, Sihang Gao, Shiguo Feng, Jianing Wang, Xinqi Qu, Xialu Li   +20 more
doaj   +1 more source

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

eLife, 2019
Coordination of the cellular response to DNA damage is organised by multi-domain ‘scaffold’ proteins, including 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other proteins ...
Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver, Laurence H Pearl   +5 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source