Results 61 to 70 of about 5,360,965 (412)

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]

, 2012
The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma, Barthelmes, Danny Huylebroeck, Davies, Davies, El-Khamisy, El-Khamisy, El-Khamisy, El-Khamisy, Esguerra, Giovanella, Hirano, Hudson, Interthal, Interthal, Junko Murai, Katyal, Keith W. Caldecott, Ledesma, Liesbeth Vermeire, Lieve Umans, Limei Ju, Murai, Nitiss, Pommier, Pommier, Pype, Sherif F. El-Khamisy, Shunichi Takeda, Takashima, Varady, Vilotti, Yang, Yves Pommier, Zeng, Zhihong Zeng, Zhou   +36 more
core   +1 more source

m5C modification of mRNA serves a DNA damage code to promote homologous recombination

Nature Communications, 2020
Recruitment of DNA repair proteins to DNA damage sites is a critical step for DNA repair. Post-translational modifications of proteins at DNA damage sites serve as DNA damage codes to recruit specific DNA repair factors.
Hao Chen, Haibo Yang, Xiao-Long Zhu, Tribhuwan Yadav, Ouyang Jian, S. Truesdell, Jun Tan, Yumin Wang, Meihan Duan, Leizhen Wei, L. Zou, A. Levine, S. Vasudevan, Li Lan   +13 more
semanticscholar   +1 more source

How Clustered DNA Damage Can Change the Electronic Properties of ds-DNA—Differences between GAG, GA^OXOG, and ^OXOGA^OXOG

Biomolecules, 2023
Every 24 h, roughly 3 × 1017 incidences of DNA damage are generated in the human body as a result of intra- or extra-cellular factors. The structure of the formed lesions is identical to that formed during radio- or chemotherapy.
Boleslaw Karwowski
doaj   +1 more source

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]

, 2013
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz, Boyd, Breslin, Caldecott, Chen, Chiang, Ciccia, Dalhus, Das, Demple, Dungey, El-Khamisy, Fu, Godon, Hecht, Hegde, Hudson, Interthal, Interthal, Kato, Katyal, Kummar, Lebedeva, Lindahl, Lindahl, Liu, Loeb, Luo, Madhusudan, Meisenberg, Meryem Alagoz, Mohammed, Morland, Murai, Murai, Nilsen, Owen S. Wells, Pommier, Pourquier, Povirk, Ray Chaudhuri, Rydberg, Sherif F. El-Khamisy, Strom, Sultana, Takashima, Wilson, Xanthoudakis, Yang, Zeng, Zhou   +50 more
core   +1 more source

The Influence of 5′,8-Cyclo-2′-Deoxyguanosine on ds-DNA Charge Transfer Depends on Its Diastereomeric Form: A Theoretical Study

Antioxidants, 2023
The genetic information stored in the nucleobase sequence is continuously exposed to harmful extra- and intra-cellular factors, which can lead to different types of DNA damage, with more than 70 lesion types identified so far.
Bolesław T. Karwowski
doaj   +1 more source

Detailed analysis of the cell-inactivation mechanism by accelerated protons and light ions [PDF]

Phys. Med. Biol. 51 (2006) 1185-1199, 2005
Published survival data for V79 cells irradiated by monoenergetic protons, helium-3, carbon, and oxygen ions and for CHO cells irradiated by carbon ions have been analyzed using the probabilistic two-stage model of cell inactivation. Three different classes of DNA damages formed by traversing particles have been distinguished, namely severe single ...
arxiv   +1 more source

DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure [PDF]

, 2018
Delayed effects of sulfur mustard (SM) exposure on the levels of five important damage/repair proteins were investigated in 40 SM-exposed veterans of Iran-Iraq war and 35 unexposed controls.
Balali-Mood, Mahdi, Behravan, Effat, Blain, Peter, Jowsey, Paul, Khateri, Shahriar, Sadeghi, Mahmood, Soroush, Mohammad Reza, Williams, Faith   +7 more
core   +2 more sources

ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage [PDF]

, 2011
DNA polymerase η (polη) belongs to the Y-family of DNA polymerases and facilitates translesion synthesis past UV damage. We show that, after UV irradiation, polη becomes phosphorylated at Ser601 by the ataxia-telangiectasia mutated and Rad3-related (ATR)
Acharya, Alan R. Lehmann, Alao, Ammazzalorso, Bienko, Bienko, Biertümpfel, Catherine M. Green, Chen, Friedberg, Hoege, Johnson, Kannouche, Kannouche, Lehmann, Lehmann, Masutani, Masutani, McCulloch, Niimi, Ohmori, Pagès, Plosky, Prakash, Sabbioneda, Sabbioneda, Schmutz, Simone Sabbioneda, Stary, Stelter, Thomas Göhler, Tibbetts, Traven, Watanabe, Yuasa   +34 more
core   +2 more sources

Decreased MCM2-6 in Drosophila S2 cells does not generate significant DNA damage or cause a marked increase in sensitivity to replication interference. [PDF]

, 2011
A reduction in the level of some MCM proteins in human cancer cells (MCM5 in U20S cells or MCM3 in Hela cells) causes a rapid increase in the level of DNA damage under normal conditions of cell proliferation and a loss of viability when the cells are ...
A Ibarra, A Woodward, C Tsao, Christelle de Renty, D Cortez, Deanna Koepp, E Dorn, G Crevel, G Crevel, G Crevel, Gilles Crevel, H Mahbubani, Isabelle Crevel, M Edwards, M Lei, M Oehlmann, M Pacek, R Burkhart, R Laskey, R Marton, S Donovan, S Forsburg, Sue Cotterill, T Takahashi, Thierry Gostan, Vincent Coulon, X Ge, X Michalet, Y Daigaku, Y Ishimi   +29 more
core   +8 more sources

A sophisticated mechanism governs Pol ζ activity in response to replication stress

Nature Communications
DNA polymerase ζ (Pol ζ) plays an essential role in replicating damaged DNA templates but contributes to mutagenesis due to its low fidelity. Therefore, ensuring tight control of Pol ζ’s activity is critical for continuous and accurate DNA replication ...
Chun Li, Shuchen Fan, Pan Li, Yuzhen Bai, Ye Wang, Yueyun Cui, Mengdi Li, Ruru Wang, Yuan Shao, Yingying Wang, Shuo Zheng, Rong Wang, Lijun Gao, Miaomiao Li, Yuanyuan Zheng, Fengting Wang, Sihang Gao, Shiguo Feng, Jianing Wang, Xinqi Qu, Xialu Li   +20 more
doaj   +1 more source