Results 131 to 140 of about 976,559 (349)

New Mechanisms of DNA Repair Defects in Fused in Sarcoma–Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?

Journal of Experimental Neuroscience, 2019
Genome damage and defective DNA repair are etiologically linked to several neurodegenerative disorders, including fused in sarcoma (FUS)–associated amyotrophic lateral sclerosis (ALS).
Haibo Wang, Muralidhar L Hegde
doaj   +1 more source

Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents

OncoTarget, 2018
Introduction The goal of this study was to examine the effects of selinexor, an inhibitor of exportin-1 mediated nuclear export, on DNA damage repair and to evaluate the cytotoxic effects of selinexor in combination with DNA damaging agents (DDAs) in ...
T. Kashyap, C. Argueta, T. Unger, B. Klebanov, Sophia Debler, W. Senapedis, Marsha L. Crochiere, Margaret S. Lee, M. Kauffman, S. Shacham, Y. Landesman   +10 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability [PDF]

, 2006
DNA damage response mechanisms encompass pathways of DNA repair, cell cycle checkpoint arrest and apoptosis. Together, these mechanisms function to maintain genomic stability in the face of exogenous and endogenous DNA damage.
Ahnesorg, Buck, Calsou, Chappell, Chun, Cui, Difilippantonio, Dore, Fernandez-Capetillo, Frank, Gao, Gladdy, Hefferin, Hirao, Jeggo, Jeggo, Kemp, Kuhne, Kurz, Lavin, Lee, Liu, Lobrich, Lukas, Ma, Markus Löbrich, Moshous, Moshous, Nick McElhinny, Penny A. Jeggo, Poinsignon, Riballo, Rooney, Rothkamm, Stankovic, Stankovic, Terzoudi, Walker, Wang, Weterings, Wyman, Zhang   +41 more
core   +1 more source

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair

Scientific Reports, 2018
The chromosome 21 encoded protein kinase DYRK1A is essential for normal human development. Mutations in DYRK1A underlie a spectrum of human developmental disorders, and increased dosage in trisomy 21 is implicated in Down syndrome related pathologies ...
S. Guard, Zachary C. Poss, Christopher C. Ebmeier, Maria Pagratis, Helen Simpson, D. Taatjes, W. Old   +6 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Cancers, 2017
Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a higher relative biological effectiveness (RBE).
O. Mohamad, Brock J. Sishc, Janapriya Saha, A. Pompoš, A. Rahimi, M. Story, A. Davis, D.W. Nathan Kim   +7 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Interplay of space radiation and microgravity in DNA damage and DNA damage response [PDF]

, 2017
In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms.
Lu, Tao, Moreno-Villanueva, María, Wong, Michael, Wu, Honglu, Zhang, Ye   +4 more
core   +2 more sources

OxyS small RNA induces cell cycle arrest to allow DNA damage repair

EMBO Journal, 2017
To maintain genome integrity, organisms employ DNA damage response, the underlying principles of which are conserved from bacteria to humans. The bacterial small RNA OxyS of Escherichia coli is induced upon oxidative stress and has been implicated in ...
Shir Barshishat, Maya Elgrably-Weiss, Jonathan Edelstein, J. Georg, S. Govindarajan, Meytal Haviv, Patrick R. Wright, W. Hess, S. Altuvia   +8 more
semanticscholar   +1 more source