Results 311 to 320 of about 976,559 (349)
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2017
DNA damage, when occurring in cancer-related genes, may lead to tumorigenesis. In normal cells, such DNA alterations activate a complex machinery of DNA damage repair. Genomic defects in DNA damage repair genes are known to be major drivers of cancer development and progression, in particular in breast and colon cancer.
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DNA damage, when occurring in cancer-related genes, may lead to tumorigenesis. In normal cells, such DNA alterations activate a complex machinery of DNA damage repair. Genomic defects in DNA damage repair genes are known to be major drivers of cancer development and progression, in particular in breast and colon cancer.
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Introduction: DNA Damage and Repair
1983The concept that cancer may be induced by the interaction of a carcinogen with DNA is widely accepted, although it is becoming increasingly clear that some carcinogens do not interact with DNA to a detectable extent. The carcinogens have been classified into two broad categories, genotoxic and non-genotoxic or epigenetic.
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2010
Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity.
Hammond, E.M. +2 more
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Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity.
Hammond, E.M. +2 more
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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Nature, 2007Derrick J. Rossi +5 more
semanticscholar +1 more source
Radiation therapy‐associated toxicity: Etiology, management, and prevention
Ca-A Cancer Journal for Clinicians, 2021Kyle Wang
exaly
1978
ABSTRACT Important contributions to the elucidation of the role of DNA repair for cell viability, mutagenesis, malignant transformation and cell degeneration are expected from experiments in which individual DNA lesions of known chemical structure are investigated.
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ABSTRACT Important contributions to the elucidation of the role of DNA repair for cell viability, mutagenesis, malignant transformation and cell degeneration are expected from experiments in which individual DNA lesions of known chemical structure are investigated.
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Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review
Ca-A Cancer Journal for Clinicians, 2022Deborah C Marshall, Mas +2 more
exaly
Antibiotic-induced collateral damage to the microbiota and associated infections
Nature Reviews Microbiology, 2023Laura de Nies +2 more
exaly
Ultraviolet radiation: DNA damage, repair, and human disorders
Molecular & Cellular Toxicology, 2017Sung-Lim Yu, Sung‐Keun Lee
semanticscholar +1 more source