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ARHGAP11A, a member of Rho GTPase activating protein family, as a prognostic biomarker linked to DNA damage response across pan-cancer. [PDF]

BMC Cancer
Tan K, Wu Y, Zhang J, Ding Y, Cheng C, Yan Z, Wang X, Zhang L.   +7 more
europepmc   +1 more source

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Nature, 2006
Shideng Bao, Qiulian Wu, Roger E Mclendon   +2 more
exaly   +2 more sources

The DNA damage response to transcription stress

Nature Reviews Molecular Cell Biology, 2019
Hannes Lans, Jan H J Hoeijmakers, Wim Vermeulen   +2 more
exaly   +2 more sources

DNA Damage Response in Nucleoli

Molecular Biology, 2021
Nucleoli, the largest subnuclear compartments, are formed around arrays of ribosomal gene repeats transcribed by RNA polymerase I. The primary function of nucleoli is ribosome biogenesis. Specific DNA damage response mechanisms exist to maintain the genomic stability of ribosomal repeats.
A K, Velichko, S V, Razin, O L, Kantidze
openaire   +2 more sources

Cellular Response to DNA Damage

Annals of the New York Academy of Sciences, 2006
Abstract: Eukaryotic cells, from yeast to man, possess evolutionarily conserved mechanisms to accurately and efficiently repair the overwhelming majority of DNA damage, thereby ensuring genomic integrity. Important repair pathways include base excision repair, nucleotide excision repair, mismatch repair, non‐homologous end‐joining, and homologous ...
Johnny, Kao, Barry S, Rosenstein, Sheila, Peters, Michael T, Milano, Stephen J, Kron   +4 more
openaire   +2 more sources

DNA damage response and transcription

DNA Repair, 2011
A network of DNA damage surveillance systems is triggered by sensing of DNA lesions and the initiation of a signal transduction cascade that activates genome-protection pathways including nucleotide excision repair (NER). NER operates through coordinated assembly of repair factors into pre- and post-incision complexes.
Lagerwerf, S., Vrouwe, M.G., Overmeer, R.M., Fousteri, M.I., Mullenders, L.H.F.   +4 more
openaire   +3 more sources

DNA damage response and neuroprotection

Frontiers in Bioscience, 2008
The protection of genomic integrity is a major challenge for living cells that are continuously exposed to endogenous and environmental DNA-damaging insults. To cope with the consequences of DNA lesions which interfere with essential DNA-dependent processes including transcription and replication, cells are equipped with an efficient defense mechanism ...
Inna I, Kruman, Elena I, Schwartz
openaire   +2 more sources

Mammalian DNA Damage Response Pathway

2006
The DNA damage response pathway is critical for the maintenance of genomic stability. Many components of this pathway are tumour suppressors, such as p53, ATM, BRCA1, NBS1, Mre11 and Chk2, underlining the critical role of the DNA damage response pathway in tumour suppression.
Zhenkun, Lou, Junjie, Chen
openaire   +2 more sources

Transcriptional responses to DNA damage

Current Opinion in Microbiology, 2001
In Escherichia coli, DNA repair and protective responses are regulated at the transcriptional level. Regulatory mechanisms have evolved that allow cells to respond to DNA damage by mounting the appropriate responses. The regulatory proteins controlling these responses are activated when they recognize the presence of a specific DNA damaging agent, the ...
M R, Volkert, P, Landini
openaire   +2 more sources