Results 351 to 360 of about 1,846,477 (392)
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RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression
Journal of Cellular Physiology, 2019Mitogenâactivated protein kinase (MAPK) signaling pathways organize a great constitution network that regulates several physiological processes, like cell growth, differentiation, and apoptotic cell death.
Setareh Rezatabar +10 more
semanticscholar +1 more source
The DNA damage response during DNA replication
Current Opinion in Cell Biology, 2005Eukaryotic chromosome replication is mediated by multiple replicons and is coordinated with sister chromatid cohesion, DNA recombination, transcription and cell cycle progression. Replication forks stall or collapse at DNA lesions or problematic genomic regions, and these events have often been associated with recombination and chromosomal ...
M. Foiani, D. Branzei
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DNA damage response pathway in radioadaptive response
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2002Radioadaptive response is a biological defense mechanism in which low-dose ionizing irradiation elicits cellular resistance to the genotoxic effects of subsequent irradiation. However, its molecular mechanism remains largely unknown. We previously demonstrated that the dose recognition and adaptive response could be mediated by a feedback signaling ...
Masao S, Sasaki +6 more
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Cellular responses to DNA damage
Current Opinion in Cell Biology, 1998The exposure of cells to DNA damage inducers triggers a wide range of cellular responses including an alteration in gene expression, a delay in cell-cycle progression and the stimulation of DNA repair. In multicellular organisms, DNA damage can also activate programmed cell death.
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Aurora kinases and DNA damage response
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2020It is well established that Aurora kinases perform critical functions during mitosis. It has become increasingly clear that the Aurora kinases also perform a myriad of non-mitotic functions including DNA damage response. The available evidence indicates that inhibition Aurora kinase A (AURKA) may contribute to the G2 DNA damage checkpoint through AURKA'
Ma, Hoi Tang, Poon, Randy Y. C.
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Targeting DNA damage response pathways in cancer
Nature Reviews. Cancer, 2022Florian J. Groelly +4 more
semanticscholar +1 more source
Science Signaling, 2011
A screen identifies proteins not previously known to function in protecting cells from DNA damage.
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A screen identifies proteins not previously known to function in protecting cells from DNA damage.
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Targeting the DNA damage response in immuno-oncology: developments and opportunities
Nature Reviews. Cancer, 2021R. Chabanon +5 more
semanticscholar +1 more source
Science's STKE, 2007
DNA damage is often a key event in triggering malignancy (see the Perspective by Petrini). Much of the cellular response to DNA damage is mediated by two protein kinases, ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related kinase). Matsuoka et al .
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DNA damage is often a key event in triggering malignancy (see the Perspective by Petrini). Much of the cellular response to DNA damage is mediated by two protein kinases, ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related kinase). Matsuoka et al .
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The DNA damage response: putting checkpoints in perspective
Nature, 2000Bin-Bing S. Zhou, S. Elledge
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