Results 41 to 50 of about 1,519,960 (260)

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex

EMBO Reports
mTOR (mechanistic target of rapamycin) kinase is a pivotal regulator of cellular growth and metabolism, integrating signals from nutrients and growth factors. It functions through the assembly of two distinct complexes, mTORC1 and mTORC2, which differ in
Keshav Gupta, Nagalakshmi Kommineni, Tanuja Bogadi, Neeraja P Alamuru-Yellapragada, Subbareddy Maddika   +4 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Stalk architecture, cell wall composition, and QTL underlying high stalk flexibility for improved lodging resistance in maize

BMC Plant Biology, 2020
Background Stalk fracture caused by strong wind can severely reduce yields in maize. Stalks with higher stiffness and flexibility will exhibit stronger lodging resistance. However, stalk flexibility is rarely studied in maize.
Xiaqing Wang, Zi Shi, Ruyang Zhang, Xuan Sun, Jidong Wang, Shuai Wang, Ying Zhang, Yanxin Zhao, Aiguo Su, Chunhui Li, Ronghuan Wang, Yunxia Zhang, Shuaishuai Wang, Yuandong Wang, Wei Song, Jiuran Zhao   +15 more
doaj   +1 more source

Screening of 200 Core SNPs and the Construction of a Systematic SNP-DNA Standard Fingerprint Database with More Than 20,000 Maize Varieties

Agriculture, 2021
To strengthen the management of maize varieties and the protection of intellectual property rights to new varieties, we constructed a comprehensive single nucleotide polymorphism (SNP)-DNA standard fingerprint database of 20,075 materials covering ...
Hongli Tian, Yang Yang, Rui Wang, Yaming Fan, Hongmei Yi, Bin Jiang, Lu Wang, Jie Ren, Liwen Xu, Yunlong Zhang, Jianrong Ge, Yawei Liu, Fengge Wang, Jiuran Zhao   +13 more
doaj   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

DNA fingerprinting.

, 2000
With the increasing need in the accuracy of the forensic process, DNA fingerprinting becomes the most widely used technique in material-evidence analysis, allowing forensic scientists to accurately confirm or deny any forensic relationship in question ...
Han, Yi, Winter, William Andrew, Thanesvorakul, Sirinart, Wong, Joey   +3 more
core   +3 more sources

A High-Performance Database Management System for Managing and Analyzing Large-Scale SNP Data in Plant Genotyping and Breeding Applications

Agriculture, 2021
A DNA fingerprint database is an efficient, stable, and automated tool for plant molecular research that can provide comprehensive technical support for multiple fields of study, such as pan-genome analysis and crop breeding.
Yikun Zhao, Bin Jiang, Yongxue Huo, Hongmei Yi, Hongli Tian, Haotian Wu, Rui Wang, Jiuran Zhao, Fengge Wang   +8 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Prevalence and characterisation of size and sequence-based microvariant alleles at nine autosomal STR markers in the Central Indian population

Annals of Human Biology, 2021
Background Though microvariant alleles are widely reported in global populations, they are not well characterised to date. Aim To study the prevalence and characterisation of size and sequence-based microvariant alleles Subjects and methods Next ...
Hirak Ranjan Dash, Kamayani Vajpayee, Ankit Srivastava, Surajit Das   +3 more
doaj   +1 more source