Results 1 to 10 of about 270,206 (261)

Rapid single nucleotide polymorphism mapping in C. elegans [PDF]

BMC Genomics, 2005
Background In C. elegans, single nucleotide polymorphisms (SNPs) can function as silent genetic markers, with applications ranging from classical two- and three-factor mapping to measuring recombination across whole chromosomes. Results Here, we describe
Hullett Patrick, Harrach Tracey, Hammarlund Marc, Davis M Wayne, Olsen Shawn, Jorgensen Erik M   +5 more
doaj   +3 more sources

Mapping recently identified nucleotide variants in the genome and transcriptome [PDF]

Nature Biotechnology, 2012
Nucleotide variants, especially those related to epigenetic functions, provide critical regulatory information beyond simple genomic sequence, and they define cell status in higher organisms. 5-Methylcytosine, which is found in DNA, was until recently the only nucleotide variant studied in terms of epigenetics in eukaryotes.
Chun-Xiao Song, Chengqi Yi, Chuan He
exaly   +4 more sources

Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse

PLoS Biology, 2004
Rapid expansion of available data, both phenotypic and genotypic, for multiple strains of mice has enabled the development of new methods to interrogate the mouse genome for functional genetic perturbations. In silico mapping provides an expedient way to associate the natural diversity of phenotypic traits with ancestrally inherited polymorphisms for ...
Tim Wiltshire, Sergey Batalov, Ron Korstanje   +2 more
exaly   +5 more sources

Development of tri-nucleotide microsatellite markers from Crassostrea hongkongensis using enriched genomic libraries and cross-species amplification in two closely related species

Aquaculture Reports, 2021
An enrichment protocol was used to isolate and characterize tri-nucleotide microsatellite markers in Crassostrea hongkongensis, an economically important and extensively cultured oyster species along the southern coastal areas of China.
Haitao Ma, Yuehuan Zhang, Zhiming Xiang, Yang Zhang, Yanping Qin, Ziniu Yu   +5 more
doaj   +1 more source

Autozygosity Mapping by Genome-wide Single Nucleotide Polymorphism Array Identifies a Novel Homozygous HR Mutation in a Consanguineous Family with Universal Hereditary Hair Loss

International Journal of Dermatology and Venerology, 2021
. Objective:. Isolated hereditary hypotrichosis is caused by mutations in as many as 11 different genes. The conventional mutation detection strategy consists of sequencing of individual candidate genes separately, a time consuming and costly approach ...
Sirous Zeinali, Leila Youssefian, Hassan Vahidnezhad, Amir Hossein Saeidian, Soheila Sotoudeh, Hamideh Bagherian, Jouni Uitto   +6 more
doaj   +1 more source

Metagenomic surveillance for bacterial tick-borne pathogens using nanopore adaptive sampling

Scientific Reports, 2023
Technological and computational advancements in the fields of genomics and bioinformatics are providing exciting new opportunities for pathogen discovery and genomic surveillance.
Evan J. Kipp, Laramie L. Lindsey, Benedict Khoo, Christopher Faulk, Jonathan D. Oliver, Peter A. Larsen   +5 more
doaj   +1 more source

Complex Feline Disease Mapping Using a Dense Genotyping Array

Frontiers in Veterinary Science, 2022
The current feline genotyping array of 63 k single nucleotide polymorphisms has proven its utility for mapping within breeds, and its use has led to the identification of variants associated with Mendelian traits in purebred cats.
Isabel Hernandez, Jessica J. Hayward, Jeff A. Brockman, Michelle E. White, Michelle E. White, Lara Mouttham, Elizabeth A. Wilcox, Susan Garrison, Marta G. Castelhano, John P. Loftus, Filipe Espinheira Gomes, Cheryl Balkman, Marjory B. Brooks, Nadine Fiani, Marnin Forman, Tom Kern, Bruce Kornreich, Eric C. Ledbetter, Santiago Peralta, Angela M. Struble, Lisa Caligiuri, Elizabeth Corey, Lin Lin, Julie Jordan, Danny Sack, Adam R. Boyko, Leslie A. Lyons, Rory J. Todhunter   +27 more
doaj   +1 more source

Mapping of psoralen cross-linked nucleotides in RNA [PDF]

Nucleic Acids Research, 1984
A method is described for using the cross-linking reagent 4'-(hydroxy-methyl)-4,5',8-trimethylpsoralen (HMT) to map base paired regions and higher-order structure within RNA molecules. Applying this method to yeast tRNAPhe, we have specifically identified cross-links within the acceptor stem between U6 X U68, in the D-stem between C11 X C25, and in the
E, Garrett-Wheeler, R E, Lockard, A, Kumar   +2 more
openaire   +2 more sources

Fast genetic mapping using insertion-deletion polymorphisms in Caenorhabditis elegans

Scientific Reports, 2021
Genetic mapping is used in forward genetics to narrow the list of candidate mutations and genes corresponding to the mutant phenotype of interest. Even with modern advances in biology such as efficient identification of candidate mutations by whole ...
Ho-Yon Hwang, Jiou Wang
doaj   +1 more source

Mapping of Complex Traits by Single-Nucleotide Polymorphisms [PDF]

The American Journal of Human Genetics, 1998
Molecular geneticists are developing the third-generation human genome map with single-nucleotide polymorphisms (SNPs), which can be assayed via chip-based microarrays. One use of these SNP markers is the ability to locate loci that may be responsible for complex traits, via linkage/linkage-disequilibrium analysis.
Zhao, Lue Ping, Aragaki, Corinne, Hsu, Li, Quiaoit, Filemon   +3 more
openaire   +2 more sources