Results 11 to 20 of about 270,206 (261)
Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing [PDF]
Nature CommunicationsRibosome biogenesis requires the synthesis and sequential processing of precursor rRNAs (pre-rRNAs) into mature rRNAs. Traditional methods such as northern blotting and metabolic labeling provide limited resolution.
Stefan Pastore +8 more
doaj +2 more sources
Quantitative PCR approach to SNP detection and linkage mapping in Caenorhabditis elegans
BioTechniques, 2006 I report a method for single nucleotide polymorphism (SNP) detection and linkage mapping in Caenorhabditis elegans using automated oligonucleotide design and fluorescence-based quantitative PCR detection.
Christopher A. Shelton
doaj +1 more source
Optimizing the GATA-3 position weight matrix to improve the identification of novel binding sites
BMC Genomics, 2012 Background The identifying of binding sites for transcription factors is a key component of gene regulatory network analysis. This is often done using position-weight matrices (PWMs).
Nandi Soumyadeep, Ioshikhes Ilya
doaj +1 more source
Single nucleotide polymorphisms (SNPs) that map to gaps in the human SNP map [PDF]
Nucleic Acids Research, 2003 An international effort is underway to generate a comprehensive haplotype map (HapMap) of the human genome represented by an estimated 300,000 to 1 million 'tag' single nucleotide polymorphisms (SNPs). Our analysis indicates that the current human SNP map is not sufficiently dense to support the HapMap project.
Circe, Tsui +7 more
openaire +2 more sources
Nucleotide Analog Interference Mapping
Methods, 1999 Single-atom substitution experiments provide atomic resolution biochemical information concerning RNA structure and function. Traditionally, these experiments are performed using chimeric RNAs generated by reassembly of full-length RNA from a synthetic substituted oligonucleotide and a truncated RNA transcript.
S P, Ryder, S A, Strobel
openaire +2 more sources
TraV: a genome context sensitive transcriptome browser.
PLoS ONE, 2014 Next-generation sequencing (NGS) technologies like Illumina and ABI Solid enable the investigation of transcriptional activities of genomes. While read mapping tools have been continually improved to enable the processing of the increasing number of ...
Sascha Dietrich +2 more
doaj +1 more source
Nucleotide ‘maps’ of digests of deoxyribonucleic acid [PDF]
Biochemical Journal, 1970 Various digests of 32P-labelled DNA were examined by two-dimensional ionophoresis on cellulose acetate and DEAE-cellulose paper. The products from digestion with pancreatic deoxyribonuclease and Neurospora crassa endonuclease were qualitatively closely similar, but very complex, and were used to investigate the mapping behaviour of nucleotides in ...
openaire +2 more sources
Identification of potential small molecule binding pockets on Rho family GTPases. [PDF]
PLoS ONE, 2012 Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is
Juan Manuel Ortiz-Sanchez +5 more
doaj +1 more source
Nucleotide sequence-directed mapping of the nucleosomes
Nucleic Acids Research, 1983 The concept of sequence-dependent deformational anisotropy of DNA proposed earlier is further elaborated and a computational procedure is developed for the sequence-directed mapping of the nucleosomes along chromatin DNA nucleotide sequences. The deformational anisotropy is found to be nonuniform along the molecule of the nucleosomal DNA, suggesting ...
G, Mengeritsky, E N, Trifonov
openaire +3 more sources
Plants, 2021 Previous genetic mapping helped detect a ~7.52 Mb putative genomic region for the pollen fertility trait on peach Chromosome 06 (Chr.06), which was too long for candidate gene characterization.
Zhenyu Huang +4 more
doaj +1 more source