Results 11 to 20 of about 458,823 (303)
A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder [PDF]
, 2005 Homozygosity mapping is a very powerful method for finding rare recessive disease genes in monogenic disorders and may also be useful for locating risk genes in complex disorders, late onset disorders where parents often are not available, and for rare ...
American Psychiatric Association +21 more
core +1 more source
Mapping of psoralen cross-linked nucleotides in RNA [PDF]
Nucleic Acids Research, 1984 A method is described for using the cross-linking reagent 4'-(hydroxy-methyl)-4,5',8-trimethylpsoralen (HMT) to map base paired regions and higher-order structure within RNA molecules. Applying this method to yeast tRNAPhe, we have specifically identified cross-links within the acceptor stem between U6 X U68, in the D-stem between C11 X C25, and in the
E, Garrett-Wheeler +2 more
openaire +2 more sources
BamView: visualizing and interpretation of next-generation sequencing read alignments. [PDF]
, 2012 So-called next-generation sequencing (NGS) has provided the ability to sequence on a massive scale at low cost, enabling biologists to perform powerful experiments and gain insight into biological processes.
Berriman, Matthew +5 more
core +1 more source
Mapping of Complex Traits by Single-Nucleotide Polymorphisms [PDF]
The American Journal of Human Genetics, 1998 Molecular geneticists are developing the third-generation human genome map with single-nucleotide polymorphisms (SNPs), which can be assayed via chip-based microarrays. One use of these SNP markers is the ability to locate loci that may be responsible for complex traits, via linkage/linkage-disequilibrium analysis.
Zhao, Lue Ping +3 more
openaire +2 more sources
Local Binary Patterns as a Feature Descriptor in Alignment-free Visualisation of Metagenomic Data [PDF]
, 2016 Shotgun sequencing has facilitated the analysis of complex microbial communities. However, clustering and visualising these communities without prior taxonomic information is a major challenge.
Kouchaki, Samaneh +3 more
core +1 more source
TraV: a genome context sensitive transcriptome browser.
PLoS ONE, 2014 Next-generation sequencing (NGS) technologies like Illumina and ABI Solid enable the investigation of transcriptional activities of genomes. While read mapping tools have been continually improved to enable the processing of the increasing number of ...
Sascha Dietrich +2 more
doaj +1 more source
Identification of potential small molecule binding pockets on Rho family GTPases. [PDF]
PLoS ONE, 2012 Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is
Juan Manuel Ortiz-Sanchez +5 more
doaj +1 more source
Plants, 2021 Previous genetic mapping helped detect a ~7.52 Mb putative genomic region for the pollen fertility trait on peach Chromosome 06 (Chr.06), which was too long for candidate gene characterization.
Zhenyu Huang +4 more
doaj +1 more source
Mapping complex traits with single nucleotide polymorphisms [PDF]
Nature Genetics, 1999 Molecular geneticists are developing the third generation human genome map with single nucleotide polymorphisms (SNPs), which can be assayed through chip-based microarrays. One use of these SNP markers is to locate loci that may be responsible for complex traits through linkage/linkage-disequilibrium analysis.
Lue Ping Zhao +3 more
openaire +1 more source
Single Nucleotide Polymorphism Identification, Characterization, and Linkage Mapping in Quinoa
The Plant Genome, 2012 Quinoa ( Willd.) is an important seed crop throughout the Andean region of South America. It is important as a regional food security crop for millions of impoverished rural inhabitants of the Andean Altiplano (high plains).
P. J. Maughan +8 more
doaj +1 more source