Results 41 to 50 of about 1,708,901 (308)

Population structure and association mapping studies for yield-related traits in Maize (Zea mays L.)

Current Plant Biology, 2019
Association mapping is an efficient approach for dissecting the genetic architecture of yield-related traits using single nucleotide polymorphism (SNP) markers in maize. The present study was carried out with a set of 93 diverse maize accessions with the
S. Sivakumar, M. Dhasarathan, A. Karthikeyan, P. Bharathi, N. Kumari vinodhana, K. Ganesamurthy, N. Senthil   +6 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Mapping ribonucleotides embedded in genomic DNA to single-nucleotide resolution using Ribose-Map [PDF]

Nature Protocols, 2020
ABSTRACT Ribose-Map is a user-friendly, standardized bioinformatics toolkit for the comprehensive analysis of ribonucleotide sequencing experiments. It allows researchers to map the locations of ribonucleotides in DNA to single-nucleotide resolution and identify biological signatures of ribonucleotide incorporation.
Alli L. Gombolay, Francesca Storici
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome [PDF]

Nature Methods, 2015
N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches localize m6A residues to transcript regions 100-200 nt long but cannot identify precise m6A positions on a transcriptome-wide level. Here we developed m6A individual-nucleotide-resolution cross-
Linder, Bastian, Grozhik, Anya V., Olarerin-George, Anthony O., Meydan, Cem, Mason, Christopher E., Jaffrey, Samie R.   +5 more
openaire   +2 more sources

High-throughput isolation and mapping of C. elegans mutants susceptible to pathogen infection. [PDF]

PLoS ONE, 2008
We present a novel strategy that uses high-throughput methods of isolating and mapping C. elegans mutants susceptible to pathogen infection. We show that C.
Laura E Fuhrman, Kevin V Shianna, Alejandro Aballay   +2 more
doaj   +1 more source

A pipeline for high throughput detection and mapping of SNPs from EST databases [PDF]

, 2010
Single nucleotide polymorphisms (SNPs) represent the most abundant type of genetic variation that can be used as molecular markers. The SNPs that are hidden in sequence databases can be unlocked using bioinformatic tools.
C. Gerard van der Linden, Anithakumari, A.M., Jack A. M. Leunissen, Richard G. F. Visser, Eck, H.J., van, A. M. Anithakumari, van Eck, H.J., Vosman, B., Visser, R.G.F., Tang, Jifeng, Herman J. van Eck, Leunissen, J.A.M., van der Linden, C.G., Linden, C.G., van der, Jifeng Tang, Ben Vosman   +15 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Genome-wide mapping of nucleotide excision repair with XR-seq [PDF]

Nature Protocols, 2018
Nucleotide excision repair is a versatile mechanism to repair a variety of bulky DNA adducts. We developed excision repair sequencing (XR-seq) to study nucleotide excision repair of DNA adducts in humans, mice, Arabidopsis thaliana, yeast and Escherichia coli. In this protocol, the excised oligomers, generated in the nucleotide excision repair reaction,
Jinchuan Hu, Wentao Li, Ogun Adebali, Yanyan Yang, Onur Oztas, Christopher P. Selby, Aziz Sancar   +6 more
openaire   +4 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source