Results 41 to 50 of about 280,333 (306)

Exploring structural variation and gene family architecture with De Novo assemblies of 15 Medicago genomes

BMC Genomics, 2017
Background Previous studies exploring sequence variation in the model legume, Medicago truncatula, relied on mapping short reads to a single reference.
Peng Zhou, Kevin A. T. Silverstein, Thiruvarangan Ramaraj, Joseph Guhlin, Roxanne Denny, Junqi Liu, Andrew D. Farmer, Kelly P. Steele, Robert M. Stupar, Jason R. Miller, Peter Tiffin, Joann Mudge, Nevin D. Young   +12 more
doaj   +1 more source

NMR Studies of Retroviral Genome Packaging

Viruses, 2020
Nearly all retroviruses selectively package two copies of their unspliced RNA genomes from a cellular milieu that contains a substantial excess of non-viral and spliced viral RNAs.
Patricia S. Boyd, Janae B. Brown, Joshua D. Brown, Jonathan Catazaro, Issac Chaudry, Pengfei Ding, Xinmei Dong, Jan Marchant, Colin T. O’Hern, Karndeep Singh, Canessa Swanson, Michael F. Summers, Saif Yasin   +12 more
doaj   +1 more source

A structural map of oncomiR-1 at single-nucleotide resolution [PDF]

Nucleic Acids Research, 2017
The miR-17-92a cluster, also known as 'oncomiR-1', is an RNA transcript that plays a pivotal regulatory role in cellular processes, including the cell cycle, proliferation and apoptosis. Its dysregulation underlies the development of several cancers. Oncomir-1 comprises six constituent miRNAs, each processed with different efficiencies as a function of
Saikat Chakraborty, Yamuna Krishnan
openaire   +2 more sources

Nucleotide-Resolution Genome-Wide Mapping of Oxidative DNA Damage by Click-Code-Seq

, 2018
Single-nucleotide-resolution sequencing of DNA damage is required to decipher the complex causal link between the identity and location of DNA adducts and their biological impact.
Maureen McKeague (1313472), Junzhou Wu (582560), Sturla, Shana J.; id_orcid, McKeague, Maureen; id_orcid, Wu, Junzhou, Shana J. Sturla (1472944)   +5 more
core   +1 more source

Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA [PDF]

Cold Spring Harbor Perspectives in Biology, 2019
An important mechanism of gene expression regulation is the regulated modification of nucleotides in messenger RNA (mRNA). These modified nucleotides affect mRNA translation, stability, splicing, and other processes. A cluster of nucleotide modifications is found adjacent to the mRNA cap structure and another set can be found internally within ...
Bastian, Linder, Samie R, Jaffrey
openaire   +2 more sources

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type I diabetes.

, 2005
BACKGROUND: One strategy to help identify susceptibility genes for complex, multifactorial diseases is to map disease loci in a representative animal model of the disorder. The nonobese diabetic (NOD) mouse is a model for human type 1 diabetes.
Undlien, Dag E, Lowe, C, Chamberlain, G, Savage, DA, Undlien, DE, Wicker, LS, Hunter, Kara M, Walker Neil, Wicker Linda S, Ionescu-Tîrgovişte, Constantin, Maier, Lisa M, Savage, David A, Fraser, H, Guja Cristian, Nutland Sarah, Vella, Adrian, Fraser, Heather, Nutland, Sarah, Moule, Carolyn, Payne, Felicity, Nutland, S, Maier, LM, Todd John A, Twells Rebecca C, Guja, Cristian, Twells, RC, Cooper, Jason D, Ionescu-Tîrgovişte Constantin, Maier Lisa M, Rønningen, Kjersti S, Payne Felicity, Moule Carolyn, Savage David A, Pask, Rebecca, Smyth Deborah J, Strachan, David P, Chamberlain Giselle, Twells, Rebecca C, Smink, LJ, Todd, John A, Hulme, J, Hunter Kara M, Vella, A, Hulme John, Hunter, KM, Lowe, Christopher, Wicker, Linda S, Walker, N, Lowe Christopher, Smyth, DJ, Peterson, LB, Smink, Luc J, Rønningen, KS, Smyth, Deborah J, Cooper Jason D, Strachan David P, Ionescu-Tîrgoviste, C, Payne, F, Pask Rebecca, Strachan, DP, Undlien Dag E, Hulme, John, Vella Adrian, Guja, C, Smink Luc J, Pask, R, Walker, Neil, Moule, C, Todd, JA, Fraser Heather, Rønningen Kjersti S, Chamberlain, Giselle, Peterson Laurence B, Cooper, JD, Peterson, Laurence B   +74 more
core   +1 more source

Evolutionary strata on the X chromosomes of the dioecious plant Silene latifolia: Evidence from new sex-linked genes [PDF]

, 2007
Despite its recent evolutionary origin, the sex chromosome system of the plant Silene latifolia shows signs of progressive suppression of recombination having created evolutionary strata of different X-Y divergence on sex chromosomes. However, even after
Bergero, Roberta, Forrest, Alan, Kamau, Esther, Charlesworth, Deborah   +3 more
core   +1 more source

Development and characterization of genomic and expressed SSRs in citrus by genome-wide analysis. [PDF]

PLoS ONE, 2013
Microsatellites or simple sequence repeats (SSRs) are one of the most popular sources of genetic markers and play a significant role in plant genetics and breeding.
Sheng-Rui Liu, Wen-Yang Li, Dang Long, Chun-Gen Hu, Jin-Zhi Zhang   +4 more
doaj   +1 more source

Splice_sim: a nucleotide conversion-enabled RNA-seq simulation and evaluation framework

Genome Biology
Nucleotide conversion RNA sequencing techniques interrogate chemical RNA modifications in cellular transcripts, resulting in mismatch-containing reads. Biases in mapping the resulting reads to reference genomes remain poorly understood.
Niko Popitsch, Tobias Neumann, Arndt von Haeseler, Stefan L. Ameres   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source