Results 51 to 60 of about 1,708,901 (308)

Mapping Conformational Heterogeneity of Mitochondrial Nucleotide Transporter in Uninhibited States [PDF]

Angewandte Chemie, 2015
AbstractOne of the less well understood aspects of membrane transporters is the dynamic coupling between conformational change and substrate transport. NMR approaches are used herein to investigate conformational heterogeneity of the GTP/GDP carrier (GGC) from yeast mitochondria.
Sounier, Rémy, Bellot, Gaëtan, Chou, J. J.   +2 more
openaire   +2 more sources

Precise and Cost-Effective Nanopore Sequencing for Post-GWAS Fine-Mapping and Causal Variant Identification

iScience, 2020
Summary: Fine-mapping of interesting loci discovered by genome-wide association study (GWAS) is mandatory to pinpoint causal variants. Traditionally, this fine-mapping is completed through increasing the genotyping density at candidate loci, for which ...
Tarek Magdy, Hui–Hsuan Kuo, Paul W. Burridge   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Identification of QTL for Plant Architecture and Flowering Performance Traits in a Multi-Environment Evaluation of a Petunia axillaris × P. exserta Recombinant Inbred Line Population

Horticulturae, 2022
Field performance of herbaceous annual plants is largely determined by plant architecture and flowering performance. A Petunia axillaris × P. exserta F7 recombinant inbred line population was grown in four field environments across the United States, and
QiuXia C. Chen, Ryan M. Warner
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Mapping complex traits with single nucleotide polymorphisms [PDF]

Nature Genetics, 1999
Molecular geneticists are developing the third generation human genome map with single nucleotide polymorphisms (SNPs), which can be assayed through chip-based microarrays. One use of these SNP markers is to locate loci that may be responsible for complex traits through linkage/linkage-disequilibrium analysis.
Lue Ping Zhao, Corinne Aragaki, Li Hsu, Filemon Quiaoit   +3 more
openaire   +1 more source

Development and diversity of Andean-derived, gene-based microsatellites for common bean (Phaseolus vulgaris L.)

BMC Plant Biology, 2009
Background Gene-based (genic) microsatellites are a useful tool for plant genetics and simple sequence repeat loci can often be found in coding regions of the genome. While EST sequencing can be used to discover genic microsatellites, direct screening of
Giraldo Martha C, Torres Monica, Blair Matthew W, Pedraza Fabio   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

DNA analyses and their applications in plant breeding

Czech Journal of Genetics and Plant Breeding, 2002
In recent years, molecular markers have been developed based on the more detailed knowledge of genome structure. Considerable emphasis has been laid on the use of molecular markers in practical breeding and genotype identification.
J. Ovesná, K. Poláková, L. Leišová
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source