Results 61 to 70 of about 280,333 (306)

A SNP based linkage map of the turkey genome reveals multiple intrachromosomal rearrangements between the Turkey and Chicken genomes [PDF]

, 2010
Background The turkey (Meleagris gallopavo) is an important agricultural species that is the second largest contributor to the world's poultry meat production.
Bastiaansen John WM, Vereijken, A., Martien AM Groenen, Aslam Muhammad L, Groenen, M.A.M., John WM Bastiaansen, Bastiaansen, J.W.M., Hendrik-Jan Megens, Muhammad L Aslam, Richard PMA Crooijmans, Addie Vereijken, Vereijken Addie, Crooijmans, R.P.M.A., Groenen Martien AM, Crooijmans Richard PMA, Megens, H.J.W.C., Aslam, M.L., Megens Hendrik-Jan   +17 more
core   +1 more source

High-throughput isolation and mapping of C. elegans mutants susceptible to pathogen infection. [PDF]

PLoS ONE, 2008
We present a novel strategy that uses high-throughput methods of isolating and mapping C. elegans mutants susceptible to pathogen infection. We show that C.
Laura E Fuhrman, Kevin V Shianna, Alejandro Aballay   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Structural variation in the chicken genome identified by paired-end next-generation DNA sequencing of reduced representation libraries [PDF]

, 2011
Background Variation within individual genomes ranges from single nucleotide polymorphisms (SNPs) to kilobase, and even megabase, sized structural variants (SVs), such as deletions, insertions, inversions, and more complex rearrangements.
Kerstens Hindrik HD, Vereijken, A., Martien AM Groenen, Bert W Dibbits, Groenen, M.A.M., Dibbits, B.W., Kerstens, H.H.D., Dibbits Bert W, Okimoto Ron, Hindrik HD Kerstens, Richard PMA Crooijmans, Addie Vereijken, Vereijken Addie, Crooijmans, R.P.M.A., Okimoto, R., Groenen Martien AM, Crooijmans Richard PMA, Ron Okimoto   +17 more
core   +1 more source

Genome-wide mapping of nucleotide excision repair with XR-seq [PDF]

Nature Protocols, 2018
Nucleotide excision repair is a versatile mechanism to repair a variety of bulky DNA adducts. We developed excision repair sequencing (XR-seq) to study nucleotide excision repair of DNA adducts in humans, mice, Arabidopsis thaliana, yeast and Escherichia coli. In this protocol, the excised oligomers, generated in the nucleotide excision repair reaction,
Jinchuan Hu, Wentao Li, Ogun Adebali, Yanyan Yang, Onur Oztas, Christopher P. Selby, Aziz Sancar   +6 more
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

High-resolution mapping of evolutionary trajectories in a phage

, 2009
Experimental evolution in rapidly reproducing viruses offers a robust means to infer substitution trajectories during evolution. But with conventional approaches, this inference is limited by how many individual genotypes can be sampled from the ...
Nekrutenko, A, Dickins, B
core   +1 more source

Precise and Cost-Effective Nanopore Sequencing for Post-GWAS Fine-Mapping and Causal Variant Identification

iScience, 2020
Summary: Fine-mapping of interesting loci discovered by genome-wide association study (GWAS) is mandatory to pinpoint causal variants. Traditionally, this fine-mapping is completed through increasing the genotyping density at candidate loci, for which ...
Tarek Magdy, Hui–Hsuan Kuo, Paul W. Burridge   +2 more
doaj   +1 more source

A Robust and Rapid Candidate Gene Mapping Pipeline Based on M2 Populations

Frontiers in Plant Science, 2021
The whole-genome sequencing-based bulked segregant analysis (WGS-BSA) has facilitated the mapping candidate causal variations for cloning target plant genes.
Huangkai Zhou, Huangkai Zhou, Kuanqiang Tang, Kuanqiang Tang, Guang Li, Guang Li, Wenqiang Liu, Hui Yu, Xiaohui Yuan, Suxin Yang, Madan K. Bhattacharyya, Xianzhong Feng   +11 more
doaj   +1 more source

Mapping Conformational Heterogeneity of Mitochondrial Nucleotide Transporter in Uninhibited States [PDF]

Angewandte Chemie, 2015
AbstractOne of the less well understood aspects of membrane transporters is the dynamic coupling between conformational change and substrate transport. NMR approaches are used herein to investigate conformational heterogeneity of the GTP/GDP carrier (GGC) from yeast mitochondria.
Sounier, Rémy, Bellot, Gaëtan, Chou, J. J.   +2 more
openaire   +2 more sources