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Ligand-free palladium-catalyzed synthesis of 3-(2,2-dialkyl-2H-chromen-4-yl)-2-phenylimidazo[1,2-a]pyridine derivatives: molecular docking investigation of their potential as DNA gyrase inhibitors and evaluation of their antibacterial activities. [PDF]
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Pharmacology & Therapeutics, 1989
Since the action of the two major classes of gyrase inhibitor, the coumarins and the quinolones, differ mechanistically, their primary physiological effects are described separately. These discussions include aspects of inhibition of eukaryotic topoisomerases to facilitate a comparison of prokaryotic and eukaryotic organisms. We then address the repair
K, Drlica, S, Coughlin
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Since the action of the two major classes of gyrase inhibitor, the coumarins and the quinolones, differ mechanistically, their primary physiological effects are described separately. These discussions include aspects of inhibition of eukaryotic topoisomerases to facilitate a comparison of prokaryotic and eukaryotic organisms. We then address the repair
K, Drlica, S, Coughlin
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Expert Opinion on Therapeutic Targets, 2001
The discovery of the peptide DNA gyrase inhibitor microcin B17 (MccB17) in the early 1990s provided a new tool and hope for a novel peptide-based chemical starting point for a new generation of DNA gyrase inhibitors but the definitive mechanism-of-action of MccB17 has remained unknown.
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The discovery of the peptide DNA gyrase inhibitor microcin B17 (MccB17) in the early 1990s provided a new tool and hope for a novel peptide-based chemical starting point for a new generation of DNA gyrase inhibitors but the definitive mechanism-of-action of MccB17 has remained unknown.
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DNA Gyrase: Structure and Function
Critical Reviews in Biochemistry and Molecular Biology, 1991DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA.
R J, Reece, A, Maxwell
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Advances in DNA gyrase inhibitors
Expert Opinion on Investigational Drugs, 2001The therapeutic use of DNA gyrase inhibitors, mainly quinolone antibacterials, has proven to be a tremendous success story in the treatment of bacterial infections. The rapid changes in quinolone research and development in recent years have produced several new quinolones: moxifloxacin, gatifloxacin, gemifloxacin and des-6-fluoroquinolone ...
O K, Kim, K, Ohemeng, J F, Barrett
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1984
The role of DNA gyrase -a type II topoisomerase- had been speculated about for a long time before the discovery of the enzyme. In 1963, J. Cairns (1) pointed out that the Escherichia coli chromosome is a closed circular double strand DNA molecule. It has consequently become apparent that a replication machinery which has to unwind the two strands would
E, Orr, H, Lother, R, Lurz, E, Wahle
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The role of DNA gyrase -a type II topoisomerase- had been speculated about for a long time before the discovery of the enzyme. In 1963, J. Cairns (1) pointed out that the Escherichia coli chromosome is a closed circular double strand DNA molecule. It has consequently become apparent that a replication machinery which has to unwind the two strands would
E, Orr, H, Lother, R, Lurz, E, Wahle
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DNA supercoiling by DNA gyrase
Cell Biophysics, 1988Using purified DNA gyrase to supercoil circular plasmid pBR322 DNA, we examined how the linking number attained at the steady state ('static head') varies with the concentrations of ATP and ADP, both in the absence and presence of spermidine. In the absence of spermidine at total adenine nucleotide concentrations between 0.35 and 1.4 mM, the static ...
H V, Westerhoff +3 more
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