Results 91 to 100 of about 350,926 (202)

The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F

mSphere, 2016
The human adenovirus E4orf6/E1B55K E3 ubiquitin ligase is well known to promote viral replication by degrading an increasing number of cellular proteins that inhibit the efficient production of viral progeny.
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette   +5 more
doaj   +1 more source

TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING.

PLoS Pathogens, 2015
Uncontrolled immune responses to intracellular DNA have been shown to induce autoimmune diseases. Homeostasis regulation of immune responses to cytosolic DNA is critical for limiting the risk of autoimmunity and survival of the host. Here, we report that
Yanming Wang, Qiaoshi Lian, Bo Yang, Shanshan Yan, Haiyan Zhou, Lan He, Guomei Lin, Zhexiong Lian, Zhengfan Jiang, Bing Sun   +9 more
doaj   +1 more source

Urine Specimens from Pregnant and Nonpregnant Women Inhibitory to Amplification of \u3cem\u3eChlamydia trachomatis\u3c/em\u3e Nucleic Acid by PCR, Ligase Chain Reaction, and Transcription-Mediated Amplification: Identification of Urinary Substances Associated with Inhibition and Removal of Inhibitory Activity [PDF]

, 1998
The presence of endogenous amplification inhibitors in urine may produce false-negative results for the detection of Chlamydia trachomatis nucleic acids by tests such as PCR, ligase chain reaction (LCR), and transcription-mediated amplification (TMA ...
Chernesky, Max A., Chong, Sylvia, Faught, M., Guthrie, Dawn M., Jang, Dan, Luinstra, Kathy, Mahoney, James, Sellors, John W.   +7 more
core   +1 more source

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. [PDF]

, 2019
Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR).
Peschek, Jirka, Walter, Peter
core  

Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences [PDF]

, 2017
‘Classical' non-homologous end joining (NHEJ), dependent on the Ku70/80 and the DNA ligase IV/XRCC4 complexes, is essential for the repair of DNA double-strand breaks. Eukaryotic cells possess also an alternative microhomology-mediated end-joining (MMEJ)
Crespan, Emmanuele, Czabany, Tibor, Hübscher, Ulrich, Maga, Giovanni   +3 more
core  

A Commentary on Mitochondrial Dysfunction and Compromised DNA Repair in Neurodegeneration: The Emerging Role of FUS in ALS

Neuroscience Insights
Mitochondrial dysfunction plays a pivotal role in the progression of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, and Parkinson’s disease.
Manohar Kodavati, Muralidhar L Hegde
doaj   +1 more source

The Association of DNA Ligase 1 Rs20579 Polymorphism With Lung Cancer Risk Among Taiwanese. [PDF]

In Vivo, 2023
Chang SM, Yang YC, Chen GL, Chen LH, Shen TC, Liu YF, Wang YC, Tsai CW, Hsia TC, Bau DT, Chang WS.   +10 more
europepmc   +1 more source

Profiling DNA Ligase Substrate Specificity with a Pacific Biosciences Single-Molecule Real-Time Sequencing Assay. [PDF]

Curr Protoc, 2023
Duckworth AT, Bilotti K, Potapov V, Lohman GJS.   +3 more
europepmc   +1 more source

Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin. [PDF]

J Transl Med, 2022
Caracciolo D, Juli G, Riillo C, Coricello A, Vasile F, Pollastri S, Rocca R, Scionti F, Polerà N, Grillone K, Arbitrio M, Staropoli N, Caparello B, Britti D, Loprete G, Costa G, Di Martino MT, Alcaro S, Tagliaferri P, Tassone P.   +19 more
europepmc   +1 more source

The Deletion of the Bre1 Gene in Aspergillus nidulans Impairs Mitotic Growth, Meiosis, and DNA Damage Repair

, 2013
Bre1 is a homotetrameric E3 ubiquitin-protein ligase that heterodimerizes with Rad6, an E2 ubiquitin-conjugating enzyme, in order to ubiquitinate lysine 123 in Aspergillus nidulans.
James, Steven W., Sitton, Andrea J.
core