Results 191 to 200 of about 2,416,649 (374)

DNA Ligase 4 Contributes to Cell Proliferation against DNA-PK Inhibition in MYCN-Amplified Neuroblastoma IMR32 Cells. [PDF]

Int J Mol Sci, 2023
Ando K, Suenaga Y, Kamijo T.
europepmc   +1 more source

Purification and characterization of DNA ligase III from bovine testes. Homology with DNA ligase II and vaccinia DNA ligase.

The Journal of biological chemistry, 1995
Mammalian cell nuclei contain three biochemically distinct DNA ligases. In the present study we have found high levels of DNA ligase I and DNA ligase III activity in bovine testes and have purified DNA ligase III to near homogeneity. The high level of DNA ligase III suggests a role for this enzyme in meiotic recombination.
I, Husain, A E, Tomkinson, W A, Burkhart, M B, Moyer, W, Ramos, Z B, Mackey, J M, Besterman, J, Chen   +7 more
openaire   +1 more source

Ligation Protocol with T4 DNA Ligase (M0202) v3 [PDF]

, 2020
New England Biolabs
openalex   +1 more source

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Catalytically inactive DNA ligase IV promotes DNA repair in living cells. [PDF]

Nucleic Acids Res, 2022
Goff NJ, Brenière M, Buehl CJ, de Melo AJ, Huskova H, Ochi T, Blundell TL, Mao W, Yu K, Modesti M, Meek K.   +10 more
europepmc   +1 more source

SV2B Promotes the Progression of TFE3‐Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF‐κB Subunits

Advanced Science, EarlyView.
TFE3‐rearranged renal cell carcinoma (TFE3‐RCC) lacks clearly defined diagnostic and therapeutic targets. SV2B, a TFE3 target gene, promotes TFE3‐RCC progression by activating the NF‐κB pathway. Targeted inhibition with padsevonil or Withaferin A effectively suppresses tumor progression.
Huayi Feng, Zhuang Xiong, Shaoqing Yu, Junxiao Liu, Shouqing Cao, Kan Liu, Xing Huang, Lequan Wen, Baojun Wang, Qingbo Huang, Tiejun Pan, Xu Zhang, Xin Ma, Xiubin Li   +13 more
wiley   +1 more source

Structure/function studies of the NAD⁺-dependent DNA ligase from the poly-extremophile Deinococcus radiodurans reveal importance of the BRCT domain for DNA binding. [PDF]

Extremophiles, 2023
Fernandes A, Williamson A, Matias PM, Moe E.   +3 more
europepmc   +1 more source

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Molecules and Cells, 2017
Laure Ferry, A. Fournier, Takeshi Tsusaka, G. Adelmant, Tadahiro Shimazu, Shohei Matano, Olivier Kirsh, R. Amouroux, N. Dohmae, Takehiro Suzuki, Guillaume J. Filion, Wen Deng, Maud de Dieuleveult, L. Fritsch, Srikanth Kudithipudi, A. Jeltsch, H. Leonhardt, P. Hájková, J. Marto, K. Arita, Y. Shinkai, P. Defossez   +21 more
semanticscholar   +1 more source

Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence [PDF]

Jack B. Roberts, Olivia Lucy Georgina Boldvig, Guillaume Aubourg, Sai Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice, John Loughlin   +6 more
openalex   +1 more source

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

Advanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang, Huanhuan Huang, Kaizong Huang, Xiaowen Cui, Leilei Wu, Renyu Lin, Zhe Zhao, Hua Chen, Cheng Zheng, Weilin Jin, Song Chen, Jiayan Chen, Yaping Xu, Dongping Wei   +13 more
wiley   +1 more source