Results 171 to 180 of about 3,407,466 (313)

Correction: The application of DNA markers in population genetics of mosquitoes: a comprehensive review. [PDF]

Front Insect Sci
Frontiers Production Office.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The current state of the use of DNA markers for improving the efficiency of rice breeding in Japan. [PDF]

Breed Sci
Goto A, Matsushita K, Yamanouchi U.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Comparative plastid genomics of Hippophae reveals phylogenetic relationships and provides candidate DNA markers for taxonomic identification. [PDF]

Sci Rep
Asakura N, Noda M, Takahashi Y, Ueno S, Arai N.   +4 more
europepmc   +1 more source

Cloning, sequencing, and characterizing of soil antibiotic active-producing <i>Streptomyces</i> species-specific DNA markers. [PDF]

Saudi J Biol Sci, 2023
Saadoun I, Mahasneh A, Odat JD, Al-Joubori B, Elsheikh E.   +4 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Plasma assay of methylated DNA markers detects recurrent metastatic breast cancer. [PDF]

NPJ Breast Cancer
Giridhar KV, Sinnwell JP, Slettedahl SW, Taylor WR, Mahoney DW, Foote PH, O'Connell MC, Robran MJ, Devens ME, Gonser AM, Larson NL, Doering KA, Burger KN, Kaiser MW, Allawi HT, Ruddy KJ, Olson JE, Couch FJ, Kisiel JB.   +18 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Plasma cell-free DNA markers predict occult metastases in patients with resectable pancreatic ductal adenocarcinoma. [PDF]

Clin Transl Med
Till JE, Gal-Rosenberg O, Giliberto SG, Seewald NJ, Ballinger DG, Samberg HE, Yin MR, Wang QL, Cannas S, Kim KN, Tien K, Sawi M, Madineedi V, Furniss CS, Gocheva V, Nowak J, Brais LK, Yuan C, Rosenthal MH, Roses R, DeMatteo R, Lee MK, Vollmer C, Sagreiya H, O'Hara MH, Shemer R, Wolpin B, Dor Y, Carpenter EL.   +28 more
europepmc   +1 more source