Results 351 to 360 of about 5,610,569 (399)

DNA adducts as markers of exposure and risk

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
Many carcinogens exert their biological effects through the formation of DNA adducts by metabolically activated intermediates. Detecting the presence of DNA adducts in human tissues is, therefore, a tool for molecular epidemiological studies of cancer.
Phillips, David H, Phillips, David
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DNA-and classical genetic markers in schizophrenia

European Archives of Psychiatry and Clinical Neuroscience, 1991
Interest in genetic marker studies of schizophrenia has been considerably enhanced by the advent of recombinant DNA technology, which has dramatically increased the number of available markers. In the present paper, we review studies that have been carried out using classical markers as well as the more recent molecular studies. The problems that arise
M J, Owen, P, McGuffin
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DNA Markers for Nervous System Diseases

Science, 1984
Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders.
J F, Gusella, R E, Tanzi, M A, Anderson, W, Hobbs, K, Gibbons, R, Raschtchian, T C, Gilliam, M R, Wallace, N S, Wexler, P M, Conneally   +9 more
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DNA Methylation As a Clinical Marker in Oncology

Journal of Clinical Oncology, 2012
Personalized oncology is critically dependent on accurate measurement of biomarkers in cancer tissues or surrogate tissues if appropriate. Historically, the field started with protein biomarkers such as hormonal status in breast cancer and genetic biomarkers such as chromosomal changes in the management of patients with acute myeloid leukemia.
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DNA markers for the diagnosis of Wilson disease

Journal of Hepatology, 1993
Wilson disease is an autosomal recessive disorder of copper transport for which the basic defect is unknown. Laboratory diagnosis of Wilson disease is usually made by measuring serum ceruloplasmin concentration, urinary copper excretion, and liver copper concentration.
R H, Houwen, E A, Roberts, G R, Thomas, D W, Cox   +3 more
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DNA methylation as a marker for the past and future

Journal of Gastroenterology, 2006
Aberrant methylation of CpG islands in promoter regions can permanently inactivate tumor-suppressor genes, as mutations and chromosomal abnormalities do. In gastric cancers, CDKN2A, CDH1, and MLH1 are inactivated more frequently by aberrant methylation than by mutations, and novel tumor-suppressor genes inactivated by promoter methylation are being ...
Toshikazu, Ushijima, Takeshi, Nakajima, Takao, Maekita   +2 more
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Microsatellite DNA markers for rice chromosomes

TAG Theoretical and Applied Genetics, 1996
We found 369 complete microsatellites, of which (CGG/GCC)n was the most frequent, in 11 798 rice sequences in the database. Of these microsatellites, 35 out of 45 could be successfully converted into microsatellite DNA markers using sequence information in their flanking regions.
H, Akagi, Y, Yokozeki, A, Inagaki, T, Fujimura   +3 more
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AFLP™ markers for DNA fingerprinting in cattle

Animal Genetics, 1997
This work reports on use of the recently described amplified fragment length polymorphism (AFLP) technology for DNA fingerprinting in cattle. The AFLP technology produces molecular markers through the high‐stringency polymerase chain reaction (PCR)‐amplification of restriction fragments that are ligated to synthetic adapters and amplified using primers,
AJMONE MARSAN P, VALENTINI A, CASSANDRO, MARTINO, VECCHIOTTI ANTALDI G, BERTONI G, KUIPER M.   +5 more
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Classical genetic markers and DNA markers: A commensal marriage

Primates, 1993
In this paper, we present an overview of classical genetic markers in nonhuman primates and then contrast the discriminatory powers of these markers with DNA markers. We have restricted the scope of our discussion to genetic markers found in blood, since they have been studied most extensively over the past 30 years.
W. H. Stone, J. J. Ely, G. S. Manis, J. L. VandeBerg   +3 more
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Comparison of different nuclear DNA markers for estimating intraspecific genetic diversity in plants

Molecular Ecology, 2004
H. Nybom
semanticscholar   +1 more source