Results 71 to 80 of about 5,610,569 (399)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Molecular and Population Genetics Tools for Farm Animal Genetic Resources Conservation: Brief Overview

Scientific Papers Animal Science and Biotechnologies, 2023
Advances in animal genome data and in genetic analysis, next to the increasing use of artificial reproductive technology resulted in progress into the animal sciences area, transposing the applied technologies into the omics field.
Claudia Terezia Socol, Lelior Iacob, Ioan Mihalca, Florin Leontin Criste   +3 more
doaj  

Concentration and Methylation of Cell-Free DNA from Blood Plasma as Diagnostic Markers of Renal Cancer

Disease Markers, 2016
The critical point for successful treatment of cancer is diagnosis at early stages of tumor development. Cancer cell-specific methylated DNA has been found in the blood of cancer patients, indicating that cell-free DNA (cfDNA) circulating in the blood is
I. Skrypkina, L. Tsyba, K. Onyshchenko, D. Morderer, O. Kashparova, O. Nikolaienko, G. Panasenko, S. Vozianov, A. Romanenko, A. Rynditch   +9 more
semanticscholar   +1 more source

Basic concepts and methodologies of DNA marker systems in plant molecular breeding

Heliyon, 2021
The concepts, methodologies and applications of some of the major molecular or DNA markers commonly used in plant science have been presented. The general principles of molecular marker techniques have been elucidated with detailed explanation of some ...
S. Amiteye
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evaluation of the budbreak timing in walnut cultivars and breeding forms among the Kuban germplasm, and validation of the trait-related SSR-markers

Труды по прикладной ботанике, генетике и селекции
Background. Walnut (Juglans regia L.) is the most widespread species within the genus Juglans. Late spring frosts can significantly reduce its yield.
I. I. Suprun, E. A. Al-Nakib, I. V. Stepanov, E. V. Lobodina, S. N. Shcheglov   +4 more
doaj   +1 more source

Application of DNA markers in molecular breeding and genetic studies of grapevine

Вавиловский журнал генетики и селекции, 2016
DNA technology has increasingly become more and more important over last years. They can be used to improve the breeding of agricultural plants. Grapevine is one of the oldest and most important cultured plants.
E. T. Ilnitskaya, M. V. Makarkina
doaj   +1 more source

Population biobank as a basis for determining spatial variation of clinically relevant pharmacogenetic biomarkers of cardiovascular diseases

Кардиоваскулярная терапия и профилактика, 2022
The introduction of pharmacogenetic tests among the Russian population faces a fundamental limitation  — pronounced genetic differences between populations.
V. Yu. Pylev, A. T. Agdzhoyan, I. O. Gorin, V. S. Petrushenko, E. A. Pocheshkhova, K. B. Mirzaev, E. V. Balanovskaya   +6 more
doaj   +1 more source

SNP Assay Development for Linkage Map Construction, Anchoring Whole-Genome Sequence, and Other Genetic and Genomic Applications in Common Bean. [PDF]

, 2015
A total of 992,682 single-nucleotide polymorphisms (SNPs) was identified as ideal for Illumina Infinium II BeadChip design after sequencing a diverse set of 17 common bean (Phaseolus vulgaris L) varieties with the aid of next-generation sequencing ...
Cregan, Perry B, Hwang, Eun-Young, Hyten, David L, Jackson, Scott A, Jenkins, Jerry, Jia, Gaofeng, McClean, Phillip E, Osorno, Juan M, Schmutz, Jeremy, Schroeder, Steven G, Song, Qijian   +10 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source