Results 101 to 110 of about 1,977,316 (301)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. [PDF]

, 2012
The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD).
Eisenmenger, Wolfgang, Bondy, Brigitta, Mazza, Marianna, Zill, Peter, Clemens Früstück, Brigitta Bondy, Büttner, Andreas, Born, Christoph, Peter Zill, Andreas Büttner, Varallo-Bedarida, Gabriella, Cornelius Schüle, Früstück, Clemens, Rupprecht, Rainer, Möller, Hans-Jürgen, Schüle, Cornelius, Baghai, Thomas C., Wolfgang Eisenmenger, Christoph Born, Rainer Rupprecht, Hans-Jürgen Möller, Thomas C Baghai, Gabriella Varallo-Bedarida, Varallo-Bedarida Gabriella, Baghai Thomas C., Schüle Cornelius, Eisenmenger Wolfgang, Früstück Clemens, Bondy Brigitta, Born Christoph, Büttner Andreas, Rupprecht Rainer, Zill Peter, Möller Hans-Jürgen   +33 more
core   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Patients improve, patterns persist: longitudinal stability of RA joint involvement patterns

Arthritis Care &Research, Accepted Article.
Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen, Yasuo Nagafuchi, Kristina Lend, Seyam Alemyar, Herman Kasper Glas, Gerdur Gröndal, Bjorn Gudbjornsson, Espen A. Haavardsholm, Kim Hørslev Petersen, Jon Lampa, Merete Lund Hetland, Dan Nordström, Mike Nurmohamed, Mikkel Østergaard, Anna Rudin, Marte Schrumpf Heiberg, Tuulikki Sokka‐Isler, Till Uhlig, Josien Veris‐van Dieren, Ronald van Vollenhoven, Tom Huizinga, Marcel JT Reinders, Sytske Anne Bergstra, Erik van den Akker, Rachel Knevel   +24 more
wiley   +1 more source

CpG-methylation regulates a class of Epstein-Barr virus promoters. [PDF]

, 2010
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian gene regulation. In general, cytosine-phosphatidyl-guanosine (CpG)-methylated promoters are transcriptionally repressed and nuclear proteins such as ...
Benet-Pagès, Anna, Christine Göbel, Göbel, C., Hammerschmidt, W., Wolfgang Hammerschmidt, Schmeinck Anne, Benet-Pagès Anna, Bergbauer Martin, Schmeinck, A., Eck Sebastian, Rothbauer, Ulrich, Strom, Tim M., Hammerschmidt, Wolfgang, Bergbauer, M., Kalla, M., Sebastian Eck, Rothbauer, U., Schmeinck, Anne, Bergbauer, Martin, Göbel Christine, Tim M. Strom, Göbel, Christine, Tim M Strom, Strom Tim M., Eck, Sebastian, Anne Schmeinck, Eck, S., Martin Bergbauer, Benet-Pagès, A., Kalla, Markus, Hammerschmidt Wolfgang, Rothbauer Ulrich, Strom, T.M., Markus Kalla, Ulrich Rothbauer, Kalla Markus, Anna Benet-Pagès   +36 more
core   +2 more sources

Versatile molecular tools enabling customizable DNA methylation editing in Arabidopsis

Nature Communications
Tools to edit DNA methylation in a targeted manner are vital for establishing causal relationships between DNA methylation and its function, as well as for plant breeding and gene therapy.
Li He, Yao Yao, Yin You, Xiaofei Wei, Yu Ma, Wei Yuan, Zhaobo Lang, Jian-Kang Zhu   +7 more
doaj   +1 more source

Comparative analysis of genome-wide DNA methylation in Neurospora

Epigenetics, 2020
DNA methylation is an epigenetic mark that plays an important role in genetic regulation in eukaryotes. Major progress has been made in dissecting the molecular pathways that regulate DNA methylation.
Sara Hosseini, Cécile Meunier, Diem Nguyen, Johan Reimegård, Hanna Johannesson   +4 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. [PDF]

, 2013
BACKGROUND: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have
Dominguez Salas, Paula, Dyer, Roger A, Andrew M Prentice, Waterland, Robert A., Kerry-Ann da Costa, Cole, Darren, Zeisel, Steven H., Prentice, Andrew M, Hennig, Branwen J, Paula Dominguez-Salas, Sophie E Moore, Moore, Sophie E, Zeisel, Steven H, Anthony JC Fulford, Moore, Sophie E., Robert A Waterland, Darren Cole, Fulford, Anthony JC, Branwen J Hennig, Dyer, Roger A., Fulford, Anthony J.C., Sharon E Cox, Sheila M Innis, Steven H Zeisel, Dominguez-Salas, Paula, Innis, Sheila M, da Costa, Kerry-Ann, Roger A Dyer, Waterland, Robert A, Innis, Sheila M., Cox, Sharon E, Prentice, Andrew M., Da Costa, Kerry Ann, Hennig, Branwen J., Cox, Sharon E.   +34 more
core   +1 more source

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Advanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte   +8 more
wiley   +1 more source