Results 151 to 160 of about 1,977,316 (301)

Author Correction: DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development. [PDF]

Nat Commun
He L, Huang H, Bradai M, Zhao C, You Y, Ma J, Zhao L, Lozano-Durán R, Zhu JK.   +8 more
europepmc   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Blood DNA methylation profile is altered in severe bronchiectasis. [PDF]

ERJ Open Res
Perea L, Viglino J, Solarat B, Marrades P, Casas-Recasens S, Mendoza N, Martínez-Olondris P, Amaro R, Agustí A, Shoemark A, Aliberti S, Chalmers JD, Sibila O, Faner R.   +13 more
europepmc   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

DNA Methylation-Mediated Regulation of Plant Adaptation to Abiotic Stress. [PDF]

Plants (Basel)
Liu G, Wang H, Tang Y, Gao H, Wang Y, Sun Y, Yu S, Zhang D, Jiang Z.   +8 more
europepmc   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

DNA methylation-based classification of hematolymphoid neoplasms. [PDF]

Blood Adv
Saksena A, Siewert C, Turakulov R, Singh O, Abdullaev Z, Zhou T, Karrs J, Alves De Castro JV, Riley D, Skarshaug S, Zgonc V, Sultanaeva L, Teng R, Xi L, Kreitman RJ, von Deimling A, Duran-Ferrer M, Martín-Subero JI, Campo E, Englert B, Richter J, Klapper W, Anagnostopoulos I, Rosenwald A, Wobser M, Fend F, Quintanilla-Martinez L, Ferrer G, Esteller M, Piris MA, Hummel M, Pittaluga S, Raffeld M, Jaffe ES, Capper D, Aldape K.   +35 more
europepmc   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

DNA methylation biomarkers for early detection of ovarian cancer. [PDF]

Mol Biol Rep
Leow JY, Ng NC, Wong RS, Ming LC, Yap TL, Goh BH.   +5 more
europepmc   +1 more source