Results 11 to 20 of about 2,392,207 (383)
Sarcoma classification by DNA methylation profiling
Nature Communications, 2021 Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features.
C. Koelsche +110 more
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Genetic and DNA methylation changes in cotton (Gossypium) genotypes and tissues. [PDF]
PLoS ONE, 2014 In plants, epigenetic regulation is important in normal development and in modulating some agronomic traits. The potential contribution of DNA methylation mediated gene regulation to phenotypic diversity and development in cotton was investigated between
Kenji Osabe +7 more
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Aging and DNA methylation [PDF]
BMC Biology, 2015 In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is ...
Marc Jung, Gerd P. Pfeifer
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DNA methylation in insects [PDF]
Insect Molecular Biology, 2004 AbstractCytosine DNA methylation has been demonstrated in numerous eukaryotic organisms and has been shown to play an important role in human disease. The function of DNA methylation has been studied extensively in vertebrates, but establishing its primary role has proved difficult and controversial.
Field, L. M. +3 more
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
Nature, 2008 Alexander Meissner +2 more
exaly +2 more sources
Cell Stem Cell, 2011 How DNA methyltransferases, with their limited target specificity, establish cell-type-specific epigenetic patterns is poorly understood. Schübeler and colleagues (Lienert et al., 2011) now show that methylation-determining regions (MDRs) within promoter regions are sufficient to recapitulate endogenous patterns and dynamics of DNA methylation.
Alexander Meissner, Alexander Meissner
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Influence of genetic background and tissue types on global DNA methylation patterns. [PDF]
PLoS ONE, 2010 Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However, the effects of genetic background and tissue types on DNA methylation at the genome-wide level have not been characterized extensively ...
Howard H Yang +7 more
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DNA methylation heterogeneity induced by collaborations between enhancers [PDF]
Journal of Computational Biology, 2020, 2020 During mammalian embryo development, reprogramming of DNA methylation plays important roles in the erasure of parental epigenetic memory and the establishment of na\"{i}ve pluripogent cells. Multiple enzymes that regulate the processes of methylation and demethylation work together to shape the pattern of genome-scale DNA methylation and guid the ...
arxiv +1 more source
Methylated DNA Immunoprecipitation [PDF]
Journal of Visualized Experiments, 2009 The identification of DNA methylation patterns is a common procedure in the study of epigenetics, as methylation is known to have significant effects on gene expression, and is involved with normal development as well as disease. Thus, the ability to discriminate between methylated DNA and non-methylated DNA is essential for generating methylation ...
Carolyn J. Brown +10 more
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Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells. [PDF]
PLoS ONE, 2010 Global loss of DNA methylation and locus/gene-specific gain of DNA methylation are two distinct hallmarks of carcinogenesis. Aberrant DNA methylation is implicated in smoking-related lung cancer.
Stella Tommasi +5 more
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