Results 361 to 370 of about 2,729,754 (384)
Some of the next articles are maybe not open access.
Critical Reviews in Biochemistry, 1982
The DNA of higher eukaryotes contains one minor base, namely 5-methylcytosine. The distribution of this minor base between different species and different DNA fractions will be considered together with the actual sequences methylated. The properties of the enzyme responsible for DNA modification will be reviewed, particular note being paid to the ...
R. L. P. Adams +2 more
openaire +3 more sources
The DNA of higher eukaryotes contains one minor base, namely 5-methylcytosine. The distribution of this minor base between different species and different DNA fractions will be considered together with the actual sequences methylated. The properties of the enzyme responsible for DNA modification will be reviewed, particular note being paid to the ...
R. L. P. Adams +2 more
openaire +3 more sources
Immunoprecipitation of Methylated DNA
2009DNA methylation contributes to the regulation of long-term gene repression by enabling the recruitment of transcriptional repressor complexes to methylated cytosines. Several methods for detecting DNA methylation at the gene-specific and genome-wide levels have been developed.
Anita L. Sørensen, Philippe Collas
openaire +3 more sources
Human Molecular Genetics, 1994
Changes in the pattern of DNA methylation have been a consistent finding in cancer cells. The mostly descriptive nature of these studies and the fact that both hypo- and hypermethylation have been observed at various loci have made it difficult to assess whether these changes are causally involved in the transformation process or whether they reflect ...
Peter W. Laird, Rudolf Jaenisch
openaire +3 more sources
Changes in the pattern of DNA methylation have been a consistent finding in cancer cells. The mostly descriptive nature of these studies and the fact that both hypo- and hypermethylation have been observed at various loci have made it difficult to assess whether these changes are causally involved in the transformation process or whether they reflect ...
Peter W. Laird, Rudolf Jaenisch
openaire +3 more sources
DNA methylation-based predictors of health: applications and statistical considerations
Nature reviews genetics, 2022P. Yousefi +5 more
semanticscholar +1 more source
Methyl DNA Immunoprecipitation
2009Epigenetics is the study of heritable changes in gene expression. Chromatin immunoprecipitation (ChIP) and methylation status analysis of genes have been applied to the study of epigenetic modifications, often perturbed in human cancer. ChIP is a technique allowing the analysis of the protein association with specific genomic regions in the context of ...
Jean-Jacques Goval, Juana Magdalena
openaire +3 more sources
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Nature reviews genetics, 2012Peter A. Jones
semanticscholar +1 more source
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Nature reviews genetics, 2018S. Horvath, K. Raj
semanticscholar +1 more source
Annals of the New York Academy of Sciences, 2004
Abstract: Early detection of cancer would facilitate better management of patients, because survival is greatly affected by stage of presentation. Circulating nucleic acids represent a biomarker that might be used in the early detection of cancer. In addition, such biomarkers could potentially be used to follow the progression of patients with cancer.
openaire +3 more sources
Abstract: Early detection of cancer would facilitate better management of patients, because survival is greatly affected by stage of presentation. Circulating nucleic acids represent a biomarker that might be used in the early detection of cancer. In addition, such biomarkers could potentially be used to follow the progression of patients with cancer.
openaire +3 more sources
2010
DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene expression and facilitate chromatin organization within cells. Aberrant DNA methylation patterns are acquired during carcinogenic transformation; such events are often accompanied by alterations in chromatin structure at gene regulatory regions.
Phillippa C. Taberlay, Peter A. Jones
openaire +3 more sources
DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene expression and facilitate chromatin organization within cells. Aberrant DNA methylation patterns are acquired during carcinogenic transformation; such events are often accompanied by alterations in chromatin structure at gene regulatory regions.
Phillippa C. Taberlay, Peter A. Jones
openaire +3 more sources
The diverse roles of DNA methylation in mammalian development and disease
Nature reviews. Molecular cell biology, 2019Maxim V. C. Greenberg, D. Bourc’his
semanticscholar +1 more source