Results 121 to 130 of about 2,560,073 (378)

Comparison of mRNA gene expression by RT-PCR and DNA microarray

BioTechniques, 2004
Few studies have compared the quantification of mRNA by DNA microarray to the results obtained by reverse transcription PCR (RT-PCR). In this study, mRNA was collected from the healing femoral fracture callus of adult and juvenile rats at various times ...
Wiguins Etienne, Martha H. Meyer, Johnny Peppers, Ralph A. Meyer   +3 more
doaj   +1 more source

FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data

BMC Bioinformatics, 2007
BackgroundData clustering analysis has been extensively applied to extract information from gene expression profiles obtained with DNA microarrays. To this aim, existing clustering approaches, mainly developed in computer science, have been adapted to ...
L. Fu, E. Medico
semanticscholar   +1 more source

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

Advanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu, Xiumei Zhao, Maolin Zang, Huiyang Yuan, Xin Qin, Xiaofeng Li, Shuo Zhao, Ruirong Tan, Keqiang Yan, Li Liu, Yidong Fan, Ning Zhang, Benkang Shi, Bo Han, Shouzhen Chen   +14 more
wiley   +1 more source

A new non-linear normalization method for reducing variability in DNA microarray experiments

Genome Biology, 2002
BackgroundMicroarray data are subject to multiple sources of variation, of which biological sources are of interest whereas most others are only confounding.
C. Workman, L. Jensen, H. Jarmer, R. Berka, L. Gautier, H. B. Nielser, H. Saxild, Claus Nielsen, S. Brunak, S. Knudsen   +9 more
semanticscholar   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Fast and Economic Microarray-Based Detection of Species-, Resistance-, and Virulence-Associated Genes in Clinical Strains of Vancomycin-Resistant Enterococci (VRE)

Sensors
Today, there is a continuous worldwide battle against antimicrobial resistance (AMR) and that includes vancomycin-resistant enterococci (VRE). Methods that can adequately and quickly detect transmission chains in outbreaks are needed to trace and manage ...
Ibukun Elizabeth Osadare, Stefan Monecke, Abdinasir Abdilahi, Elke Müller, Maximilian Collatz, Sascha Braun, Annett Reissig, Wulf Schneider-Brachert, Bärbel Kieninger, Anja Eichner, Anca Rath, Jürgen Fritsch, Dominik Gary, Katrin Frankenfeld, Thomas Wellhöfer, Ralf Ehricht   +15 more
doaj   +1 more source

Defining signal thresholds in DNA microarrays: exemplary application for invasive cancer

BMC Genomics, 2002
Background Genome-wide or application-targeted microarrays containing a subset of genes of interest have become widely used as a research tool with the prospect of diagnostic application.
Head S, Buehler LK, Bilban M, Desoye G, Quaranta V   +4 more
doaj   +1 more source

Genome-wide maps of DNA-protein interactions using a yeast ORF and intergenic microarray [PDF]

, 1999
Vishwanath R. Iyer, Christine E. Horak, Laurent Kuras, Péter Kósa, Charles Scafe, David Botstein, Kevin Struhl, M Snyder, Patrick O. Brown   +8 more
openalex   +1 more source

Transcriptional control of the H-NS antagonists LeuO and RcsB-BglJ in Escherichia coli [PDF]

, 2012
The bacterial nucleoid-associated protein (NAP) H-NS is involved in the organization and compaction of the bacterial chromatin and acts as a global respressor, mainly of genes that have been acquired by horizontal gene transfer and that are related to ...
Stratmann, Thomas
core  

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source