Results 121 to 130 of about 410,424 (355)
Defining signal thresholds in DNA microarrays: exemplary application for invasive cancer
BMC Genomics, 2002 Background Genome-wide or application-targeted microarrays containing a subset of genes of interest have become widely used as a research tool with the prospect of diagnostic application.
Head S +4 more
doaj +1 more source
Hybridization to surface-bound oligonucleotide probes: Influence of point defects [PDF]
arXiv, 2006 Microarray-based genotyping is based on the high discrimination capability of oligonucleotide probes. For detection of Single Nucleotide Polymorphisms (SNPs) single-base discrimination is required. We investigate how various point-mutations, comprising single base mismatches (MMs), insertions and deletions, affect hybridization of DNA-DNA ...
arxiv
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization
Advanced Science, EarlyView.This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan +12 more
wiley +1 more source
Microarray analysis in the archaeon Halobacterium salinarum strain R1.
PLoS ONE, 2007 BackgroundPhototrophy of the extremely halophilic archaeon Halobacterium salinarum was explored for decades. The research was mainly focused on the expression of bacteriorhodopsin and its functional properties.
Jens Twellmeyer +8 more
doaj +1 more source
Starr: Simple Tiling Array Analysis of Affymetrix ChIP-chip data [PDF]
arXiv, 2009 Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) is an assay for DNA-protein-binding or post-translational chromatin/histone modifications. As with all high-throughput technologies, it requires a thorough bioinformatic processing of the data for which there is no standard yet.
arxiv
Genome-wide maps of DNA-protein interactions using a yeast ORF and intergenic microarray [PDF]
, 1999 Vishwanath R. Iyer +8 more
openalex +1 more source
Advanced Science, EarlyView.Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao +6 more
wiley +1 more source
Fluorescence-Based Bioassays for the Detection and Evaluation of Food Materials
Sensors, 2015 We summarize here the recent progress in fluorescence-based bioassays for the detection and evaluation of food materials by focusing on fluorescent dyes used in bioassays and applications of these assays for food safety, quality and efficacy. Fluorescent
Kentaro Nishi +3 more
doaj +1 more source
Simultaneous Qualitative And Quantitative Identification Of Multiple Targets By Polymerase Chain Reaction On Microarray [PDF]
Chapter 12 at "Oligonucleotide Array Sequence Analysis", Nova
Publishers, ISBN: 978-1-60456-542-3, 2008 An approach for multiplex qualitative and quantitative microarray-based PCR analysis has been proposed. The characteristics of PCR executed on a gel-based oligonucleotide microarray with immobilized forward primers and a single common reverse primer in solution were investigated for several DNA targets.
arxiv
Advanced Science, EarlyView.The MoSMAR‐chip platform provides a high‐throughput and cost‐effective tool for identifying and characterizing antigen‐specific antibody‐secreting cells (ASCs) and memory B cells (MBCs) at the single‐cell level. The ASCs from coronavirus disease 2019 (COVID‐19) vaccine‐immunized mice were successfully analyzed, revealing diverse neutralizing antibodies
Tian Zhao +13 more
wiley +1 more source