Results 111 to 120 of about 414,545 (349)

Defining signal thresholds in DNA microarrays: exemplary application for invasive cancer

BMC Genomics, 2002
Background Genome-wide or application-targeted microarrays containing a subset of genes of interest have become widely used as a research tool with the prospect of diagnostic application.
Head S, Buehler LK, Bilban M, Desoye G, Quaranta V   +4 more
doaj   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Microarray analysis in the archaeon Halobacterium salinarum strain R1.

PLoS ONE, 2007
BackgroundPhototrophy of the extremely halophilic archaeon Halobacterium salinarum was explored for decades. The research was mainly focused on the expression of bacteriorhodopsin and its functional properties.
Jens Twellmeyer, Andy Wende, Jan Wolfertz, Friedhelm Pfeiffer, Markus Panhuysen, Alexander Zaigler, Jörg Soppa, Gerhard Welzl, Dieter Oesterhelt   +8 more
doaj   +1 more source

DNA meets the SVD [PDF]

, 2008
This paper introduces an important area of computational cell biology where complex, publicly available genomic data is being examined by linear algebra methods, with the aim of revealing biological and medical ...
Grindrod, Peter, Higham, Desmond J., Kalna, Gabriela, Spence, Alistair, Stoyanov, Zhivko, Vass, J. Keith   +5 more
core   +1 more source

Adsorption models of hybridization and post-hybridisation behaviour on oligonucleotide microarrays

, 2006
Analysis of data from an Affymetrix Latin Square spike-in experiment indicates that measured fluorescence intensities of features on an oligonucleotide microarray are related to spike-in RNA target concentrations via a hyperbolic response function ...
Affymetrix Inc., Baxter R J, Bhanot G, Binder H, Burden C J, Cantor C R, Conrad J Burden, Deutsch J M Liang S Narayan O, Forman J E, Halperin A, Hill T L, McCullagh P, Susan R Wilson, Yvonne Pittelkow, Zhang L   +14 more
core   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Nonequilibrium effects in DNA microarrays: a multiplatform study

, 2011
It has recently been shown that in some DNA microarrays the time needed to reach thermal equilibrium may largely exceed the typical experimental time, which is about 15h in standard protocols (Hooyberghs et al. Phys. Rev. E 81, 012901 (2010)).
Binder H., Binder H., Bloomfield V. A., Burden C. J., Burden C. J., Cantor C. R., Carlon E., E. Carlon, Fish D. J., Glazer M., Gray D. M., Hagan M. F., Halperin A., Halperin A., Hekstra D., Held G. A., Hooyberghs J., Hooyberghs J., J. Hooyberghs, J.-C. Walter, K. M. Kroll, Levicky R., Naiser T., Naiser T., Ono N., Peyret N., SantaLucia J., SantaLucia J., Suzuki S., Vainrub A., Weckx S., Zhang L., Zhang L.   +32 more
core   +3 more sources

Electrochemical Detection of Pathogens via DNA and Proteins Using CMOS-Based Microarrays [PDF]

, 2009
Kilian Dill, David L. Danley, Karl Maurer, John Cooper   +3 more
openalex   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Improvement in the amine glass platform by bubbling method for a DNA microarray

International Journal of Nanomedicine, 2015
Seung Hyun Jee,1 Jong Won Kim,2 Ji Hyeong Lee,2 Young Soo Yoon11Department of Chemical and Biological Engineering, Gachon University, Seongnam, Gyeonggi, Republic of Korea; 2Genomics Clinical Research Institute, LabGenomics Co., Ltd., Bundang-gu ...
Jee SH, Kim JW, Lee JH, Yoon YS
doaj