Results 91 to 100 of about 1,802,261 (296)

Differential gene expression graphs: A data structure for classification in DNA microarrays [PDF]

, 2008
This paper proposes an innovative data structure to be used as a backbone in designing microarray phenotype sample classifiers. The data structure is based on graphs and it is built from a differential analysis of the expression levels of healthy and ...
Stefano Di Carlo, Politano, Gianfranco Michele Maria, Benso, Alfredo, Sterpone, Luca, Gianfranco Politano, Di Carlo, Stefano, Alfredo Benso, Luca Sterpone   +7 more
core   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

A Platform for Combined DNA and Protein Microarrays Based on Total Internal Reflection Fluorescence

Sensors, 2012
We have developed a novel microarray technology based on total internal reflection fluorescence (TIRF) in combination with DNA and protein bioassays immobilized at the TIRF surface.
Alexander Asanov, Angélica Zepeda, Luis Vaca   +2 more
doaj   +1 more source

Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

Advanced Science, EarlyView.
A radical‐mediated in situ fluorescence dye deposition (RIFD) reaction containing merely three elements of beads, dyes, and radicals is discovered for the first time, and its underlying mechanism is elucidated. This simple RIFD enables the interfacial and ultrafast deposition of free dyes onto barcode beads, serving as a powerful signal amplification ...
Jiayu Zhang, Yao Wang, Xinyi Huang, Haiyu Wu, Qiuning Lin, Hongchen Gu, Li Jiang, Linyong Zhu, Hong Xu   +8 more
wiley   +1 more source

Development and application of a microarray meter tool to optimize microarray experiments

BMC Research Notes, 2008
Background Successful microarray experimentation requires a complex interplay between the slide chemistry, the printing pins, the nucleic acid probes and targets, and the hybridization milieu.
Rouse Richard JD, Field Katrine, Lapira Jennifer, Lee Allen, Wick Ivan, Eckhardt Colleen, Bhasker C Ramana, Soverchia Laura, Hardiman Gary   +8 more
doaj   +1 more source

Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples [PDF]

, 2011
Large-scale and in-depth characterization of the intestinal microbiota necessitates application of high-throughput 16S rRNA gene-based technologies, such as barcoded pyrosequencing and phylogenetic microarray analysis.
Vos, W.M., de, Bartholomeus van den Bogert, Kleerebezem, M., van den Bogert, B., Michiel Kleerebezem, Willem M. de Vos, Zoetendal, E.G., Bogert, B., van den, de Vos, W.M., Erwin G. Zoetendal   +9 more
core   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

An Overview of DNA Microarray Grid Alignment and Foreground Separation Approaches

EURASIP Journal on Advances in Signal Processing, 2006
This paper overviews DNA microarray grid alignment and foreground separation approaches. Microarray grid alignment and foreground separation are the basic processing steps of DNA microarray images that affect the quality of gene expression information ...
Bajcsy Peter
doaj   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Sensitivity and fidelity of DNA microarray improved with integration of Amplified Differential Gene Expression (ADGE)

BMC Genomics, 2003
Background The ADGE technique is a method designed to magnify the ratios of gene expression before detection. It improves the detection sensitivity to small change of gene expression and requires small amount of starting material. However, the throughput
Ile Kristina E, Davis Warren, Gaté Laurent, Chen Zhijian J, Tew Kenneth D   +4 more
doaj   +1 more source