Results 71 to 80 of about 1,802,261 (296)
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Molecules, 2003 We present a novel method for fabricating unimole cular double-stranded DNA microarrays on solid surfaces, which were used to probe sequence-specific DNA/protein interactions.
Zuhong Lu +4 more
doaj +1 more source
A Revised Design for Microarray Experiments to Account for Experimental Noise and Uncertainty of Probe Response [PDF]
, 2014 Background Although microarrays are analysis tools in biomedical research, they are known to yield noisy output that usually requires experimental confirmation.
Noble, P. +23 more
core +1 more source
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
Quantification of global transcription patterns in prokaryotes using spotted microarrays [PDF]
, 2007 We describe an analysis, applicable to any spotted microarray dataset produced using genomic DNA as a reference, that quantifies prokaryotic levels of mRNA on a genome-wide scale.
Sidders, B +63 more
core +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Navigating public microarray databases [PDF]
, 2004 With the ever-escalating amount of data being produced by genome-wide microarray studies, it is of increasing importance that these data are captured in public databases so that researchers can use this information to complement and enhance their own ...
Bähler, J, Penkett, CJ
core
Robust detection and identification of multiple oomycetes and fungi in environmental samples by using a novel cleavable padlock probe-based ligation-detection assay [PDF]
, 2009 Simultaneous detection and identification of multiple pathogenic microorganisms in complex environmental samples are required in numerous diagnostic fields.
Dullemans, A.M. +10 more
core +2 more sources
Advanced Science, EarlyView.In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu +12 more
wiley +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source