Results 61 to 70 of about 1,802,261 (296)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Gene expression profiles associated with stimulus-responsive insulin secretion in insulinoma

Endocrine Connections
Insulinoma is a functional pancreatic neuroendocrine tumor that usually causes fasting hypoglycemia through inappropriate autonomous insulin secretion.
Kenji Sugawara, Yuko Okada, Tomokazu Matsuda, Yushi Hirota, Shun-ichiro Asahara, Kazuhiko Sakaguchi, Wataru Ogawa   +6 more
doaj   +1 more source

Recent Advances in Light‐Addressable Electrochemistry for Spatially Resolved Applications

Advanced Materials Technologies, EarlyView.
This comprehensive review highlights light‐addressable electrochemistry as a powerful tool that uses light to control localized chemical reactions on unstructured semiconductor surfaces. The work evaluates advanced strategies to optimize electrode materials for enhanced spatial resolution and stability. Furthermore, it showcases diverse applications in
Nhi Trang Vo, Sina Jamali, Nam‐Trung Nguyen   +2 more
wiley   +1 more source

DNA methods for the detection of Phytophthora cinnamomi from soil [PDF]

, 2006
This project assesses two aspects of DNA detection of Phytophthora species from soil samples. Firstly, a nested PCR protocol was established with both primary and nested PCR specific for P. cinnamomi detection. PCR amplification of P.
Anderson, Nari Michelle
core  

A description of the origins, design and performance of the TRAITS-SGP Atlantic salmon Salmo salar L. cDNA microarray [PDF]

, 2008
The origins, design, fabrication and performance of an Atlantic salmon microarray are described. The microarray comprises 16 950 Atlantic salmon-derived cDNA features, printed in duplicate and mostly sourced from pre-existing expressed sequence tag (EST)
Carmichael, S. N., Carmichael, Stephen N, Teale, Alan J, C. J. Secombes (7674242), Tocher, D. R., Bron, James, Seear, P J, R. Talbot (7674227), Talbot, R, Martin, S. A. M., Villeneuve, L A N, Martin, S A M, Teale, A J, Seear, Paul J, Bron, J. E., Villeneuve, L. A. N., Sweeney, G E, Tocher, D R, D. R. Tocher (7674245), J. E. Bron (3151167), Seear, P. J., S. A. Martin (2499343), S. N. Carmichael (7674230), Høyheim, B., Paul J. Seear (3360119), Villeneuve, Laure, Martin, Sam A M, A. J. Teale (7674248), Secombes, C J, Secombes, C. J., Taggart, J. B., Tocher, Douglas R, Taggart, John, Høyheim, B, Carmichael, S N, Sweeney, Glen E., Sweeney, Glen E, Secombes, Christopher J, Hoyheim, Bjorn, L. A. Villeneuve (7674233), Houlihan, Dominic F, Bron, J E, Houlihan, D. F., B. Høyheim (7674224), J. B. Taggart (7674221), D. F. Houlihan (7674239), Taggart, J B, Talbot, R., G. E. Sweeney (7674236), Talbot, Richard T, Houlihan, D F, Teale, A. J.   +51 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

PLS dimension reduction for classification of microarray data [PDF]

, 2004
PLS dimension reduction is known to give good prediction accuracy in the context of classification with high-dimensional microarray data. In this paper, PLS is compared with some of the best state-of-the-art classification methods.
Boulesteix, Anne-Laure
core   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

ArrayQuest: a web resource for the analysis of DNA microarray data

BMC Bioinformatics, 2005
Background Numerous microarray analysis programs have been created through the efforts of Open Source software development projects. Providing browser-based interfaces that allow these programs to be executed over the Internet enhances the applicability ...
Barth Jeremy L, Jani Saurin, Argraves Gary L, Argraves W Scott   +3 more
doaj   +1 more source

Development and validation of a bovine macrophage specific cDNA microarray [PDF]

, 2006
Background The response of macrophages to danger signals is an important early stage in the immune response. Our understanding of this complex event has been furthered by microarray analysis, which allows the simultaneous investigation of the expression ...
Waddington David, Jensen Kirsty, Talbot, Richard, Edith Paxton, Talbot Richard, Elizabeth J Glass, Paxton Edith, Paxton, Edith, David Waddington, Kirsty Jensen, Jensen, Kirsty, Glass, Elizabeth, Waddington, David, Glass Elizabeth J, Richard Talbot   +14 more
core   +1 more source