Results 121 to 130 of about 414,545 (349)
Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]
, 2009 We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Atsushi Yoshiki +9 more
core +1 more source
A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application
Advanced Science, EarlyView.This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu +5 more
wiley +1 more source
Use of DNA microarray analysis in diagnosis of bacterial and fungal endophthalmitis
Clinical Ophthalmology, 2012 Tsutomu Sakai1, Kenichi Kohzaki1, Akira Watanabe1, Hiroshi Tsuneoka1, Mitsunobu Shimadzu21Department of Ophthalmology, Jikei University School of Medicine, 2Mitsubishi Chemical Medience Corporation, Tokyo, JapanBackground: To examine the utility of DNA ...
Sakai T +4 more
doaj
Advanced Science, EarlyView.This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim +10 more
wiley +1 more source
Advanced Science, EarlyView.THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu +10 more
wiley +1 more source
Advanced Science, EarlyView.sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang +7 more
wiley +1 more source
Dipodal Silanes Greatly Stabilize Glass Surface Functionalization for DNA Microarray Synthesis and High-Throughput Biological Assays. [PDF]
Anal Chem, 2023 Das A +8 more
europepmc +1 more source
Advanced Science, EarlyView.Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu +14 more
wiley +1 more source
DNA microarray technology in medical diagnostics
Zdravniški Vestnik, 2007 Background: DNA microarray technology opened a completely new venue in the biomedical research. By allowing to follow the expression of thousands of genes in a single experiment (ideally we can follow the expression of the entire genome), the microarray ...
Damjana Rozman, Peter Juvan
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RAID: Regression Analysis-Based Inductive DNA Microarray for Precise Read-Across. [PDF]
Front Pharmacol, 2022 Amano Y, Yamane M, Honda H.
europepmc +1 more source