Results 21 to 30 of about 177,132 (246)
Frontiers in Oncology, 2021 BackgroundWe previously reported that loss of KRAS mutations (“regressive” mutational trajectories) from primary tumors to metastases associated with the oligo-metastatic status in colorectal cancer (CRC).
Alessandro Ottaiano +17 more
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Nucleic acid mutation analysis using catalytic DNA
Nucleic Acids Research, 2000 The sequence specificity of the '10-23' RNA-cleaving DNA enzyme (deoxyribozyme) was utilised to discriminate between subtle differences in nucleic acid sequence in a relatively conserved segment of the L1 gene from a number of different human papilloma virus (HPV) genotypes.
M J, Cairns, A, King, L Q, Sun
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Ancient DNA Analysis of the Delta F508 Mutation
Human Biology, 2003 When working with highly degraded DNA, validating the results of a slightly polymorphic system always complicates the analysis because of the difficulties in recognizing contamination and artifacts. Recognition can be greatly simplified by employing a multiplex reaction that coamplifies the fragments together with several highly polymorphic markers ...
Bramanti, B +3 more
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Label-Free Detection of DNA Mutations by Nanopore Analysis [PDF]
ACS Applied Materials & Interfaces, 2018 Cancers are caused by mutations to genes that regulate cell normal functions. The capability to rapid and reliable detection of specific target gene variations can facilitate early disease detection and diagnosis and also enables personalized treatment of cancer.
Xiaohan Chen +6 more
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Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis [PDF]
Genomics & Informatics, 2013 In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in ...
Kye Hwa Lee, Jae Hyeun Lim, Ju Han Kim
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Mutational analysis of conserved residues in HhaI DNA methyltransferase [PDF]
Nucleic Acids Research, 2002 HhaI DNA methyltransferase belongs to the C5-cytosine methyltransferase family, which is characterized by the presence of a set of highly conserved amino acids and motifs present in an invariant order. HhaI DNA methyltransferase has been subjected to a lot of biochemical and crystallographic studies.
Sankpal, Umesh T, Rao, Desirazu N
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Journal of Indian Society of Pedodontics and Preventive Dentistry, 2020 A 7-month-old female child born to nonconsanguineous parents with a history of global developmental delay, since early infancy had reported to the department with facial features of mild dysmorphism.
Shaik Hasanuddin +2 more
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Frontiers in Oncology, 2022 BackgroundCirculating tumor DNA (ctDNA) sequence analysis shows great potential in the management of non-small cell lung cancer (NSCLC) and the prediction of drug sensitivity or resistance in many cancers.
Jun Cai +14 more
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PLoS Biology, 2019 Redox stress is a major hallmark of cancer. Analysis of thousands of sequenced cancer exomes and whole genomes revealed distinct mutational signatures that can be attributed to specific sources of DNA lesions.
Natalya P Degtyareva +6 more
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Accuracy of mutational signature software on correlated signatures
Scientific Reports, 2022 Mutational signatures are characteristic patterns of mutations generated by exogenous mutagens or by endogenous mutational processes. Mutational signatures are important for research into DNA damage and repair, aging, cancer biology, genetic toxicology ...
Yang Wu +4 more
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