Results 1 to 10 of about 182,601 (264)

Clinical Implications of Circulating Tumor DNA Tumor Mutational Burden (ctDNA TMB) in Non-Small Cell Lung Cancer

Oncologist, 2019
Nisha Mohindra, Gilberto Lopes, Francis Giles   +2 more
exaly  

DNA strand biases and the mutational resilience of genes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998
exaly  

DNA methylation and mutational analysis methods for bladder cancer surveillance

2018
LOPATIN MARGARITA, TSIATIS ATHANASIOS, SILK CHRISTOPHER N, MILLER DAVID P, CRAGER MICHAEL, FEBBO PHILLIP, KNEZEVIC DEJAN   +6 more
openaire   +3 more sources

MUTATIONAL ANALYSIS OF PLASMA DNA FOR CANCER DETECTION

2013
LO YUK-MING DENNIS, CHIU ROSSA WAI KWUN, CHAN KWAN CHEE, JIANG PEIYONG   +3 more
openaire   +12 more sources

A framework for mutational signature analysis based on DNA shape parameters. [PDF]

PLoS ONE, 2022
The mutation risk of a DNA locus depends on its oligonucleotide context. In turn, mutability of oligonucleotides varies across individuals, due to exposure to mutagenic agents or due to variable efficiency and/or accuracy of DNA repair.
Aleksandra Karolak, Jurica Levatić, Fran Supek   +2 more
doaj   +5 more sources

A mutational scar-based genome-wide map of DNA double-strand break repair [PDF]

Nature Communications
Genome alterations arise from inaccurate DNA repair and accumulate as distinct mutational signatures. Here, we systematically interrogate the contribution of every protein-coding gene to double-strand break (DSB) repair by generating high-resolution ...
Marco Barazas, Robin van Schendel, Marcel Tijsterman   +2 more
doaj   +2 more sources

DNA phosphorothioation in Streptomyces lividans: mutational analysis of the dnd locus [PDF]

BMC Microbiology, 2009
Background A novel DNA phosphorothioate modification (DNA sulfur modification), in which one of the non-bridging oxygen atoms in the phosphodiester bond linking DNA nucleotides is exchanged by sulphur, was found to be genetically determined by dnd or dnd-
Xu Zhongli, Li Aiying, Wang Zhijun, You Delin, He Xinyi, Wang Lianrong, Chen Shi, Liang Jingdan, Xu Tiegang, Zhou Xiufen, Deng Zixin   +10 more
doaj   +3 more sources

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate

Scientific Reports, 2023
Cancer somatic mutations are the product of multiple mutational and repair processes, some of which are tightly associated with DNA replication. Mutation rates (MR) are known to be higher in late replication timing (RT) regions, but different processes ...
Oriya Vardi-Yaacov, Adar Yaacov, Shai Rosenberg, Itamar Simon   +3 more
doaj   +1 more source

Mutational spectra are associated with bacterial niche

Nature Communications, 2023
As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells.
Christopher Ruis, Aaron Weimann, Gerry Tonkin-Hill, Arun Prasad Pandurangan, Marta Matuszewska, Gemma G. R. Murray, Roger C. Lévesque, Tom L. Blundell, R. Andres Floto, Julian Parkhill   +9 more
doaj   +1 more source

Mitochondrial DNA mutations in Medulloblastoma

Acta Neuropathologica Communications, 2023
To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this tumour entity and led to its division into four groups—WNT, SHH, group 3 (G3) and group 4 (G4).
Viktoria L. E. Funke, Sarah Sandmann, Viktoria Melcher, Jochen Seggewiss, Judit Horvath, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Stefan Rutkowski, Martin Mynarek, Julian Varghese, Ronald Sträter, Stephan Rust, Anja Seelhöfer, Janine Reunert, Barbara Fiedler, Ulrich Schüller, Thorsten Marquardt, Kornelius Kerl   +20 more
doaj   +1 more source