Results 21 to 30 of about 182,601 (264)
Chitosan-modified graphene electrodes for DNA mutation analysis [PDF]
Journal of Electroanalytical Chemistry, 2012 Graphene has remarkable electrochemical properties that make it an ideal material for constructing biosensors,however it has not been explored for DNA biosensing. Herein, we report on a chitosan-modified graphene platform for the electrochemical detection of changes in DNA sequences.
Subbiah, Alwarappan +4 more
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Genome Medicine, 2020 Background Studies of cancer mutations have typically focused on identifying cancer driving mutations that confer growth advantage to cancer cells. However, cancer genomes accumulate a large number of passenger somatic mutations resulting from various ...
Yoo-Ah Kim +9 more
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Quantitative Mitochondrial DNA Mutation Analysis by Denaturing HPLC [PDF]
Clinical Chemistry, 2007 AbstractBackground: In recent years, denaturing HPLC (DHPLC) has been widely used to screen the whole mitochondrial genome or specific regions of the genome for DNA mutations. The quantification and mathematical modeling of DHPLC results is, however, underexplored.Methods: We generated site-directed mutants containing some common mutations in the ...
Kok Seong, Lim +2 more
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Gut and Liver, 2017 Background/Aimsα-Fetoprotein (AFP) is normally 1 year, and 20 controls with low AFP levels (
Yejoo Jeon +4 more
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Ancient DNA Analysis of the Delta F508 Mutation
Human Biology, 2003 When working with highly degraded DNA, validating the results of a slightly polymorphic system always complicates the analysis because of the difficulties in recognizing contamination and artifacts. Recognition can be greatly simplified by employing a multiplex reaction that coamplifies the fragments together with several highly polymorphic markers ...
Bramanti, B +3 more
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Two different homozygous mutations in two Turkish siblings: DGUOK and HPS5
Journal of Biochemical and Clinical Genetics, 2020 Background: Genetic disorders are enormously diverse both in terms of genotype and phenotype. Each case requires a careful and cautious investigation. Case Presentation: In this paper, we report two siblings who were admitted to our clinic with various ...
Muhsin Elmas +6 more
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Label-Free Detection of DNA Mutations by Nanopore Analysis [PDF]
ACS Applied Materials & Interfaces, 2018 Cancers are caused by mutations to genes that regulate cell normal functions. The capability to rapid and reliable detection of specific target gene variations can facilitate early disease detection and diagnosis and also enables personalized treatment of cancer.
Xiaohan Chen +6 more
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Journal of Indian Society of Pedodontics and Preventive Dentistry, 2020 A 7-month-old female child born to nonconsanguineous parents with a history of global developmental delay, since early infancy had reported to the department with facial features of mild dysmorphism.
Shaik Hasanuddin +2 more
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Frontiers in Oncology, 2021 BackgroundWe previously reported that loss of KRAS mutations (“regressive” mutational trajectories) from primary tumors to metastases associated with the oligo-metastatic status in colorectal cancer (CRC).
Alessandro Ottaiano +17 more
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Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis [PDF]
Genomics & Informatics, 2013 In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in ...
Kye Hwa Lee, Jae Hyeun Lim, Ju Han Kim
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