Results 1 to 10 of about 3,282,242 (309)
Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair. [PDF]
Theranostics, 2022 The efficiency of gene therapy is often dictated by the gene delivery system. Cationic polymers are essential elements of gene delivery systems. The relatively cheap cationic polymer, polyethyleneimine, has high gene delivery efficiency and is often used
Kim HJ +7 more
europepmc +2 more sources
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Experimental and Molecular Medicine, 2023 Inflammatory diseases: Understanding mitochondrial DNA release Cytosolic DNA activates the cGAS-STING pathway which mediates inflammation and antiviral response. One source of cytosolic DNA is ‘self ‘ DNA, such as mitochondrial DNA.
Jeonghan Kim, Ho-Shik Kim, Jay H. Chung
doaj +2 more sources
The Mitochondrial Response to DNA Damage
Frontiers in Cell and Developmental Biology, 2021 Mitochondria are double membrane organelles in eukaryotic cells that provide energy by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are crucial to many aspects of cellular metabolism.
Ziye Rong +7 more
doaj +2 more sources
Mitochondrial DNA, mitochondrial dysfunction, and cardiac manifestations.
Frontiers in Bioscience, 2017 Mitochondria, the powerhouses of cells, have their own DNA (mtDNA). They regulate the transport of metabolites and ions, which determine cell physiology, survival, and death. Mitochondrial dysfunction, including impaired oxidative phosphorylation, preferentially affects heart function via imbalance of energy supply and demand.
Sung Ryul Lee +6 more
semanticscholar +4 more sources
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
bioRxiv, 2023 Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of mtDNA detection by cytosolic nucleic acid sensors remain poorly defined.
Yuanjiu Lei +21 more
semanticscholar +1 more source
Case Reports in Genetics, 2021 Mitochondrial DNA (mtDNA) depletion syndromes are a group of autosomal recessive disorders associated with a spectrum of clinical diseases, which include progressive external ophthalmoplegia (PEO).
Justin Kurtz +4 more
doaj +1 more source
Nature Communications, 2023 DNA derived from chemotherapeutics-killed tumor cells is one of the most important damage-associated molecular patterns that can activate the cGAS-STING (cyclic GMP-AMP synthase—stimulator of interferon genes) pathway in antigen-presenting cells (APCs ...
Chaoyu Wang +10 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 One of the most proliferative periods for T cells occurs during their development in the thymus. Increased DNA replication can result in increased DNA mutations in the nuclear genome, but also in mitochondrial genomes.
Candice B. Limper +8 more
doaj +1 more source
Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging
Genome Biology, 2020 Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease.
Scott A. Lujan +12 more
doaj +1 more source
The Mighty NUMT: Mitochondrial DNA Flexing Its Code in the Nuclear Genome
Biomolecules, 2023 Nuclear-mitochondrial DNA segments (NUMTs) are mitochondrial DNA (mtDNA) fragments that have been inserted into the nuclear genome. Some NUMTs are common within the human population but most NUMTs are rare and specific to individuals. NUMTs range in size
Liying Xue +3 more
doaj +1 more source