Results 21 to 30 of about 614,734 (318)

A Complete Mitochondrial Genome Sequence from a Mesolithic Wild Aurochs (Bos primigenius) [PDF]

, 2010
Background The derivation of domestic cattle from the extinct wild aurochs (Bos primigenius) has been well-documented by archaeological and genetic studies.
Finlay Emma K., Park Stephen D. E., Daniel G Bradley, Shapiro Beth, Edwards Ceiridwen J., Ceiridwen J Edwards, Murphy, A., MacHugh David E., Beth Shapiro, Edwards, C.J., Bradley Daniel G., Park, S.D.E., MacHugh, D.E., McGettigan, Paul A., Shapiro, Beth, Alison Murphy, Martin B Richards, Chamberlain Andrew T., Loftus Brendan J., Murphy, Alison, Bradley, D.G., Knapp, Michael, David A Magee, Amanda J Lohan, Magee David A., Stephen D E Park, Lohan, A.J., Shapiro, B., Magee, David A., Bradley, Daniel G., Brendan J Loftus, Richards Martin B., Richards, M.B., Paul A McGettigan, Loftus, Brendan J., Park, Stephen D E, David E MacHugh, Chamberlain, Andrew T., Murphy Alison, MacHugh, David E., Andrew T Chamberlain, Park, Stephen D. E., Lohan, Amanda J., Lohan Amanda J., Loftus, B.J., Finlay, Emma K., McGettigan, P.A., Finlay, E.K., Richards, Martin B., Magee, D.A., Emma K Finlay, McGettigan Paul A., Chamberlain, A.T., Edwards, Ceiridwen J.   +53 more
core   +1 more source

DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging

Journal of Aging Research, 2011
During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging.
Ricardo Gredilla
doaj   +1 more source

Mitochondrial DNA sequencing of a wet-collection syntype demonstrates the importance of type material as genetic resource for lantern shark taxonomy (Chondrichthyes: Etmopteridae)

Royal Society Open Science, 2021
After initial detection of target archival DNA of a 116-year-old syntype specimen of the smooth lantern shark, Etmopterus pusillus, in a single-stranded DNA library, we shotgun-sequenced additional 9 million reads from this same DNA library.
Nicolas Straube, Michaela Preick, Gavin J. P. Naylor, Michael Hofreiter   +3 more
doaj   +1 more source

DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction

Journal of Advanced Research, 2022
Introduction: Multiple organ failure is the commonest cause of death in septic patients. Objectives: This study was undertaken in an attempt to elucidate the functional importance of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on ...
Rongjun Zou, Jun Tao, Junxiong Qiu, Huimin Lu, Jianhua Wu, Hang Zhu, Ruibing Li, David Mui, Sam Toan, Xing Chang, Hao Zhou, Xiaoping Fan   +11 more
doaj   +1 more source

Defects of Mitochondrial DNA

Brain Pathology, 1992
In the past few years several syndromes have been associated with lesions of the human mitochondrial DNA. MtDNA is a small, circular extra‐nuclear chromosome encoding essential components of the respiratory chain. MtDNA‐related syndromes can be divided into two groups: mitochondrial encephalomyopathies, characterized by the presence of ragged‐red ...
Zeviani M., Antozzi C.
openaire   +2 more sources

A rapid and efficient method for enriching mitochondrial DNA from plants

Mitochondrial DNA. Part B. Resources, 2018
Current mitochondrial purification techniques are tedious and protracted due to their emphasis on recovering physiologically active mitochondria. However, for studies that are exclusively interested in isolating mitochondrial DNA (mtDNA) for applications
Mackenzie M. Strehle, Emma Purfeerst, Alan C. Christensen   +2 more
doaj   +1 more source

The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?

Cells, 2022
Mitochondria are well known as ‘the powerhouses of the cell’. Indeed, their major role is cellular energy production driven by both mitochondrial and nuclear DNA.
Amira Podolak, Izabela Woclawek-Potocka, Krzysztof Lukaszuk   +2 more
doaj   +1 more source

Mitochondrial DNA and disease [PDF]

The Journal of Pathology, 2011
AbstractMitochondrial DNA (mtDNA) defects are a relatively common cause of inherited disease and have been implicated in both ageing and cancer. MtDNA encodes essential subunits of the mitochondrial respiratory chain and defects result in impaired oxidative phosphorylation (OXPHOS).
Laura C, Greaves, Amy K, Reeve, Robert W, Taylor, Doug M, Turnbull   +3 more
openaire   +2 more sources

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA [PDF]

, 2014
The manifestation of mitochondrial DNA (mtDNA) diseases depends on the frequency of heteroplasmy (the presence of several alleles in an individual), yet its transmission across generations cannot be readily predicted owing to a lack of data on the size ...
Chiaromonte, Francesca, T. S. Korneliussen, D. Blankenberg, Blankenberg, Daniel, Korneliussen, Thorfinn Sand, I. M. Paul, Paul, IM, Holland, Mitchell M, Su, Marcia Shu-Wei, B. Rebolledo-Jaramillo, Su, MS-W, B. Dickins, A. Nekrutenko, McElhoe, Jennifer A., R. Nielsen, N. Stoler, Nielsen, Rasmus, Nekrutenko, A, Makova, Kateryna D., Stoler, Nicholas, McElhoe, Jennifer A, Korneliussen, Thorfinn S., Chiaromonte, F, Holland, MM, M. S.-W. Su, Nekrutenko, Anton, Nielsen, R, Makova, KD, J. A. McElhoe, Rebolledo-Jaramillo, Boris, Rebolledo-Jaramillo, B, Korneliussen, Thorfinn S, Makova, Kateryna D, M. M. Holland, Holland, Mitchell M., Stoler, N, Blankenberg, D, F. Chiaromonte, Paul, Ian M., Paul, Ian M, K. D. Makova, Korneliussen, TS, McElhoe, JA, Dickins, Benjamin, Dickins, B   +44 more
core   +1 more source

Clinical features of the late ⁃ onset mitochondrial encephalomyopathy with lactic acidosis and stroke⁃like episodes

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To summarize the clinical, pathological and genetic features of 10 patients with late ⁃ onset mitochondrial encephalomyopathy with lactic acidosis and stroke ⁃ like episodes (MELAS).
Dan⁃hua ZHAO, Xu⁃tong ZHAO, Hai⁃ying XING, Xiao ZHANG, Zhe ZHANG, Xian⁃zeng LIU, Yun YUAN, Zhao⁃xia WANG   +7 more
doaj