Results 21 to 30 of about 3,282,242 (309)

Mitochondrial DNA in inflammation and immunity

EMBO Reports, 2020
Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation.
Joel S. Riley, S. Tait
semanticscholar   +1 more source

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

Autophagy, 2020
Pancreatic cancer tends to be highly resistant to current therapy and remains one of the great challenges in biomedicine with very low 5-year survival rates.
Changfeng Li, Ying Zhang, Jiao Liu, R. Kang, D. Klionsky, D. Tang   +5 more
semanticscholar   +1 more source

Neuropathic Pain as Main Manifestation of POLG-Related Disease: A Case Report

Frontiers in Neurology, 2022
Mutations in nuclear-encoded genes that are involved in mitochondrial DNA replication and maintenance (e.g., POLG) have been associated with chronic progressive external ophthalmoplegia (CPEO) phenotype.
Melanie Lang-Orsini, Paloma Gonzalez-Perez   +1 more
doaj   +1 more source

Mitochondrial DNA copy number in human disease: the more the better?

FEBS Letters, 2020
Most of the genetic information has been lost or transferred to the nucleus during the evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that is essential for oxidative phosphorylation (OXPHOS). In mammals, a gene‐dense
R. Filograna, M. Mennuni, David Alsina, N. Larsson   +3 more
semanticscholar   +1 more source

Plant mitochondrial DNA

Frontiers in Bioscience, 2017
Plants possess mitochondrial genomes that are large and complex compared to animals. Nearly all animal mitochondrial genomes are about 16.5. kbp in length, whereas plant mitochondrial genomes range between 200-2,000 kbp. This is curious if we assume modern mitochondria originated from a common alpha-proteobacterial ancestor.
Stewart A, Morley, Brent L, Nielsen
openaire   +2 more sources

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

BioMed Research International, 2014
Usually the genetics of human longevity is restricted to the nuclear genome (nDNA). However it is well known that the nDNA interacts with a physically and functionally separated genome, the mitochondrial DNA (mtDNA) that, even if limited in length and ...
P. Garagnani, C. Pirazzini, C. Giuliani, M. Candela, P. Brigidi, F. Sevini, D. Luiselli, M. Bacalini, S. Salvioli, M. Capri, D. Monti, D. Mari, S. Collino, M. Delledonne, P. Descombes, C. Franceschi   +15 more
semanticscholar   +1 more source

Mitochondrial DNA and disease [PDF]

The Journal of Pathology, 2011
AbstractMitochondrial DNA (mtDNA) defects are a relatively common cause of inherited disease and have been implicated in both ageing and cancer. MtDNA encodes essential subunits of the mitochondrial respiratory chain and defects result in impaired oxidative phosphorylation (OXPHOS).
Laura C, Greaves, Amy K, Reeve, Robert W, Taylor, Doug M, Turnbull   +3 more
openaire   +2 more sources

DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging

Journal of Aging Research, 2011
During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging.
Ricardo Gredilla
doaj   +1 more source

Mitochondrial DNA sequencing of a wet-collection syntype demonstrates the importance of type material as genetic resource for lantern shark taxonomy (Chondrichthyes: Etmopteridae)

Royal Society Open Science, 2021
After initial detection of target archival DNA of a 116-year-old syntype specimen of the smooth lantern shark, Etmopterus pusillus, in a single-stranded DNA library, we shotgun-sequenced additional 9 million reads from this same DNA library.
Nicolas Straube, Michaela Preick, Gavin J. P. Naylor, Michael Hofreiter   +3 more
doaj   +1 more source

Mitochondrial DNA Activates cGAS Signaling and Suppresses YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

Immunity, 2020
Summary Cytosolic DNA acts as a universal danger-associated molecular pattern (DAMP) signal; however, the mechanisms of self-DNA release into the cytosol and its role in inflammatory tissue injury are not well understood.
L. Huang, Z. Hong, Wei Wu, Shiqin Xiong, Ming Zhong, Xiao‐pei Gao, J. Rehman, A. Malik   +7 more
semanticscholar   +1 more source