Results 41 to 50 of about 614,734 (318)

Mitochondrial DNA and ageing

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006
The accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. Although mitochondria have long been anticipated as a perpetrator of ageing, there was little experimental evidence to link these changes directly with the cellular pathology of ageing.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

MITOCHONDRIAL DNA POLYMORPHISMS AND FERTILITY IN BEEF CATTLE [PDF]

, 2002
Two regions of mitochondrial DNA, D-loop and ND-5 were characterized using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) involving 422 beef cattle of Hereford and composite breeds from Wokalup’s ...
A.J, Lymbery, J.M, Cummins, ., Sutarno, RCA, Thompson   +3 more
core  

Complete mitochondrial genomes of two marine monogonont rotifer Brachionus manjavacas strains

Mitochondrial DNA. Part B. Resources, 2021
The complete mitochondrial genomes of Brachionus manjavacas German strain were 10,721 bp (mitochondrial DNA I) and 12,274 bp (mitochondrial DNA II) in size, while the complete mitochondrial genomes of B.
Min-Sub Kim, Young Hwan Lee, Duck-Hyun Kim, Hee-Jin Kim, Un-Ki Hwang, Russell Shiel, Atsushi Hagiwara, Jae-Seong Lee   +7 more
doaj   +1 more source

Ribonucleotides in mitochondrial DNA [PDF]

FEBS Letters, 2019
The incorporation of ribonucleotides (rNMPs) into DNA during genome replication has gained substantial attention in recent years and has been shown to be a significant source of genomic instability. Studies in yeast and mammals have shown that the two genomes, the nuclear DNA (nDNA) and the mitochondrial DNA (mtDNA), differ with regard to their rNMP ...
Wanrooij, Paulina H., Chabes, Andrei
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors [PDF]

, 2011
Interspecies somatic cell nuclear transfer (iSCNT) involves the transfer of a nucleus or cell from one species into the cytoplasm of an enucleated oocyte from another.
St. John Justin C., Dickinson Adam, Daniel A Mitchell, Yan Jiang, Kelly Richard, Peters Amy, Fulka, Helena, Helena Fulka, Justin C. St. John, Dickinson, Adam, St. John, Justin C., Adam Dickinson, Daniel A. Mitchell, Justin C St John, Jiang Yan, Fulka Helena, Kelly, Richard D. W., Mitchell Daniel A., Mitchell, Daniel A., Peters, Amy, Richard Kelly, Jiang, Yan, Amy Peters   +22 more
core   +1 more source

Mitochondrial DNA in osteoarthritis disease [PDF]

Clinical Rheumatology, 2020
[Abstract] Osteoarthritis (OA) is the most prevalent chronic joint disease, and we actually know that the activation of maladaptive responses to injury, including pro-inflammatory pathways, leads to the loss of normal joint function characterized by cartilage degradation, bone remodeling, osteophyte formation, and joint inflammation [1].
Francisco J. Blanco, Ignacio Rego-Pérez
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Meta-Analysis of Mitochondrial DNA Reveals Several Population Bottlenecks during Worldwide Migrations of Cattle [PDF]

, 2014
Several studies have investigated the differentiation of mitochondrial DNA in Eurasian, African and American cattle as well as archaeological bovine material.
Ginja, Catarina, David A. Magee, Ceiridwen J. Edwards, Ferretti, Luca, Beja-Pereira, Albano, Negrini, Riccardo, Marleen Felius, Juha Kantanen, Ajmone-Marsan, Paolo, Algemeen Onderzoek DGK, Lenstra, Johannes, Licia Colli, Bollongino, Ruth, Radoslavov, Georgi A., David Magee, Juan Pedro Lirón, Georgi A. Radoslavov, Ruth Bollongino, Ajmone Marsan, Paolo, Luca Ferretti, Magee, David A., Ceiridwen Edwards, Juan Lirón, Daniel G. Bradley, Riccardo Negrini, Hristov, Peter, Lenstra, Johannes A., Johannes A. Lenstra, Paolo Ajmone-Marsan, Catarina Ginja, Bradley, Daniel G., Johannes Lenstra, Albano Beja Pereira, Paolo Ajmone Marsan, Daniel Bradley, LS IRAS Tox Algemeen, Georgi Radoslavov, Peter Hristov, Beja Pereira, Albano, De Gaetano, Anna, Colli, Licia, Radoslavov, Georgi, Albano Beja-Pereira, Lirón, Juan Pedro, Anna De Gaetano, Lirón, Juan, Kantanen, Juha, Edwards, Ceiridwen J., Felius, Marleen   +48 more
core   +1 more source