Results 31 to 40 of about 3,282,242 (309)

Defects of Mitochondrial DNA

Brain Pathology, 1992
In the past few years several syndromes have been associated with lesions of the human mitochondrial DNA. MtDNA is a small, circular extra‐nuclear chromosome encoding essential components of the respiratory chain. MtDNA‐related syndromes can be divided into two groups: mitochondrial encephalomyopathies, characterized by the presence of ragged‐red ...
Zeviani M., Antozzi C.
openaire   +2 more sources

A rapid and efficient method for enriching mitochondrial DNA from plants

Mitochondrial DNA. Part B. Resources, 2018
Current mitochondrial purification techniques are tedious and protracted due to their emphasis on recovering physiologically active mitochondria. However, for studies that are exclusively interested in isolating mitochondrial DNA (mtDNA) for applications
Mackenzie M. Strehle, Emma Purfeerst, Alan C. Christensen   +2 more
doaj   +1 more source

DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction

Journal of Advanced Research, 2022
Introduction: Multiple organ failure is the commonest cause of death in septic patients. Objectives: This study was undertaken in an attempt to elucidate the functional importance of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on ...
Rongjun Zou, Jun Tao, Junxiong Qiu, Huimin Lu, Jianhua Wu, Hang Zhu, Ruibing Li, David Mui, Sam Toan, Xing Chang, Hao Zhou, Xiaoping Fan   +11 more
doaj   +1 more source

The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?

Cells, 2022
Mitochondria are well known as ‘the powerhouses of the cell’. Indeed, their major role is cellular energy production driven by both mitochondrial and nuclear DNA.
Amira Podolak, Izabela Woclawek-Potocka, Krzysztof Lukaszuk   +2 more
doaj   +1 more source

A new method for long-read sequencing of animal mitochondrial genomes: application to the identification of equine mitochondrial DNA variants

BMC Genomics, 2020
Background Mitochondrial DNA is remarkably polymorphic. This is why animal geneticists survey mitochondrial genomes variations for fundamental and applied purposes.
Sophie Dhorne-Pollet, Eric Barrey, Nicolas Pollet   +2 more
doaj   +1 more source

Clinical features of the late ⁃ onset mitochondrial encephalomyopathy with lactic acidosis and stroke⁃like episodes

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To summarize the clinical, pathological and genetic features of 10 patients with late ⁃ onset mitochondrial encephalomyopathy with lactic acidosis and stroke ⁃ like episodes (MELAS).
Dan⁃hua ZHAO, Xu⁃tong ZHAO, Hai⁃ying XING, Xiao ZHANG, Zhe ZHANG, Xian⁃zeng LIU, Yun YUAN, Zhao⁃xia WANG   +7 more
doaj  

Structure–Function Analysis Reveals the Singularity of Plant Mitochondrial DNA Replication Components: A Mosaic and Redundant System

Plants, 2019
Plants are sessile organisms, and their DNA is particularly exposed to damaging agents. The integrity of plant mitochondrial and plastid genomes is necessary for cell survival.
Luis Gabriel Brieba
doaj   +1 more source

Mitochondrial DNA homeostasis: A novel therapeutic target for neurodegenerative diseases

Neural Regeneration Research
The mitochondrial genomic homeostasis is essential for the function of the oxidative phosphorylation system and cellular homeostasis. Mitochondrial DNA is particularly susceptible to aging-related oxidative stress due to the lack of a histone coat ...
Tingting Fu, Xinyi Chen, Shuting Zhang, Ying Fu, Ling Huang, Wandi Xiong   +5 more
doaj   +1 more source

Mechanisms of replication and repair in mitochondrial DNA deletion formation

Nucleic Acids Research, 2020
Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases in length and the loss of these associated genes contributes to crippled ...
Gabriele A. Fontana, Hailey L. Gahlon
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source