Results 31 to 40 of about 2,421,986 (315)

Neuropathic Pain as Main Manifestation of POLG-Related Disease: A Case Report

Frontiers in Neurology, 2022
Mutations in nuclear-encoded genes that are involved in mitochondrial DNA replication and maintenance (e.g., POLG) have been associated with chronic progressive external ophthalmoplegia (CPEO) phenotype.
Melanie Lang-Orsini, Paloma Gonzalez-Perez   +1 more
doaj   +1 more source

Plant mitochondrial DNA

Frontiers in Bioscience, 2017
Plants possess mitochondrial genomes that are large and complex compared to animals. Nearly all animal mitochondrial genomes are about 16.5. kbp in length, whereas plant mitochondrial genomes range between 200-2,000 kbp. This is curious if we assume modern mitochondria originated from a common alpha-proteobacterial ancestor.
Stewart A, Morley, Brent L, Nielsen
openaire   +2 more sources

Defects of Mitochondrial DNA

Brain Pathology, 1992
In the past few years several syndromes have been associated with lesions of the human mitochondrial DNA. MtDNA is a small, circular extra‐nuclear chromosome encoding essential components of the respiratory chain. MtDNA‐related syndromes can be divided into two groups: mitochondrial encephalomyopathies, characterized by the presence of ragged‐red ...
Zeviani M., Antozzi C.
openaire   +2 more sources

Mitochondrial DNA and disease [PDF]

The Journal of Pathology, 2011
AbstractMitochondrial DNA (mtDNA) defects are a relatively common cause of inherited disease and have been implicated in both ageing and cancer. MtDNA encodes essential subunits of the mitochondrial respiratory chain and defects result in impaired oxidative phosphorylation (OXPHOS).
Laura C, Greaves, Amy K, Reeve, Robert W, Taylor, Doug M, Turnbull   +3 more
openaire   +2 more sources

Reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy [PDF]

, 2013
Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce.
Miró Meda, José M. (José María), 1956-, Cardellach, Francesc, López Moreno, Sònia, Martínez, Esteban, Blanco, José L., Milinkovic, Ana, Rodríguez Santiago, Benjamín, Gatell, José M., Nunes Martínez, Virginia, Casademont i Pou, Jordi, Miró i Andreu, Òscar   +10 more
core   +1 more source

Mitochondrial DNA in Sepsis [PDF]

Current Opinion in Critical Care, 2017
Purpose of review Our understanding of critical illness is transforming as we develop a better understanding of the impact pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) have on the pathogenesis of disease. Of the known DAMPs, there is a growing interest in mitochondrial DNA (mtDNA) as a
John S, Harrington, Augustine M K, Choi, Kiichi, Nakahira   +2 more
openaire   +2 more sources

Mitochondrial DNA Backgrounds Might Modulate Diabetes Complications Rather than T2DM as a Whole [PDF]

, 2011
Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Additionally, rare mitochondrial DNA (mtDNA) mutations have been shown to be causal for T2DM pathogenesis.
Baharak Hooshiar Kashani, Antonella Cormio, TORRONI A., Pala M., MARRA M, Santoro Aurelia, Lancioni, Hovirag, ACHILLI A, Viola Grugni, Lancioni Hovirag, Grugni V., Cormio Antonella, Sirolla, Cristina, GRUGNI V, Anna Olivieri, Franceschi Claudio, Spazzafumo L., Cormio, Antonella, Testa Roberto, SIROLLA C, Torroni, Antonio, Ugo A. Perego, Hooshiar Kashani, Baharak, PEREGO UA, Boemi, Massimo, Grugni Viola, Olivieri Anna, Grugni, Viola, Hooshiar Kashani Baharak, Gadaleta Maria Nicola, Testa I., Bonfigli, Anna Rita, Vincenza Battaglia, PEREGO, UGO ALESSANDRO, Achilli A., Roberto Testa, Achilli A1, GANDINI F, TESTA I, Antonio Ceriello, Pala Maria, Gandini Francesca, TESTA R, Marra M., Spazzafumo, Liana, Testa R., Testa, Roberto, Semino Ornella, Marra, Maurizio, Carossa Valeria, Anna Rita Bonfigli, Cormio A, SPAZZAFUMO L, Maria Pala, Olivieri A., Ivano Testa, Olivieri, Anna, BOEMI M, Marra Maurizio, Perego, Ugo A., SANTORO A, SEMINO O, Achilli Alessandro, HOOSHIAR KASHANI B, Boemi M., Spazzafumo Liana, Battaglia V., Hooshiar Kashani B., Testa, Ivano, Aurelia Santoro, Torroni Antonio, Ceriello, Antonio, Boemi Massimo, Massimo Boemi, Valeria Carossa, Bonfigli A. R., LANCIONI H, Gandini, Francesca, Sirolla Cristina, Battaglia Vincenza, Gadaleta, Maria Nicola, BATTAGLIA V, Sirolla C., Santoro, Aurelia, Bonfigli Anna Rita, Gadaleta M. N., Ceriello A., Carossa, Valeria, CAROSSA V, Pala, Maria, FRANCESCHI C, Semino O., Ceriello Antonio, Ugo A Perego, Antonio Torroni, Maria Nicola Gadaleta, Testa Ivano, Perego U. A., BONFIGLI AR, Ornella Semino, Franceschi, Claudio, Maurizio Marra, Hovirag Lancioni, Battaglia, Vincenza, Achilli, Alessandro, Semino, Ornella, CERIELLO A, GADALETA MN, Francesca Gandini, PALA M, Carossa V., Cormio A., Lancioni H., OLIVIERI A, Perego Ugo A., Alessandro Achilli, Claudio Franceschi, Gandini F., Cristina Sirolla, Liana Spazzafumo   +119 more
core   +2 more sources

Mitochondrial DNA lineages of Italian Giara and Sarcidano horses [PDF]

, 2014
Giara and Sarcidano are 2 of the 15 extant native Italian horse breeds with limited dispersal capability that originated from a larger number of individuals. The 2 breeds live in two distinct isolated locations on the island of Sardinia. To determine the
Cancedda, M., Cancedda M, Francalacci, P., Pala, Maria, Contu D, Morelli, L., Contu, D., Useli A, Barbato, M., Useli, A., FRANCALACCI, Paolo, Francalacci P, Sanna D, Morelli L, Sanna, D., Pala M, Barbato M, Contu D., Pala M., Pala, M.; id_orcid, Sanna D., Cancedda M., Morelli L., Useli A., Francalacci P., Barbato M.   +25 more
core   +1 more source

DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging

Journal of Aging Research, 2011
During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging.
Ricardo Gredilla
doaj   +1 more source

DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction

Journal of Advanced Research, 2022
Introduction: Multiple organ failure is the commonest cause of death in septic patients. Objectives: This study was undertaken in an attempt to elucidate the functional importance of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on ...
Rongjun Zou, Jun Tao, Junxiong Qiu, Huimin Lu, Jianhua Wu, Hang Zhu, Ruibing Li, David Mui, Sam Toan, Xing Chang, Hao Zhou, Xiaoping Fan   +11 more
doaj   +1 more source