Results 51 to 60 of about 2,304,173 (313)

Mitochondrial DNA homeostasis: A novel therapeutic target for neurodegenerative diseases

Neural Regeneration Research
The mitochondrial genomic homeostasis is essential for the function of the oxidative phosphorylation system and cellular homeostasis. Mitochondrial DNA is particularly susceptible to aging-related oxidative stress due to the lack of a histone coat ...
Tingting Fu, Xinyi Chen, Shuting Zhang, Ying Fu, Ling Huang, Wandi Xiong   +5 more
doaj   +1 more source

Determination of Mitochondrial DNA Upon Drug Treatment

Bio-Protocol, 2015
Drug-induced mitochondrial injury can be caused by many different mechanisms including inhibition of mitochondrial DNA replication, transcription, translation, and altered protein function.
Michel Perron, Joy Feng
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Uniparental Genetic Heritage of Belarusians: Encounter of Rare Middle Eastern Matrilineages with a Central European Mitochondrial DNA Pool [PDF]

, 2013
Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting the Republic of Belarus. Belarusians together with Ukrainians and Russians represent the East Slavic linguistic group, largest both in numbers and territory ...
Baharak Hooshiar Kashani, Kushniarevich, Alena, Gyaneshwer Chaubey (19100), Tadeush Novogrodskii, Tsybovsky Iosif, Alena Kushniarevich, Hovhannes Sahakyan (421604), Chaubey Gyaneshwer, Davydenko O, Parik, Jüri, Reisberg, Tuuli, Kiseleva Anna, Danilenko N, Novogrodskii, Tadeush, Francesca Gandini (150515), Anna Olivieri, Rootsi, Siiri, Antonio Torroni (42164), Ene Metspalu (90748), Larysa Sivitskaya, Anna Kiseleva, Oleg Davydenko (324203), Hovhannes Sahakyan, Alena Kushniarevich (324200), Iosif Tsybovsky (250184), Metspalu Ene, Torroni, Antonio, Tuuli Reisberg (421607), Rootsi Siiri, Parik J, Hooshiar Kashani, Baharak, Siiri Rootsi (258917), Doron M. Behar (45665), Tadeush Novogrodskii (421601), Olivieri Anna, Villems, Richard, Svetlana Kotova (421603), Hooshiar Kashani Baharak, Anna Olivieri (144908), Behar Doron M., Reisberg Tuuli, Jüri Parik, Parik Jüri, Kushniarevich Alena, Doron M Behar, Oleg Davydenko, Reidla Maere, Bahmanimehr Ardeshir, Gandini Francesca, Tuuli Reisberg, Kotova Svetlana, Ene Metspalu, Richard Villems (79290), Davydenko, Oleg, Ardeshir Bahmanimehr (421605), Behar DM, Nina Danilenko, Reidla, Maere, Olivieri, Anna, Ardeshir Bahmanimehr, Achilli Alessandro, Gyaneshwer Chaubey, Davydenko Oleg, Kotova S, Villems R., Maere Reidla (273251), Bahmanimehr, Ardeshir, Torroni Antonio, Danilenko Nina, Sivitskaya L, Iosif Tsybovsky, Reisberg T, Nina Danilenko (324194), Gandini, Francesca, Anna Kiseleva (421602), Chaubey G, Jüri Parik (421606), Sivitskaya Larysa, Reidla M, Baharak Hooshiar Kashani (144912), Maere Reidla, Sahakyan H, Kotova, Svetlana, Sahakyan Hovhannes, Kiseleva, Anna, Siiri Rootsi, Tsybovsky I, Metspalu, Ene, Antonio Torroni, Villems Richard, Bahmanimehr A, Svetlana Kotova, Chaubey, Gyaneshwer, Novogrodskii T, Kushniarevich A, Metspalu E, Tsybovsky, Iosif, Danilenko, Nina, Achilli, Alessandro, Francesca Gandini, Alessandro Achilli (42157), Sahakyan, Hovhannes, Richard Villems, Larysa Sivitskaya (421600), Sivitskaya, Larysa, Kiseleva A, Alessandro Achilli, Rootsi S, Behar, Doron M., Novogrodskii Tadeush   +109 more
core   +1 more source

Structure–Function Analysis Reveals the Singularity of Plant Mitochondrial DNA Replication Components: A Mosaic and Redundant System

Plants, 2019
Plants are sessile organisms, and their DNA is particularly exposed to damaging agents. The integrity of plant mitochondrial and plastid genomes is necessary for cell survival.
Luis Gabriel Brieba
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

MITOCHONDRIAL DNA POLYMORPHISMS AND FERTILITY IN BEEF CATTLE [PDF]

, 2002
Two regions of mitochondrial DNA, D-loop and ND-5 were characterized using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) involving 422 beef cattle of Hereford and composite breeds from Wokalup’s ...
A.J, Lymbery, J.M, Cummins, ., Sutarno, RCA, Thompson   +3 more
core  

Commentary of "The Use of Mitochondrial Replacement in IVF: A Call for Expansion"

Voices in Bioethics, 2014
by Lillian Ringel • Briana’s op-ed calling for expansion of mitochondrial DNA replacement in IVF was an interesting read.  She starts her op-ed with a description of what mitochondrial DNA is, and though it may seem rudimentary to some, since I have a
Lillian Ringel, Amy Scharf
doaj   +1 more source

Complete mitochondrial genomes of two marine monogonont rotifer Brachionus manjavacas strains

Mitochondrial DNA. Part B. Resources, 2021
The complete mitochondrial genomes of Brachionus manjavacas German strain were 10,721 bp (mitochondrial DNA I) and 12,274 bp (mitochondrial DNA II) in size, while the complete mitochondrial genomes of B.
Min-Sub Kim, Young Hwan Lee, Duck-Hyun Kim, Hee-Jin Kim, Un-Ki Hwang, Russell Shiel, Atsushi Hagiwara, Jae-Seong Lee   +7 more
doaj   +1 more source

Ribonucleotides in mitochondrial DNA [PDF]

FEBS Letters, 2019
The incorporation of ribonucleotides (rNMPs) into DNA during genome replication has gained substantial attention in recent years and has been shown to be a significant source of genomic instability. Studies in yeast and mammals have shown that the two genomes, the nuclear DNA (nDNA) and the mitochondrial DNA (mtDNA), differ with regard to their rNMP ...
Wanrooij, Paulina H., Chabes, Andrei
openaire   +3 more sources