Results 51 to 60 of about 3,282,242 (309)
Mitochondrial DNA mutations in renal disease: an overview
Pediatric nephrology (Berlin, West), 2020 Kidneys have a high energy demand to facilitate the reabsorption of the glomerular filtrate. For this reason, renal cells have a high density of mitochondria. Mitochondrial cytopathies can be the result of a mutation in both mitochondrial and nuclear DNA.
Larissa P. Govers +4 more
semanticscholar +1 more source
Mitochondrial DNA in osteoarthritis disease [PDF]
Clinical Rheumatology, 2020 [Abstract] Osteoarthritis (OA) is the most prevalent chronic joint disease, and we actually know that the activation of maladaptive responses to injury, including pro-inflammatory pathways, leads to the loss of normal joint function characterized by cartilage degradation, bone remodeling, osteophyte formation, and joint inflammation [1].
Francisco J. Blanco, Ignacio Rego-Pérez
openaire +3 more sources
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Commentary of "The Use of Mitochondrial Replacement in IVF: A Call for Expansion"
Voices in Bioethics, 2014 by Lillian Ringel • Briana’s op-ed calling for expansion of mitochondrial DNA replacement in IVF was an interesting read. She starts her op-ed with a description of what mitochondrial DNA is, and though it may seem rudimentary to some, since I have a
Lillian Ringel, Amy Scharf
doaj +1 more source
Nature Immunology, 2010 Autophagy, a cellular process for organelle and protein turnover, regulates innate immune responses. Here we demonstrate that depletion of the autophagic proteins LC3B and beclin 1 enhanced the activation of caspase-1 and secretion of interleukin 1β (IL ...
K. Nakahira +12 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Plasma Mitochondrial DNA Level is a Prognostic Marker in Peritoneal Dialysis Patients
Kidney & Blood Pressure Research, 2016 Background/Aims: Circulating bacterial DNA fragment is related to systemic inflammatory state in peritoneal dialysis (PD) patients. We hypothesize that circulating mitochondrial DNA, which has a similar structure with bacterial DNA, correlates with ...
Cheuk-Chun Szeto +8 more
doaj +1 more source
BMC Psychiatry, 2023 Background Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease.
Jiewen Huang +6 more
doaj +1 more source
Mitochondrial DNA in innate immune responses and inflammatory pathology
Nature reviews. Immunology, 2017 Mitochondrial DNA (mtDNA) — which is well known for its role in oxidative phosphorylation and maternally inherited mitochondrial diseases — is increasingly recognized as an agonist of the innate immune system that influences antimicrobial responses and ...
A. West, G. Shadel
semanticscholar +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source