Results 71 to 80 of about 2,304,173 (313)

Meta-Analysis of Mitochondrial DNA Reveals Several Population Bottlenecks during Worldwide Migrations of Cattle [PDF]

, 2014
Several studies have investigated the differentiation of mitochondrial DNA in Eurasian, African and American cattle as well as archaeological bovine material.
Ginja, Catarina, David A. Magee, Ceiridwen J. Edwards, Ferretti, Luca, Beja-Pereira, Albano, Negrini, Riccardo, Marleen Felius, Juha Kantanen, Ajmone-Marsan, Paolo, Algemeen Onderzoek DGK, Lenstra, Johannes, Licia Colli, Bollongino, Ruth, Radoslavov, Georgi A., David Magee, Juan Pedro Lirón, Georgi A. Radoslavov, Ruth Bollongino, Ajmone Marsan, Paolo, Luca Ferretti, Magee, David A., Ceiridwen Edwards, Juan Lirón, Daniel G. Bradley, Riccardo Negrini, Hristov, Peter, Lenstra, Johannes A., Johannes A. Lenstra, Paolo Ajmone-Marsan, Catarina Ginja, Bradley, Daniel G., Johannes Lenstra, Albano Beja Pereira, Paolo Ajmone Marsan, Daniel Bradley, LS IRAS Tox Algemeen, Georgi Radoslavov, Peter Hristov, Beja Pereira, Albano, De Gaetano, Anna, Colli, Licia, Radoslavov, Georgi, Albano Beja-Pereira, Lirón, Juan Pedro, Anna De Gaetano, Lirón, Juan, Kantanen, Juha, Edwards, Ceiridwen J., Felius, Marleen   +48 more
core   +2 more sources

Immunological evaluation of patients with Alzheimer's disease based on mitogen-stimulated cytokine productions and mitochondrial DNA indicators

BMC Psychiatry, 2023
Background Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease.
Jiewen Huang, Zhen Song, Beiwen Wei, Qingtian Li, Ping Lin, Hui Li, Ke Dong   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors [PDF]

, 2011
Interspecies somatic cell nuclear transfer (iSCNT) involves the transfer of a nucleus or cell from one species into the cytoplasm of an enucleated oocyte from another.
St. John Justin C., Dickinson Adam, Daniel A Mitchell, Yan Jiang, Kelly Richard, Peters Amy, Fulka, Helena, Helena Fulka, Justin C. St. John, Dickinson, Adam, St. John, Justin C., Adam Dickinson, Daniel A. Mitchell, Justin C St John, Jiang Yan, Fulka Helena, Kelly, Richard D. W., Mitchell Daniel A., Mitchell, Daniel A., Peters, Amy, Richard Kelly, Jiang, Yan, Amy Peters   +22 more
core   +2 more sources

Inhibition of mTOR prevents ROS production initiated by ethidium bromide-induced mitochondrial DNA depletion.

Frontiers in Endocrinology, 2014
The regulation of mitochondrial mass and DNA content involves a complex interaction between mitochondrial DNA replication machinery, functional components of the electron transport chain, selective clearance of mitochondria, and nuclear gene expression ...
Timothy eNacarelli, Ashley eAzar, Christian eSell   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease. [PDF]

, 2013
Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of ...
Adame, Anthony, Mueller, Sarina, Bender Andreas, Sarina Mueller, Koob Andrew O., Elstner Matthias, Elstner, Matthias, Desplats, Paula, Mante, Michael, Eliezer Masliah, Desplats Paula, Mueller Sarina, Spencer, Brian, Matthias Elstner, Thomas Klopstock, Masliah, Eliezer, Koob, Andrew O., Andreas Bender, Bender, Andreas, Masliah Eliezer, Anthony Adame, Klopstock Thomas, Rockenstein, Edward, Laub Christoph, Rockenstein Edward, Pham Emily, Brian Spencer, Mante Michael, Michael Mante, Klopstock, Thomas, Christoph Laub, Spencer Brian, Adame Anthony, Andrew O Koob, Paula Desplats, Emily Pham, Laub, Christoph, Pham, Emily, Edward Rockenstein   +38 more
core   +2 more sources

SYBR Gold dye enables preferential labelling of mitochondrial nucleoids and their time-lapse imaging by structured illumination microscopy. [PDF]

PLoS ONE, 2018
Mitochondrial DNA molecules coated with proteins form compact particles called mitochondrial nucleoids. They are redistributed within mitochondrial network undergoing morphological changes. The straightforward technique to characterize nucleoids' motions
Visnja Jevtic, Petra Kindle, Sergiy V Avilov   +2 more
doaj   +1 more source

Mitochondrial DNA and ageing

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006
The accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. Although mitochondria have long been anticipated as a perpetrator of ageing, there was little experimental evidence to link these changes directly with the cellular pathology of ageing.
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source