Results 91 to 100 of about 2,304,173 (313)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Study of the Human Mitochondrial DNA Polymorphism [PDF]

, 2006
Traces of Paleolithic exodus routes of modern humans from Africa to Europe have been studied genetically using female specific ancestral lineages via mitochondrial DNA (mtDNA).
Willis, Catherine
core  

Deceleration of fusion–fission cycles improves mitochondrial quality control during aging [PDF]

, 2012
Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Michael Meyer-Hermann, Michael Meyer-Hermann (124166), Andreas S. Reichert (124162), Reichert Andreas S., Heinz D. Osiewacz (120841), Figge, Marc Thilo, Reichert, Andreas S, Marc Thilo Figge, Heinz D Osiewacz, Reichert, Andreas, Meyer-Hermann Michael, Meyer-Hermann, Michael (Prof. Dr.), Osiewacz Heinz D., Meyer-Hermann, Michael, Osiewacz, Heinz D., Andreas S Reichert, Figge Marc Thilo, Marc Thilo Figge (155511), Osiewacz, Heinz D   +18 more
core   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Inferring kangaroo phylogeny from incongruent nuclear and mitochondrial genes [PDF]

, 2013
The marsupial genus Macropus includes three subgenera, the familiar large grazing kangaroos and wallaroos of M. (Macropus) and M. (Osphranter), as well as the smaller mixed grazing/browsing wallabies of M. (Notamacropus).
Pratt, R., Michael Bunce, Pratt, Ranae C., Haouchar, D., Renae C. Pratt, Phillips, M.J., Haouchar, D, Matthew J. Phillips, Dalal Haouchar, Gillian C. Gibb (270561), Renae C Pratt, Haouchar, Dalal, Pratt, R.C., Haouchar Dalal, Gibb, G., Gibb Gillian C., Gibb, Gillian, Phillips, M., Pratt Renae C., Matthew J Phillips, Michael Bunce (31164), Gillian C. Gibb, Gibb, G.C., Gillian C Gibb, Phillips Matthew J., Matthew J. Phillips (93244), Dalal Haouchar (381128), Renae C. Pratt (381129), Bunce, M., Bunce Michael, Phillips, Matthew J., Bunce, Michael   +31 more
core   +3 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Experimental Relocation of the Mitochondrial ATP9 Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution [PDF]

, 2012
Only a few genes remain in the mitochondrial genome retained by every eukaryotic organism that carry out essential functions and are implicated in severe diseases.
Steinmetz⁎, L.M., Tetaud, Emmanuel, Steinmetz, Lars M, Annie Sainsard-Chanet, Giraud, Marie-France, Roza Kucharczyk (141980), Bietenhader, M., Raeka S Aiyar, Martos, Alexandre, Steinmetz, Lars M., Lars M Steinmetz, Sandra Clauder-Münster, Denmat, S. Hermann-Le, Dequard-Chablat, Michelle, Sylvie Hermann-Le Denmat (30181), Giraud, M.-F., Gagneur, Julien, Denmat, Sylvie Hermann-Le, Aiyar, Raeka, S, Maïlis Bietenhader, Emmanuel Tetaud (40495), Déquard-Chablat, M., Roza Kucharczyk, Martos, A., Annie Sainsard-Chanet (141993), Aiyar, R.S., Sainsard-Chanet, Annie, Isabelle Sagot, di Rago⁎, J.-P., Julien Gagneur (4350), Jean-Paul di Rago, Gagneur, J., Kucharczyk, R., Clauder-Münster, S., Jean-Paul di Rago (118317), Marie-France Giraud, Raeka S. Aiyar (141976), Godard, François, Bénédicte Salin (48466), di Rago, Jean-Paul, Carole H Sellem, Emmanuel Tetaud, Salin, Bénédicte, Godard, F., Steinmetz, Lars, M, Godard, Franc¸ois, Hermann-Le Denmat, Sylvie, Sylvie Hermann-Le Denmat, François Godard (14571), Sellem, Carole, H, Tetaud, E., Lars M. Steinmetz (36847), Véronique Contamine, Sagot, I., Alexandre Martos (141974), Contamine, V., Bénédicte Salin, Sainsard-Chanet, A., Marie-France Giraud (141983), Maïlis Bietenhader (141972), Clauder-Münster, Sandra, Sandra Clauder-Münster (141982), Isabelle Sagot (48468), François Godard, Sagot, Isabelle, Michelle Déquard-Chablat (141986), Michelle Déquard-Chablat, Julien Gagneur, Salin, B., Sellem, Carole H, Contamine, Veronique, Bietenhader, Mailis, Kucharczyk, Roza, Aiyar, Raeka S, Carole H. Sellem (141978), Véronique Contamine (141989), Alexandre Martos, Sellem, C.H.   +77 more
core   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver [PDF]

, 2005
The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period.
J A Ross, Wheelhouse, Nicholas M, D J Harrison, Wigmore, S J, Lai, P B S, P B S Lai, Wheelhouse, N M, Ross, J A, Harrison, D J, N M Wheelhouse, S J Wigmore   +10 more
core   +1 more source