Results 91 to 100 of about 614,734 (318)

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective

Cells, 2020
Mitochondria plays privotal role in diverse pathways that regulate cellular function and survival, and have emerged as a prime focus in aging and age-associated motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS) and frontotemporal ...
Manohar Kodavati, Haibo Wang, Muralidhar L. Hegde   +2 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Experimental Relocation of the Mitochondrial ATP9 Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution [PDF]

, 2012
Only a few genes remain in the mitochondrial genome retained by every eukaryotic organism that carry out essential functions and are implicated in severe diseases.
Steinmetz⁎, L.M., Tetaud, Emmanuel, Steinmetz, Lars M, Annie Sainsard-Chanet, Giraud, Marie-France, Roza Kucharczyk (141980), Bietenhader, M., Raeka S Aiyar, Martos, Alexandre, Steinmetz, Lars M., Lars M Steinmetz, Sandra Clauder-Münster, Denmat, S. Hermann-Le, Dequard-Chablat, Michelle, Sylvie Hermann-Le Denmat (30181), Giraud, M.-F., Gagneur, Julien, Denmat, Sylvie Hermann-Le, Aiyar, Raeka, S, Maïlis Bietenhader, Emmanuel Tetaud (40495), Déquard-Chablat, M., Roza Kucharczyk, Martos, A., Annie Sainsard-Chanet (141993), Aiyar, R.S., Sainsard-Chanet, Annie, Isabelle Sagot, di Rago⁎, J.-P., Julien Gagneur (4350), Jean-Paul di Rago, Gagneur, J., Kucharczyk, R., Clauder-Münster, S., Jean-Paul di Rago (118317), Marie-France Giraud, Raeka S. Aiyar (141976), Godard, François, Bénédicte Salin (48466), di Rago, Jean-Paul, Carole H Sellem, Emmanuel Tetaud, Salin, Bénédicte, Godard, F., Steinmetz, Lars, M, Godard, Franc¸ois, Hermann-Le Denmat, Sylvie, Sylvie Hermann-Le Denmat, François Godard (14571), Sellem, Carole, H, Tetaud, E., Lars M. Steinmetz (36847), Véronique Contamine, Sagot, I., Alexandre Martos (141974), Contamine, V., Bénédicte Salin, Sainsard-Chanet, A., Marie-France Giraud (141983), Maïlis Bietenhader (141972), Clauder-Münster, Sandra, Sandra Clauder-Münster (141982), Isabelle Sagot (48468), François Godard, Sagot, Isabelle, Michelle Déquard-Chablat (141986), Michelle Déquard-Chablat, Julien Gagneur, Salin, B., Sellem, Carole H, Contamine, Veronique, Bietenhader, Mailis, Kucharczyk, Roza, Aiyar, Raeka S, Carole H. Sellem (141978), Véronique Contamine (141989), Alexandre Martos, Sellem, C.H.   +77 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Analysis of mitochondrial DNA variation in the Egyptian population and its implications for forensic DNA analysis

, 2010
The genetic sequence of human mitochondrial DNA (mtDNA) is of particular interest to forensic investigations involving human identification, as well as population genetics.
Gomaa, R
core  

Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair. [PDF]

Theranostics, 2022
Kim HJ, Cho HB, Lee S, Lyu J, Kim HR, Lee S, Park JI, Park KH.   +7 more
europepmc   +1 more source

Mitochondrial DNA mitochondrial dysfunction and cardiac manifestations

Frontiers in Bioscience, 2016
Mitochondria, the powerhouses of cells, have their own DNA (mtDNA). They regulate the transport of metabolites and ions, which determine cell physiology, survival, and death. Mitochondrial dysfunction, including impaired oxidative phosphorylation, preferentially affects heart function via imbalance of energy supply and demand.
Sung Ryul, Lee, Nari, Kim, Yeun Hee, Noh, Zhelong, Xu, Kyung Soo, Ko, Byoung Doo, Rhee, Jin, Han   +6 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The N-terminal intrinsically disordered domain of mgm101p is localized to the mitochondrial nucleoid.

, 2013
The mitochondrial genome maintenance gene, MGM101, is essential for yeasts that depend on mitochondrial DNA replication. Previously, in Saccharomyces cerevisiae, it has been found that the carboxy-terminal two-thirds of Mgm101p has a functional core ...
George Desmond Clark-Walker (281878), George Desmond Clark-Walker, Dosztányi Zsuzsanna, Zsuzsanna Dosztányi (57464), Clark-Walker, George Desmond, Zsuzsanna Dosztányi, Clark-Walker George Desmond, David C. Hayward (198611), David C. Hayward, Hayward David C., Hayward, David C., Dosztányi, Zsuzsanna, David C Hayward   +12 more
core   +1 more source