Results 111 to 120 of about 614,734 (318)

Mitochondrial DNA and Genetic Disease [PDF]

Developmental Medicine & Child Neurology, 1988
AbstractSince the human mitochondrial genome was characterised and sequenced in 1981(1), it has been viewed as the likely site of genetic diseases showing a maternal inheritance pattern and associated with defects of the respiratory chain, such as the mitochondrial myopathies (MMs)†(2).
openaire   +4 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Complete mitochondrial DNA genome of Triplophysa venusta (Cypriniformes: Cobitida)

, 2016
The complete mitochondrial DNA sequence of Triplophysa venusta was determined using a PCR-based method in our present study. The genome is totally 16 574 bp in length and contains 13 protein-coding genes, 2 ribosomal RNA, 22 transfer RNA genes, and 1 non-
Liang, Yin-Quan, Li, Ming, Zhang, Yu, Wang, Chong, Shen, Zai-Jun, Jiang, Zhi-Wu   +5 more
core   +1 more source

The Multifaceted Origin of Taurine Cattle Reflected by the Mitochondrial Genome [PDF]

, 2009
A Neolithic domestication of taurine cattle in the Fertile Crescent from local aurochsen (Bos primigenius) is generally accepted, but a genetic contribution from European aurochsen has been proposed.
Malusà, Arianna, Perego, Ugo A., Baharak Hooshiar Kashani, Baharak Hooshiar, Bandelt, Hans-Jürgen, Ferretti, Luca, Pala, Maria, Paolo Ajmone-Marsan, Silvia Bonfiglio, BANDELT HJ, Ugo A Perego, PEREGO, UGO ALESSANDRO, Hans-Jürgen Bandelt, Antonio Torroni, Ornella Semino, Ajmone-Marsan, Paolo, Ro Achilli, Achilli, Alessandro, Liotta, Luigi, Semino, Ornella, Anna Olivieri, LIOTTA L, Ajmone Marsan, Paolo, AJMONE MARSAN P, Luca Ferretti, Luigi Liotta, Torroni, Antonio, Maria Pala, Ugo A. Perego, Alessandro Achilli, Olivieri, Anna, Bonfiglio, Silvia, Arianna Malusà, Hooshiar Kashani, Baharak, MALUSA', ARIANNA   +34 more
core   +1 more source

Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease

Neurobiology of Disease, 2016
Mitochondrial DNA regulates mitochondrial function which is altered in both idiopathic and familial forms of Parkinson's disease. To investigate whether these two disease forms exhibit an altered regulation of mitochondrial DNA we measured cell free ...
Petar Podlesniy, Dolores Vilas, Peggy Taylor, Leslie M. Shaw, Eduard Tolosa, Ramon Trullas   +5 more
doaj   +1 more source

Mitochondrial DNA-related Disorders

Bioscience Reports, 2007
Mitochondrial diseases are a group of disorders due to a mitochondrial respiratory chain deficiency. They may depend on mitochondrial genome (mtDNA-related disorders) as well as on a nuclear genome defect (nDNA-related disorders). mtDNA-related disorders encompass an increasing number of clinical pictures associated with more than 250 different ...
MANCUSO, MICHELANGELO, FILOSTO M, CHOUB A, TENTORIO M, BROGLIO L, PADOVANI A, SICILIANO, GABRIELE   +6 more
openaire   +4 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A study of mitochondrial biogenesis in the rodent nervous system

, 2015
This thesis investigates the process of mitochondrial biogenesis in the rodent CNS in the context of neuroinflammatory and neurodegenerative disease. There is mounting evidence of mitochondrial damage in neuroinflammation but very little is known about ...
Desai, R
core  

Phylogenetic study of Ameiurus melas based on complete mitochondrial DNA sequence

, 2016
In our research, 16 sets of primers were used to amplify contiguous, overlapping segments of the complete mitochondrial DNA (mtDNA) of Ameiurus melas. The total length of the mitochondrial genome is 16 512 bp and deposited in the GenBank with accession ...
Yu, Juhua, Fang, Yanhong, Zhou, Yi, Wang, Wenjun, Yang, Zhong, Yan, Jinpeng, Yu, Fan   +6 more
core   +1 more source

Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases

Genes and Diseases
Neuronal death is associated with mitochondrial dysfunction caused by mutations in mitochondrial DNA. Mitochondrial DNA becomes damaged when processes such as replication, repair, and nucleotide synthesis are compromised.
Ye Hong, Ying Song, Wenjun Wang, Jinghui Shi, Xi Chen   +4 more
doaj   +1 more source