Results 111 to 120 of about 3,282,242 (309)
Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases
Genes and DiseasesNeuronal death is associated with mitochondrial dysfunction caused by mutations in mitochondrial DNA. Mitochondrial DNA becomes damaged when processes such as replication, repair, and nucleotide synthesis are compromised.
Ye Hong +4 more
doaj +1 more source
Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
FEBS Letters, 2018 Mitochondria are essential organelles within the cell where most ATP is produced through oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are encoded by the mitochondrial DNA (mtDNA).
N. Nissanka, Carlos T. Moraes
semanticscholar +1 more source
Rapid isolation of mitochondrial DNA. Mitochondrial DNA fromDrosophila serrata
Experientia, 1992 Uploaded by Plazi for TaxoDros. We do not have abstracts.
P, Pissios, Z G, Scouras
openaire +2 more sources
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Tumor Biology, 2017 Head and neck squamous cell carcinoma is the most commonly diagnosed cancer worldwide. The lifestyle, food habits, and customary practices manifest the Northeast Indian population toward higher susceptibility to develop head and neck squamous cell ...
Manish Kumar +7 more
doaj +1 more source
Mitochondrial DNA-related Disorders
Bioscience Reports, 2007 Mitochondrial diseases are a group of disorders due to a mitochondrial respiratory chain deficiency. They may depend on mitochondrial genome (mtDNA-related disorders) as well as on a nuclear genome defect (nDNA-related disorders). mtDNA-related disorders encompass an increasing number of clinical pictures associated with more than 250 different ...
MANCUSO, MICHELANGELO +6 more
openaire +4 more sources
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance
Nature, 2021 M. Tigano +4 more
semanticscholar +1 more source
Mitochondrial DNA Mutations in Cardiomyopathy.
Japanese Circulation Journal, 1992 Deletions and point mutations of mitochondrial DNA (mtDNA) of patients with dilated or hypertrophic cardiomyopathy were analyzed using the polymerase chain reaction and fluorescence-based direct sequencing. The patients included are with hypertrophic cardiomyopathy associated with left ventricular dilatation, a patient with mitochondrial myopathy ...
ITO, TAKAYUKI +5 more
openaire +3 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source