Results 111 to 120 of about 2,421,986 (315)

Recombinant Mitochondrial Transcription Factor A with N-terminal Mitochondrial Transduction Domain Increases Respiration and Mitochondrial Gene Expression in G11778A Leber's Hereditary Optic Neuropathy Cybrid Cells [PDF]

, 2008
Diseases involving mitochondrial defects usually manifest themselves in high-energy, post-mitotic tissues such as brain, retina, skeletal and cardiac muscle and frequently cause deficiencies in mitochondrial bioenergetics.
James P. Bennett, Ravindar R. Thomas, Shilpa Iyer, Francisco R. Portell, Caitlin K. Quigley, Lisa D. Dunahm   +5 more
core  

Nucleic acids and protein synthesis in cancer cell mitochondria. I. Nucleic acids in rat hepatoma mitochondria [PDF]

, 1967
The contents of nucleic acids in rat liver and hepatoma mitochondria and the physico-chemical properties on DNA's isolated from these mitochondria were comparatively investigated. The results are briefly summarized as follows. 1.
Inaba, Kozo
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Rapid isolation of mitochondrial DNA. Mitochondrial DNA fromDrosophila serrata

Experientia, 1992
Uploaded by Plazi for TaxoDros. We do not have abstracts.
P, Pissios, Z G, Scouras
openaire   +2 more sources

The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia [PDF]

, 2010
Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo ...
Perego, Ugo A., Baharak Hooshiar Kashani, Woodward, Scott R., Zimmermann B, Daniel Corach, Lancioni, Hovirag, Panara, Fausto, Huber G, Nora Babudri, Gabriela Huber, Kashani, Baharak Hooshiar, Babudri N, Valeria Carossa, Woodward SR, Anna Olivieri, Natalie M. Myres, Huber, Gabriela, Ekins JE, Jayne E. Ekins, Torroni, Antonio, Ugo A. Perego, Norman Angerhofer, Hooshiar Kashani, Baharak, Panara F, Scott R. Woodward, Parson W, Carossa, Valeria, Walther Parson, Gómez Carballa, Alberto, Pala, Maria, Babudri, Nora, Parson, Walther, Lancioni H, Myres NM, PEREGO, UGO ALESSANDRO, Alberto Gómez-Carballa, Antonio Torroni, Corach D, Zimmermann, Bettina, Ornella Semino, Salas A, Antonio Salas, Hovirag Lancioni, Angerhofer N, Gomez-Carballa, Alberto, Angerhofer, Norman, Achilli, Alessandro, Semino, Ornella, Salas, Antonio, Gómez Carballa A, Myres, Natalie M., Ekins, Jayne E., Corach, Daniel, Maria Pala, Alessandro Achilli, Bettina Zimmermann, Olivieri, Anna, Fausto Panara   +57 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Mitochondrial DNA-related Disorders

Bioscience Reports, 2007
Mitochondrial diseases are a group of disorders due to a mitochondrial respiratory chain deficiency. They may depend on mitochondrial genome (mtDNA-related disorders) as well as on a nuclear genome defect (nDNA-related disorders). mtDNA-related disorders encompass an increasing number of clinical pictures associated with more than 250 different ...
MANCUSO, MICHELANGELO, FILOSTO M, CHOUB A, TENTORIO M, BROGLIO L, PADOVANI A, SICILIANO, GABRIELE   +6 more
openaire   +4 more sources

Mitochondrial DNA reveals genetic structuring of Pinna nobilis across the Mediterranean Sea [PDF]

, 2013
Pinna nobilis is the largest endemic Mediterranean marine bivalve. During past centuries, various human activities have promoted the regression of its populations.
Sanna Daria, Curini Galletti M, Marco Casu (428260), Casu M., Piero Cossu (428254), Fabio Scarpa, Paolo Francalacci (32750), Sanna D., Maltagliati, Ferruccio, Cossu, Piero, Daria Sanna, Dedola Gian Luca, Ferruccio Maltagliati (389017), Gian Luca Dedola, Sanna, Daria, Marco Curini-Galletti (175692), Lai T., Piero Franzoi, Maltagliati Ferruccio, Alberto Castelli, Lai Tiziana, Curini-Galletti Marco, Marco Casu, Daria Sanna (428253), Cristo Benedetto, Casu, Marco, Ferruccio Maltagliati, Curini Galletti, Marco, Francalacci P, Castelli A, Sanna D, Castelli A., Piero Franzoi (428257), Maltagliati F., Francalacci, Paolo, Scarpa, Fabio, Scarpa Fabio, Benedetto Cristo (428259), Dedola G. L., Franzoi P., Cossu P, Castelli, Alberto, Paolo Francalacci, Franzoi P, Cristo, Benedetto, Scarpa F., Cossu Piero, Marco Curini-Galletti, Curini Galletti M., Cossu P., Tiziana Lai, Fabio Scarpa (428256), Maltagliati F, Piero Cossu, Gian Luca Dedola (428255), Franzoi Piero, Franzoi, Piero, Lai, Tiziana, Casu Marco, Cristo B., Castelli Alberto, Dedola G.L., Benedetto Cristo, Tiziana Lai (428258), Dedola, Gian Luca, Scarpa F, Francalacci P., Lai T, Francalacci Paolo, Curini-Galletti M., Cristo B, Alberto Castelli (241292), Dedola GL   +72 more
core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases

Genes and Diseases
Neuronal death is associated with mitochondrial dysfunction caused by mutations in mitochondrial DNA. Mitochondrial DNA becomes damaged when processes such as replication, repair, and nucleotide synthesis are compromised.
Ye Hong, Ying Song, Wenjun Wang, Jinghui Shi, Xi Chen   +4 more
doaj   +1 more source