Results 291 to 300 of about 299,286 (332)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Whole-genome landscapes of 1,364 breast cancers. [PDF]

Nature
Kim R, Yu J, Lim J, Oh BB, Nam SJ, Kim SW, Lee JE, Chae BJ, Kim JY, Park GE, Kang BJ, Paik PS, Bae SY, Yoon CI, Lee YJ, Kim D, Shin K, Lee JE, Kang J, Lee A, Connolly-Strong E, Lee S, Lee BR, Lee Y, Yi KJ, Kwon YO, Chun IH, Park J, Kim J, Choi C, Shin JY, Lee H, Kim M, Park H, Jeong I, Yi B, Lee WC, Lee JS, Park WC, Kim SH, Choi YL, Lee J, Ju YS, Park YH.   +43 more
europepmc   +1 more source

CRISPR/Cas9‐Assisted Microrobots for Fast and Ultrasensitive “On‐The‐Fly” Next‐Generation DNA Detection

Advanced Functional Materials, EarlyView.
This work presents self‐propelled CRISPR/Cas9‐functionalized Au–MRs for rapid, amplification‐free, “on‐the‐fly” DNA detection. By harnessing motion‐assisted signal recovery, the platform achieved the limit of detection in low fM DNA concentrations, enabling detection across a wide dynamic range within only 5 min, which is significantly faster than any ...
Jyoti, Petr Michálek, Zbyněk Heger, Martin Pumera   +3 more
wiley   +1 more source

Determinants of sensitivity to HER2-targeted antibody drug conjugates in urothelial cancer. [PDF]

Nat Commun
Chen Z, Tang X, Eichholz JE, Mcpherson A, Thomas J, Nagar K, Rustgi N, Christin JR, Kuo F, Gao S, Jiang H, Luo J, Ostrovnaya I, Basar M, Pietzak E, Coleman JA, Berger MF, de Stanchina E, Shah SP, Mohibullah N, Aggen DH, Rosenberg JE, Chandarlapaty S, Shen MM, Al-Ahmadie H, Iyer G, Kim K, Solit DB.   +27 more
europepmc   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin. [PDF]

Science
Carlson ES, Haslecker R, Lecchi C, Aguilar Ramos MA, Vennelakanti V, Honaker L, Stornetta A, Millán ES, Johnson BA, Kulik HJ, Balbo S, Villalta PW, D'Souza VM, Balskus EP.   +13 more
europepmc   +1 more source

Integrative Approaches for DNA Sequence‐Controlled Functional Materials

Advanced Functional Materials, EarlyView.
DNA is emerging as a programmable building block for functional materials with applications in biomimicry, biochemical, and mechanical information processing. The integration of simulations, experiments, and machine learning is explored as a means to bridge DNA sequences with macroscopic material properties, highlighting current advances and providing ...
Aaron Gadzekpo, Ewa Anna Oprzeska‐Zingrebe, Mariana Kozlowska, Lennart Hilbert, Iliya D. Stoev   +4 more
wiley   +1 more source

Comprehensive Mutational Landscape of Yeast Mutator Strains Reveals the Genetic Basis of Mutational Signatures in Cancer. [PDF]

Mol Biol Evol
Liu L, Sun D, Liu H.
europepmc   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Molecular Landscape of Advanced Endometrial Cancer: Exploratory Analyses at Modena Cancer Center (MEMO). [PDF]

Int J Mol Sci
Pirola M, Molinaro E, Manfredini S, Cuoghi Costantini R, Carlucci C, Piombino C, Pipitone S, Vitale MG, Sabbatini R, Bacchelli F, Botticelli L, Eccher A, D'Amico R, Longo L, Bettelli S, Baldessari C, Dominici M.   +16 more
europepmc   +1 more source