Results 101 to 110 of about 945,929 (245)

Unique Inhibitory Effect of 1-(2′-Deoxy-2′-fluoro-β-l-arabinofuranosyl)-5-methyluracil 5′-Triphosphate on Epstein-Barr Virus and Human DNA Polymerases

, 1998
Marina K. Kukhanova, Zhen‐Yuan Lin, Maxim Yas’co, Yung‐Chi Cheng   +3 more
openalex   +1 more source

DNA sequence variation within maize and melon: observations from polymerase chain reaction amplification and direct sequencing. [PDF]

, 1990
Donna Shattuck-Eidens, Russel Bell, Susan L. Neuhausen, T. Helentjaris   +3 more
openalex   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

DNA polymerase swapping in Caudoviricetes bacteriophages

Virology Journal
Background Viruses with double-stranded (ds) DNA genomes in the realm Duplodnaviria share a conserved structural gene module but show a broad range of variation in their repertoires of DNA replication proteins. Some of the duplodnaviruses encode (nearly)
Natalya Yutin, Igor Tolstoy, Pascal Mutz, Yuri I. Wolf, Mart Krupovic, Eugene V. Koonin   +5 more
doaj   +1 more source

PCNA Mono-Ubiquitination and Activation of Translesion DNA Polymerases by DNA Polymerase   [PDF]

, 2010
Masatoshi Suzuki, A Niimi, Siripan Limsirichaikul, Shuta Tomida, Qingjun Huang, S. Izuta, Jiro Usukura, Yasutomo Itoh, Takashi Hishida, Tomohiro Akashi, Yosuke Nakagawa, Akihiko Kikuchi, Youri I. Pavlov, Takashi Murate, Takashi Takahashi   +14 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Target liquid biopsy using “enriched” polymerase chain reaction and DNA melting analysis

, 2018
I. V. Botezatu, Irina Panchuk, A. А. Kolomeytseva, А. А. Феденко, Н. Н. Мазуренко, I. V. Tsyganova, Olga Yu. Susova, В. Н. Кондратова, В. П. Шелепов, A. V. Lichtenstein   +9 more
openalex   +2 more sources

Identification of a Fourth Subunit of Mammalian DNA Polymerase δ [PDF]

, 2000
Li Liu, Jinyao Mo, Esther Rodríguez‐Belmonte, Marietta Lee   +3 more
openalex   +1 more source