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Electrostatics of Polymorphic DNA
Journal of Biomolecular Structure and Dynamics, 1983The molecular electrostatic potential (MEP) and the molecular electrostatic field (MEF) are associated with significantly different patterns of distribution in the nucleic acids and their constituents. In particular, a) while the values of the minimal potentials at the reactive sites of the bases or at the phosphates increase manyfold when going from ...
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Mitochondrial DNA polymorphisms and extraversion
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004AbstractMitochondria is the major site of energy production in cells, therefore, mitochondrial abnormality may affect functions of organs including the brain, which constantly requires high levels of energy consumption. Previous studies have suggested a role of mitochondria and their DNA polymorphisms in neuro‐psychiatric disorders, including Alzheimer'
Chieko, Kato +8 more
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DNA Polymorphism and Human Disease
Annual Review of Biochemistry, 1986PERSPECTIVES AND SUMMARY 831 RESTRICTION FRAGMENT LENGTH POLyMORPHISM 832 Definition and Detection 832 Gene Probes . . ..... . , , , 834 Anonymous DNA Probes 834 Repetitive Probes 838 LOCALIZATION OF HUMAN DISEASE GENES .. ..... .. 839 Disease Categories 839 RFLPs as Genetic Markers 841 Linkage Analysis for Mapping Disease Loci 843 ...
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DNA polymorphisms within SpanishTrichinella isolates
Parasitology Research, 1991A total of 13 Spanish Trichinella isolates were characterised by DNA analysis. Genomic DNA cross-hybridisation tests revealed two distinct groups that exhibited weak cross-reactions. Further diagnostic subdivision was attempted according to restriction-fragment polymorphism using a cloned T.
T, Garate +4 more
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Rinsho byori. The Japanese journal of clinical pathology, 2014
Genetic variations, including single nucleotide polymorphisms (SNP), variable numbers of repetitive sequences such as microsatellite polymorphisms, and small insertion-deletion polymorphisms (INDELs), have been reportedly associated with various diseases.
Yutaka, Suehiro +3 more
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Genetic variations, including single nucleotide polymorphisms (SNP), variable numbers of repetitive sequences such as microsatellite polymorphisms, and small insertion-deletion polymorphisms (INDELs), have been reportedly associated with various diseases.
Yutaka, Suehiro +3 more
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New Application for DNA Polymorphism
New England Journal of Medicine, 1987The paper by Fearon and coworkers in this issue illustrates the expanding and exciting role of DNA technology in clinical medicine.1 First applied less than a decade ago, this technology has already contributed to our understanding of the basic mechanisms of disease, provided new means of diagnosis, and made available new therapeutic methods.
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DNA polymorphism and clinical genetics
The Indian Journal of Pediatrics, 1986Introduction of recombinant DNA technology in clinical genetics has provided a more deeper understanding of the molecular basis of inherited disorders in man. Application of these techniques led to detection as well as prevention of genetic defects in risk-prone families. This paper provides a brief outline of the methods involved in prenatal diagnosis
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Mitochondrial DNA polymorphisms in bipolar disorder
Journal of Affective Disorders, 2001Previous studies suggested mitochondrial abnormality in bipolar disorder: (1) possible contribution of parent-of-origin effect in transmission of bipolar disorder; (2) abnormal brain phosphorus metabolism detected by phosphorus-31 magnetic resonance spectroscopy; (3) comorbidity of affective disorders in patients with mitochondrial encephalopathy; (4 ...
T, Kato, H, Kunugi, S, Nanko, N, Kato
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Dna amplification polymorphisms of Mucor piriformis
Antonie van Leeuwenhoek, 1997Mucor piriformis can cause postharvest decay in various fruits and vegetables stored at low temperatures. Thirty isolates of this fungus, collected from infected fruit, were subjected to random amplified polymorphic DNA (RAPD) analysis. Seven different 10-bp primers were used to determine the type and extent of intraspecific genetic polymorphisms ...
T, Papp +4 more
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Structural polymorphism of DNA-dendrimer complexes
Physical Review Letters, 2003DNA condensation in vivo relies on electrostatic complexation with small cations or large histones. We report a synchrotron x-ray study of the phase behavior of DNA complexed with synthetic cationic dendrimers of intermediate size and charge. We encounter unexpected structural transitions between columnar mesophases with in-plane square and hexagonal ...
Evans, H. M. +6 more
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