Results 101 to 110 of about 3,927,360 (403)

Understanding Enhanced Mechanical Stability of DNA in the Presence of Intercalated Anticancer Drug: Implications for DNA Associated Processes [PDF]

J. Chem. Phys. 151, 164902 (2019), 2019
Most of the anticancer drugs bind to double-stranded DNA (dsDNA) by intercalative-binding mode. Although experimental studies have become available recently, a molecular-level understanding of the interactions between the drug and dsDNA that lead to the stability of the intercalated drug is lacking.
arxiv   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Microarray-based ultra-high resolution discovery of genomic deletion mutations [PDF]

, 2014
BACKGROUND: Oligonucleotide microarray-based comparative genomic hybridization (CGH) offers an attractive possible route for the rapid and cost-effective genome-wide discovery of deletion mutations.
Baban, D., Belfield, E., Brown, C., Gan, X., Harberd, N., Jiang, C., Mithani, A., Mott, R., Ragoussis, J.   +8 more
core   +5 more sources

Shining a Spotlight on DNA: Single-Molecule Methods to Visualise DNA

Molecules, 2019
The ability to watch single molecules of DNA has revolutionised how we study biological transactions concerning nucleic acids. Many strategies have been developed to manipulate DNA molecules to investigate mechanical properties, dynamics and protein ...
Gurleen Kaur, Jacob S. Lewis, Antoine M. van Oijen   +2 more
doaj   +1 more source

Sensing DNA - DNA as nanosensor: a perspective towards nanobiotechnology [PDF]

arXiv, 2005
Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA may be used as a local sensor.
arxiv  

Length scale dependence of DNA mechanical properties [PDF]

, 2012
Although mechanical properties of DNA are well characterized at the kilo base-pair range, a number of recent experiments have suggested that DNA is more flexible at shorter length scales, which correspond to the regime that is crucial for cellular processes such as DNA packaging and gene regulation.
arxiv   +1 more source

Sequence Heterogeneity Accelerates Protein Search for Targets on DNA [PDF]

, 2015
The process of protein search for specific binding sites on DNA is fundamentally important since it marks the beginning of all major biological processes. We present a theoretical investigation that probes the role of DNA sequence symmetry, heterogeneity
Alberts B., Alexey A. Shvets, Anatoly B. Kolomeisky, Dill K. A., Lodish H., Phillips R.   +5 more
core   +2 more sources

Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

Genome Biology, 2016
In recent years the Illumina HumanMethylation450 (HM450) BeadChip has provided a user-friendly platform to profile DNA methylation in human samples. However, HM450 lacked coverage of distal regulatory elements.
R. Pidsley, E. Zotenko, Timothy J. Peters, M. Lawrence, G. Risbridger, P. Molloy, Susan Van Djik, B. Muhlhausler, C. Stirzaker, S. Clark   +9 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A Careful Insight into DDI-Type Receptor Layers on the Way to Improvement of Click-Biology-Based Immunosensors

Biosensors
Protein-based microarrays are important tools for high-throughput medical diagnostics, offering versatile platforms for multiplex immunodetection. However, challenges arise in protein microarrays due to the heterogeneous nature of proteins and, thus ...
Sylwia Karoń, Marcin Drozd, Elżbieta Malinowska   +2 more
doaj   +1 more source