Results 151 to 160 of about 792,120 (349)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Programming Fluorogenic DNA Probes for Rapid Detection of Steroids. [PDF]

Angew Chem Int Ed Engl, 2021
Ebrahimi SB, Samanta D, Partridge BE, Kusmierz CD, Cheng HF, Grigorescu AA, Chávez JL, Mirau PA, Mirkin CA.   +8 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A denaturation-free protocol for in situ visualization of short nuclear DNA sequences using padlock probes with rolling-circle amplification.

PLoS ONE
We report an approach for in situ detection of genomic DNA sequences, where transiently opening DNA duplexes are captured by circularizing DNA strands - padlock probes - that lock in place in a sequence-specific manner through the action of a DNA ligase.
Ryoyo Ikebuchi, Lu Xi, Dimitra Bouri, Valeriia Svintytska, Hanna Davies, Pawel Olszewski, Bozena Bruhn-Olszewska, Jan P Dumanski, Ulf Landegren   +8 more
doaj   +1 more source

Fluorescent aptasensor for detection of live foodborne pathogens based on multicolor perovskite-quantum-dot-encoded DNA probes and dual-stirring-bar-assisted signal amplification. [PDF]

J Pharm Anal, 2022
Liu L, Hong J, Wang W, Xiao S, Xie H, Wang Q, Gan N.   +6 more
europepmc   +1 more source

Probing DNA Topology Using Tethered Particle Motion

, 2011
David Dunlap, Chiara Zurla, Carlo Manzo, Laura Finzi   +3 more
openalex   +2 more sources

Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe [PDF]

, 2018
Suge Zhang, Hongxia Sun, Lixia Wang, Yan Liu, Hongbo Chen, Qian Li, Aijiao Guan, Meirong Liu, Yalin Tang   +8 more
openalex   +1 more source

DNA Probes [PDF]

, 2020
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning. [PDF]

Biosens Bioelectron, 2022
Moitra P, Chaichi A, Abid Hasan SM, Dighe K, Alafeef M, Prasad A, Gartia MR, Pan D.   +7 more
europepmc   +1 more source